Preparation of controlled release microspheres using supercritical fluid technology for delivery of anti-inflammatory drugs

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Abstract

Ethylcellulose/methylcellulose blends were produced using different precipitation techniques and impregnated with naproxen, a non-steroidal anti-inflammatory drug (NSAID). Solvent-evaporation technique was used not only for the preparation of ethylcellulose/methylcellulose microspheres but also to encapsulate naproxen. Supercritical fluid (SCF) impregnation was also performed to prepare naproxen loaded microspheres. The microspheres, impregnated by the SCF technique, were prepared both by solvent-evaporation and by a supercritical antisolvent (SAS) process. In vitro release profiles at pH 7.4 and 1.2, of naproxen-loaded microspheres were evaluated and the results were modelled Fick's law of diffusion and Power law. Miscrospheres prepared by supercritical antisolvent have a higher loading capacity and present a slower release profile. The systems studied present a release mechanism controlled by drug diffusion which complies Fick's law of diffusion. (c) 2005 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)168-174
Number of pages7
JournalInternational Journal of Pharmaceutics
Volume308
Issue number1-2
DOIs
Publication statusPublished - 3 Feb 2006

Keywords

  • SAS
  • Supercritical fluids
  • Anti-inflammatory drugs
  • Controlled delivery systems
  • Ethylcellulose

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