Prediction of short-term prognosis in elderly patients with spontaneous intracerebral hemorrhage

António Batista, Rui Osório, Ana Varela, Patrícia Guilherme, Ana Marreiros, Sandra Pais, Hipólito Nzwalo

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Aim: The incidence of spontaneous intracerebral hemorrhage (SICH) increases with age. Data on SICH mortality in the very old are sparse. We aimed to describe the predictors of 30-day SICH mortality in the very elderly in southern Portugal. Methods: A total of 256 community representative SICH patients aged ≥ 75 years (2009–2016) were included. Multiple logistic regression was used to identify predictors of 30-day mortality. Results: Mean age was 82.1 years; 57.4% males. The 30-day case fatality was 38.7%. The frequency of patients taking anticoagulants (29.3% vs. 11.5%); comatose (46.9% vs. 2.5%); with hematoma volume ≥ 30 mL (64.6% vs. 13.4%); intraventricular dissection (78.8% vs. 27.4%) was higher in deceased patients (p < 0.05). Survivors were more often admitted to stroke unit (SU) (68.2 vs. 31.3%) and had lower mean admission glycaemia values (p < 0.05). The likelihood of death was increased in patients with higher admission hematoma volume (≥ 30 mL) (OR: 8.817, CI 1.753–44.340, p = 0.008) and with prior to SICH history of ≥ 2 hospitalizations OR = 1.022, CI 1.009–1.069, p = 0.031). Having higher Glasgow coma scale score, OR: 0.522, CI 0.394–0.692, p < 0.001, per unit was associated with reduced risk of death. Age was not an independent risk factor of short-term death. Conclusions: The short-term mortality is high in very elderly SICH. Prior to SICH history of hospitalization, an indirect and gross marker of coexistent functional reserve, not age per se, increases the risk of short-term death. Other predictors of short-term death are potentially manageable reinforcing the message against any defeatist attitude toward elderly patients with SICH.

Original languageEnglish
Pages (from-to)1267 - 1273
JournalEuropean Geriatric Medicine
Issue number6
Early online date2021
Publication statusPublished - Dec 2021


  • Intracerebral hemorrhage
  • Mortality
  • Old
  • Oldest
  • Prognosis


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