Primaquine-based ionic liquids as a novel class of antimalarial hits

Ricardo Ferraz; Joana Noronha; Fernanda  Murtinheira; Fátima Nogueira; Marta Machado; Miguel Prudêncio; Silvia Parapini; Sarah D'Alessandro; Cátia Teixeira; Ana Gomes; Cristina Prudêncio; Paula Gomes

doi:10.1039/c6ra10759a

Primaquine-based ionic liquids as a novel class of antimalarial hits

Ricardo Ferraz, Joana Noronha, Fernanda Murtinheira, Fátima Nogueira, Marta Machado, Miguel Prudêncio, Silvia Parapini, Sarah D'Alessandro, Cátia Teixeira, Ana Gomes, Cristina Prudêncio, Paula Gomes

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Ionic liquids derived from active pharmaceutical ingredients may open new perspectives towards low-cost rescuing of classical drugs. Thus, we have synthesized novel ionic liquids derived from the antimalarial drug primaquine, and evaluated them in vitro against three stages of malaria parasites. Results from this unprecedented approach open a new chapter in the history of antimalarial drugs.

Original language	English
Pages (from-to)	56134-56138
Number of pages	5
Journal	RSC Advances
Volume	6
Issue number	61
DOIs	https://doi.org/10.1039/c6ra10759a
Publication status	Published - 2016

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abstract = "Ionic liquids derived from active pharmaceutical ingredients may open new perspectives towards low-cost rescuing of classical drugs. Thus, we have synthesized novel ionic liquids derived from the antimalarial drug primaquine, and evaluated them in vitro against three stages of malaria parasites. Results from this unprecedented approach open a new chapter in the history of antimalarial drugs.",

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AU - Ferraz, Ricardo

AU - Noronha, Joana

AU - Murtinheira, Fernanda

AU - Nogueira, Fátima

AU - Machado, Marta

AU - Prudêncio, Miguel

AU - Parapini, Silvia

AU - D'Alessandro, Sarah

AU - Teixeira, Cátia

AU - Gomes, Ana

AU - Prudêncio, Cristina

AU - Gomes, Paula

PY - 2016

Y1 - 2016

N2 - Ionic liquids derived from active pharmaceutical ingredients may open new perspectives towards low-cost rescuing of classical drugs. Thus, we have synthesized novel ionic liquids derived from the antimalarial drug primaquine, and evaluated them in vitro against three stages of malaria parasites. Results from this unprecedented approach open a new chapter in the history of antimalarial drugs.

AB - Ionic liquids derived from active pharmaceutical ingredients may open new perspectives towards low-cost rescuing of classical drugs. Thus, we have synthesized novel ionic liquids derived from the antimalarial drug primaquine, and evaluated them in vitro against three stages of malaria parasites. Results from this unprecedented approach open a new chapter in the history of antimalarial drugs.

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DO - 10.1039/c6ra10759a

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EP - 56138

JO - RSC Advances

JF - RSC Advances

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ER -

Primaquine-based ionic liquids as a novel class of antimalarial hits

Abstract

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