Preprocessing and Analyzing Genetic Data with Complex Networks: an Application to Obstructive Nephropathy

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Abstract

Many diseases have a genetic origin, and a great effort is being made to detect the genes that are responsible for their insurgence. One of the most promising techniques is the analysis of genetic information through the use of complex networks theory. Yet, a practical problem of this approach is its computational cost, which scales as the square of the number of features included in the initial dataset. In this paper, we propose the use of an iterative feature selection strategy to identify reduced subsets of relevant features, and show an application to the analysis of congenital Obstructive Nephropathy. Results demonstrate that, besides achieving a drastic reduction of the compu- tational cost, the topologies of the obtained networks still hold all the relevant information, and are thus able to fully characterize the severity of the disease.
Original languageUnknown
Pages (from-to)473-481
JournalNetworks And Heterogeneous Media
Volume7
Issue numberSI3
DOIs
Publication statusPublished - 1 Jan 2012

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