Preparation and Characterization of Injectable Chitosan-Hydroxyapatite Microspheres

P. L. Granja; A. I. N. Silva; J. P. Borges; C. C. Barrias; Isabel Freitas Amaral

doi:10.4028/www.scientific.net/KEM.254-256.573

Preparation and Characterization of Injectable Chitosan-Hydroxyapatite Microspheres

P. L. Granja, A. I. N. Silva, J. P. Borges, C. C. Barrias, Isabel Freitas Amaral

DCM - Departamento de Ciência dos Materiais

Research output: Contribution to journal › Conference article › peer-review

25 Citations (Scopus)

Abstract

The combination of chitosan and hydroxyapatite (HAp) in the form of injectable, porous and biodegradable structures seems to be an interesting route to promote localized bone regeneration, especially with the incorporation of cells or cell-targeted molecules. In the present work, chitosan-HAp microspheres were prepared and characterized in terms of size, morphology, water sorption and structure. Chitosan-HAp porous microspheres were successfully prepared using tripolyphosphate as coagulating agent. The size increased and the water sorption decreased with increasing HAp contents. The ceramic particles were well embedded and homogeneously distributed within the polymer matrix.

Original language	English
Pages (from-to)	573-576
Number of pages	4
Journal	Key Engineering Materials
Volume	254-256
DOIs	https://doi.org/10.4028/www.scientific.net/KEM.254-256.573
Publication status	Published - 9 Jan 2004
Event	The Annual Meeting of the International Society for Ceramics in Medicine - Porto, Portugal Duration: 6 Nov 2003 → 9 Nov 2003

Keywords

Bone regeneration
Chitosan
Composite
Hydroxyapatite
Injectable
Microsphere

Access to Document

10.4028/www.scientific.net/KEM.254-256.573

Cite this

@article{dd777181989a454086c9b42bd0f18b71,

title = "Preparation and Characterization of Injectable Chitosan-Hydroxyapatite Microspheres",

abstract = "The combination of chitosan and hydroxyapatite (HAp) in the form of injectable, porous and biodegradable structures seems to be an interesting route to promote localized bone regeneration, especially with the incorporation of cells or cell-targeted molecules. In the present work, chitosan-HAp microspheres were prepared and characterized in terms of size, morphology, water sorption and structure. Chitosan-HAp porous microspheres were successfully prepared using tripolyphosphate as coagulating agent. The size increased and the water sorption decreased with increasing HAp contents. The ceramic particles were well embedded and homogeneously distributed within the polymer matrix.",

keywords = "Bone regeneration, Chitosan, Composite, Hydroxyapatite, Injectable, Microsphere",

author = "Granja, {P. L.} and Silva, {A. I. N.} and Borges, {J. P.} and Barrias, {C. C.} and Amaral, {Isabel Freitas}",

year = "2004",

month = jan,

day = "9",

doi = "10.4028/www.scientific.net/KEM.254-256.573",

language = "English",

volume = "254-256",

pages = "573--576",

journal = "Key Engineering Materials",

issn = "1013-9826",

publisher = "Trans Tech Publications",

note = "The Annual Meeting of the International Society for Ceramics in Medicine ; Conference date: 06-11-2003 Through 09-11-2003",

}

TY - JOUR

T1 - Preparation and Characterization of Injectable Chitosan-Hydroxyapatite Microspheres

AU - Granja, P. L.

AU - Silva, A. I. N.

AU - Borges, J. P.

AU - Barrias, C. C.

AU - Amaral, Isabel Freitas

PY - 2004/1/9

Y1 - 2004/1/9

N2 - The combination of chitosan and hydroxyapatite (HAp) in the form of injectable, porous and biodegradable structures seems to be an interesting route to promote localized bone regeneration, especially with the incorporation of cells or cell-targeted molecules. In the present work, chitosan-HAp microspheres were prepared and characterized in terms of size, morphology, water sorption and structure. Chitosan-HAp porous microspheres were successfully prepared using tripolyphosphate as coagulating agent. The size increased and the water sorption decreased with increasing HAp contents. The ceramic particles were well embedded and homogeneously distributed within the polymer matrix.

AB - The combination of chitosan and hydroxyapatite (HAp) in the form of injectable, porous and biodegradable structures seems to be an interesting route to promote localized bone regeneration, especially with the incorporation of cells or cell-targeted molecules. In the present work, chitosan-HAp microspheres were prepared and characterized in terms of size, morphology, water sorption and structure. Chitosan-HAp porous microspheres were successfully prepared using tripolyphosphate as coagulating agent. The size increased and the water sorption decreased with increasing HAp contents. The ceramic particles were well embedded and homogeneously distributed within the polymer matrix.

KW - Bone regeneration

KW - Chitosan

KW - Composite

KW - Hydroxyapatite

KW - Injectable

KW - Microsphere

UR - http://www.scopus.com/inward/record.url?scp=0346885566&partnerID=8YFLogxK

U2 - 10.4028/www.scientific.net/KEM.254-256.573

DO - 10.4028/www.scientific.net/KEM.254-256.573

M3 - Conference article

AN - SCOPUS:0346885566

SN - 1013-9826

VL - 254-256

SP - 573

EP - 576

JO - Key Engineering Materials

JF - Key Engineering Materials

T2 - The Annual Meeting of the International Society for Ceramics in Medicine

Y2 - 6 November 2003 through 9 November 2003

ER -

Preparation and Characterization of Injectable Chitosan-Hydroxyapatite Microspheres

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this