POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy

Rita B. Restani; Rita F. Pires; Anna Tolmatcheva; Rita Cabral; Pedro V. Baptista; Alexandra R. Fernandes; Teresa Casimiro; Vasco D. B. Bonifácio; Ana Aguiar-Ricardo

doi:10.1002/open.201800093

POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy

Rita B. Restani, Rita F. Pires, Anna Tolmatcheva, Rita Cabral, Pedro V. Baptista, Alexandra R. Fernandes, Teresa Casimiro, Vasco D. B. Bonifácio, Ana Aguiar-Ricardo

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Abstract

POxylated polyurea dendrimer (PURE_G4OOx₄₈)-based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO₂-assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were produced to effectively transport and deliver the chemotherapeutics with a controlled rate to the deep lung. In vitro studies performed with the use of the lung adenocarcinoma cell line showed that DOX@PURE_G4OOx₄₈ nanoparticles were much more cytotoxic than the free drug. Additionally, the DPFs did not show higher cytotoxicity than the respective nanoparticles, and DOX-DPFs showed a higher chemotherapeutic effect than PTX formulations in adenocarcinoma cells.

Original language	English
Pages (from-to)	772-779
Number of pages	8
Journal	ChemistryOpen
Volume	7
Issue number	10
DOIs	https://doi.org/10.1002/open.201800093
Publication status	Published - 1 Oct 2018

Keywords

chemotherapy
composite particles
dendrimers
drug delivery
pulmonary delivery

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Restani_et_al-2018-ChemistryOpenFinal published version, 1.05 MBLicence: CC BY-NC-ND

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@article{f3571b5bbe1f4dcd8d5bd0ef4150786a,

title = "POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy",

abstract = "POxylated polyurea dendrimer (PUREG4OOx48)-based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO2-assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were produced to effectively transport and deliver the chemotherapeutics with a controlled rate to the deep lung. In vitro studies performed with the use of the lung adenocarcinoma cell line showed that DOX@PUREG4OOx48 nanoparticles were much more cytotoxic than the free drug. Additionally, the DPFs did not show higher cytotoxicity than the respective nanoparticles, and DOX-DPFs showed a higher chemotherapeutic effect than PTX formulations in adenocarcinoma cells.",

keywords = "chemotherapy, composite particles, dendrimers, drug delivery, pulmonary delivery",

author = "Restani, {Rita B.} and Pires, {Rita F.} and Anna Tolmatcheva and Rita Cabral and Baptista, {Pedro V.} and Fernandes, {Alexandra R.} and Teresa Casimiro and Bonif{\'a}cio, {Vasco D. B.} and Ana Aguiar-Ricardo",

note = "Sem PDF conforme despacho. info:eu-repo/grantAgreement/FCT/5876/147218/PT# info:eu-repo/grantAgreement/FCT/5876/147258/PT# info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F66858%2F2009/PT# This work was supported by the Associate Laboratory for Green Chemistry-LAQV, which is financed by national funds from FCT/MCTES (UID/QUI/50006/2013) and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER -007265), the Unidade de Cithornncias Biomoleculares Aplicadas UCIBIO-REQUIMTE, which is financed by national funds from FCT/MEC (UID/Multi/04378/2013) and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007728). The authors acknowledge the Ph.D. grants SFRH/BD/66858/2009 (R.B.R.) and SFRH/BD/109006/2015 (R.F.P.). T.C. also acknowledges FCT-Lisbon for the IF/00915/2014 contract.",

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doi = "10.1002/open.201800093",

language = "English",

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T1 - POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy

AU - Restani, Rita B.

AU - Pires, Rita F.

AU - Tolmatcheva, Anna

AU - Cabral, Rita

AU - Baptista, Pedro V.

AU - Fernandes, Alexandra R.

AU - Casimiro, Teresa

AU - Bonifácio, Vasco D. B.

AU - Aguiar-Ricardo, Ana

N1 - Sem PDF conforme despacho. info:eu-repo/grantAgreement/FCT/5876/147218/PT# info:eu-repo/grantAgreement/FCT/5876/147258/PT# info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F66858%2F2009/PT# This work was supported by the Associate Laboratory for Green Chemistry-LAQV, which is financed by national funds from FCT/MCTES (UID/QUI/50006/2013) and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER -007265), the Unidade de Cithornncias Biomoleculares Aplicadas UCIBIO-REQUIMTE, which is financed by national funds from FCT/MEC (UID/Multi/04378/2013) and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007728). The authors acknowledge the Ph.D. grants SFRH/BD/66858/2009 (R.B.R.) and SFRH/BD/109006/2015 (R.F.P.). T.C. also acknowledges FCT-Lisbon for the IF/00915/2014 contract.

PY - 2018/10/1

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N2 - POxylated polyurea dendrimer (PUREG4OOx48)-based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO2-assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were produced to effectively transport and deliver the chemotherapeutics with a controlled rate to the deep lung. In vitro studies performed with the use of the lung adenocarcinoma cell line showed that DOX@PUREG4OOx48 nanoparticles were much more cytotoxic than the free drug. Additionally, the DPFs did not show higher cytotoxicity than the respective nanoparticles, and DOX-DPFs showed a higher chemotherapeutic effect than PTX formulations in adenocarcinoma cells.

AB - POxylated polyurea dendrimer (PUREG4OOx48)-based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO2-assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were produced to effectively transport and deliver the chemotherapeutics with a controlled rate to the deep lung. In vitro studies performed with the use of the lung adenocarcinoma cell line showed that DOX@PUREG4OOx48 nanoparticles were much more cytotoxic than the free drug. Additionally, the DPFs did not show higher cytotoxicity than the respective nanoparticles, and DOX-DPFs showed a higher chemotherapeutic effect than PTX formulations in adenocarcinoma cells.

KW - chemotherapy

KW - composite particles

KW - dendrimers

KW - drug delivery

KW - pulmonary delivery

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M3 - Article

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SN - 2191-1363

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EP - 779

JO - ChemistryOpen

JF - ChemistryOpen

IS - 10

ER -

POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy

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Keywords

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