TY - JOUR
T1 - Preparation of ethyl cellulose/methyl cellulose blends by supercritical antisolvent precipitation
AU - Duarte, Ana Rita C.
AU - Gordillo, M. D.
AU - Cardoso, M. Margarida
AU - Simplício, Ana Luísa
AU - Duarte, Catarina M.M.
N1 - Funding Information:
This work was financially supported by FCT-MCES and FEDER, Portugal, under contract POCTI/EQU/46715/2002. Ana Rita C. Duarte is grateful for the SFRH/BD/10780/2002. M.D. Gordillo thanks Interreg Program (through Supermat Network) for financial support.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2006/3/27
Y1 - 2006/3/27
N2 - The supercritical antisolvent (SAS) technique was used to prepare ethyl cellulose/methyl cellulose blends, two biocompatible polymers commonly used as drug carriers in controlled delivery systems. Ethyl cellulose is widely used as a drug carrier. The drug release of the delivery devices can be controlled to some extent by addition of a water-soluble or water swellable polymer, such as methyl cellulose. This leads to the solubility enhancement of poorly water-soluble molecules. SAS experiments were carried out at different operational conditions and microspheres with mean diameters ranging from 5 to 30 μm were obtained. The effect of CO2 and liquid flow, temperature and pressure on particle size and particle size distribution was evaluated. The microspheres were precipitated from a mixture of dichloromethane (DCM) and dimethylsulfoxide (DMSO) (4:1 ratio). The best process conditions for this mixture were according to our study 40°C and 80 bar.
AB - The supercritical antisolvent (SAS) technique was used to prepare ethyl cellulose/methyl cellulose blends, two biocompatible polymers commonly used as drug carriers in controlled delivery systems. Ethyl cellulose is widely used as a drug carrier. The drug release of the delivery devices can be controlled to some extent by addition of a water-soluble or water swellable polymer, such as methyl cellulose. This leads to the solubility enhancement of poorly water-soluble molecules. SAS experiments were carried out at different operational conditions and microspheres with mean diameters ranging from 5 to 30 μm were obtained. The effect of CO2 and liquid flow, temperature and pressure on particle size and particle size distribution was evaluated. The microspheres were precipitated from a mixture of dichloromethane (DCM) and dimethylsulfoxide (DMSO) (4:1 ratio). The best process conditions for this mixture were according to our study 40°C and 80 bar.
KW - Biocompatible polymers
KW - Micronization
KW - Release systems
KW - Supercritical fluid antisolvent (SAS)
UR - http://www.scopus.com/inward/record.url?scp=33644613041&partnerID=8YFLogxK
U2 - 10.1016/j.ijpharm.2005.12.010
DO - 10.1016/j.ijpharm.2005.12.010
M3 - Article
C2 - 16423476
SN - 0378-5173
VL - 311
SP - 50
EP - 54
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 1-2
ER -