Primaquine-based ionic liquids as a novel class of antimalarial hits

Ricardo Ferraz, Joana Noronha, Fernanda Murtinheira, Fátima Nogueira, Marta Machado, Miguel Prudêncio, Silvia Parapini, Sarah D'Alessandro, Cátia Teixeira, Ana Gomes, Cristina Prudêncio, Paula Gomes

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Ionic liquids derived from active pharmaceutical ingredients may open new perspectives towards low-cost rescuing of classical drugs. Thus, we have synthesized novel ionic liquids derived from the antimalarial drug primaquine, and evaluated them in vitro against three stages of malaria parasites. Results from this unprecedented approach open a new chapter in the history of antimalarial drugs.

Original languageEnglish
Pages (from-to)56134-56138
Number of pages5
JournalRCS Advances
Volume6
Issue number61
DOIs
Publication statusPublished - 2016

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    Ferraz, R., Noronha, J., Murtinheira, F., Nogueira, F., Machado, M., Prudêncio, M., ... Gomes, P. (2016). Primaquine-based ionic liquids as a novel class of antimalarial hits. RCS Advances, 6(61), 56134-56138. https://doi.org/10.1039/c6ra10759a