Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities

Marta Martins; Sujata G. Dastidar; Seamus Fanning; Jette E. Kristiansen; Joseph Molnar; Jean-Marie Pages; Zsuzsanna Schelz; Gabriella Spengler; Miguel Viveiros; Leonard Amaral

doi:10.1016/j.ijantimicag.2007.10.025

Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities

Marta Martins, Sujata G. Dastidar, Seamus Fanning, Jette E. Kristiansen, Joseph Molnar, Jean-Marie Pages, Zsuzsanna Schelz, Gabriella Spengler, Miguel Viveiros, Leonard Amaral

Research output: Contribution to journal › Review article

Abstract

Multidrug resistance in Gram-negative bacteria is now known to be primarily caused by overexpression of efflux pumps that extrude unrelated antibiotics from the periplasm or cytoplasm of the bacterium prior to their reaching their intended target. This review focuses on a variety of agents that have been shown to be efflux pump inhibitors (EPIs) and which, if used as 'helper compounds' in combination with antibiotics to which the organism is initially resistant, may produce the required cure. Although not all of the EPIs may serve a helper role owing to their toxicity, they may nevertheless serve as lead compounds.

Original language	English
Pages (from-to)	198-208
Number of pages	11
Journal	International Journal Of Antimicrobial Agents
Volume	Vol. 31
Issue number	n.º 3
DOIs	https://doi.org/10.1016/j.ijantimicag.2007.10.025
Publication status	Published - Mar 2008

Keywords

Multidrug resistance
Gram-negative bacteria
Efflux pumps
Efflux pump inhibitors
Non-antibiotics
Helper compounds
Staphylococcus-aureus mrsa
CA2+-activated K+ Channel
Escherichia-coli
Mycobacterium-tuberculosis
In-Vitro
Campylobacter-jejuni
Antimicrobial resistance
Antitubercular activity
Outer-membrane

UN Sustainable Development Goals (SDGs)

SDG 3 - Good Health and Well-Being

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10.1016/j.ijantimicag.2007.10.025

Cite this

Martins, M., Dastidar, S. G., Fanning, S., Kristiansen, J. E., Molnar, J., Pages, J-M., Schelz, Z., Spengler, G., Viveiros, M., & Amaral, L. (2008). Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities. International Journal Of Antimicrobial Agents, Vol. 31(n.º 3), 198-208. https://doi.org/10.1016/j.ijantimicag.2007.10.025

Martins, Marta ; Dastidar, Sujata G. ; Fanning, Seamus ; Kristiansen, Jette E. ; Molnar, Joseph ; Pages, Jean-Marie ; Schelz, Zsuzsanna ; Spengler, Gabriella ; Viveiros, Miguel ; Amaral, Leonard. / Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities. In: International Journal Of Antimicrobial Agents. 2008 ; Vol. Vol. 31, No. n.º 3. pp. 198-208.

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title = "Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities",

abstract = "Multidrug resistance in Gram-negative bacteria is now known to be primarily caused by overexpression of efflux pumps that extrude unrelated antibiotics from the periplasm or cytoplasm of the bacterium prior to their reaching their intended target. This review focuses on a variety of agents that have been shown to be efflux pump inhibitors (EPIs) and which, if used as 'helper compounds' in combination with antibiotics to which the organism is initially resistant, may produce the required cure. Although not all of the EPIs may serve a helper role owing to their toxicity, they may nevertheless serve as lead compounds. ",

keywords = "Multidrug resistance, Gram-negative bacteria, Efflux pumps, Efflux pump inhibitors, Non-antibiotics, Helper compounds, Staphylococcus-aureus mrsa, CA2+-activated K+ Channel, Escherichia-coli, Mycobacterium-tuberculosis, In-Vitro, Campylobacter-jejuni, Antimicrobial resistance, Antitubercular activity, Outer-membrane",

author = "Marta Martins and Dastidar, {Sujata G.} and Seamus Fanning and Kristiansen, {Jette E.} and Joseph Molnar and Jean-Marie Pages and Zsuzsanna Schelz and Gabriella Spengler and Miguel Viveiros and Leonard Amaral",

year = "2008",

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Martins, M, Dastidar, SG, Fanning, S, Kristiansen, JE, Molnar, J, Pages, J-M, Schelz, Z, Spengler, G, Viveiros, M & Amaral, L 2008, 'Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities', International Journal Of Antimicrobial Agents, vol. Vol. 31, no. n.º 3, pp. 198-208. https://doi.org/10.1016/j.ijantimicag.2007.10.025

Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities. / Martins, Marta; Dastidar, Sujata G.; Fanning, Seamus; Kristiansen, Jette E.; Molnar, Joseph; Pages, Jean-Marie; Schelz, Zsuzsanna; Spengler, Gabriella; Viveiros, Miguel ; Amaral, Leonard.

In: International Journal Of Antimicrobial Agents, Vol. Vol. 31, No. n.º 3, 03.2008, p. 198-208.

Research output: Contribution to journal › Review article

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AU - Martins, Marta

AU - Dastidar, Sujata G.

AU - Fanning, Seamus

AU - Kristiansen, Jette E.

AU - Molnar, Joseph

AU - Pages, Jean-Marie

AU - Schelz, Zsuzsanna

AU - Spengler, Gabriella

AU - Viveiros, Miguel

AU - Amaral, Leonard

PY - 2008/3

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KW - CA2+-activated K+ Channel

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KW - Antimicrobial resistance

KW - Antitubercular activity

KW - Outer-membrane

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VL - Vol. 31

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JO - International Journal Of Antimicrobial Agents

JF - International Journal Of Antimicrobial Agents

SN - 0924-8579

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Martins M, Dastidar SG, Fanning S, Kristiansen JE, Molnar J, Pages J-M et al. Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities. International Journal Of Antimicrobial Agents. 2008 Mar;Vol. 31(n.º 3):198-208. https://doi.org/10.1016/j.ijantimicag.2007.10.025