Industry 4.0 seeks to combine the real and cyber worlds by implementing cyber-physical systems (CPS) within industrial processes to create a self-managing network between humans, machines, products, and other related objects. An important part of the current transformation to Industry 4.0 is the emphasis on human-centricity, allowing for a paradigm shift from independent automated and human activities towards a human-automation symbiosis. This symbiosis is characterized by the cooperation between machines and humans in work systems and is designed not to replace the skills and abilities of humans, but rather to co-exist and assist humans in being more efficient and effective. The paper presents a systematic literature review (SLR) to identify principles for the human-centered design of future CPS. The SLR follows widely accepted methodologies and introduces concepts and visions for the elicitation of operators’ roles and needs in Industry 4.0.