Preparation and Characterization of Injectable Chitosan-Hydroxyapatite Microspheres

P. L. Granja, A. I. N. Silva, J. P. Borges, C. C. Barrias, Isabel Freitas Amaral

Research output: Contribution to journalConference articlepeer-review

23 Citations (Scopus)


The combination of chitosan and hydroxyapatite (HAp) in the form of injectable, porous and biodegradable structures seems to be an interesting route to promote localized bone regeneration, especially with the incorporation of cells or cell-targeted molecules. In the present work, chitosan-HAp microspheres were prepared and characterized in terms of size, morphology, water sorption and structure. Chitosan-HAp porous microspheres were successfully prepared using tripolyphosphate as coagulating agent. The size increased and the water sorption decreased with increasing HAp contents. The ceramic particles were well embedded and homogeneously distributed within the polymer matrix.

Original languageEnglish
Pages (from-to)573-576
Number of pages4
JournalKey Engineering Materials
Publication statusPublished - 9 Jan 2004
EventThe Annual Meeting of the International Society for Ceramics in Medicine - Porto, Portugal
Duration: 6 Nov 20039 Nov 2003


  • Bone regeneration
  • Chitosan
  • Composite
  • Hydroxyapatite
  • Injectable
  • Microsphere


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