Abstract
We describe the case of a patient with Cushing's syndrome due to a functioning adrenal adenoma. There was a pronounced increase in serum and urinary cortisol after administration of human chorionic gonadotropin. Immunocytochemistry revealed positive immunostaining for LH/hCG receptors. Molecular analysis documented the presence of a gsp mutation at codon 201 (CGT to TGT). The existence of this type of hCG-responsive adrenal tumor may help explain the higher prevalence of cortisol-secreting adrenal tumors versus pituitary-dependent disease in pregnant women with Cushing's syndrome as well as some reported cases of remission following delivery.
Original language | English |
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Pages (from-to) | 50-54 |
Number of pages | 5 |
Journal | Gynecological Endocrinology |
Volume | 14 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2000 |
Keywords
- Cushing's syndrome
- gsp mutations
- LH/hCG receptors