TY - JOUR
T1 - Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities
AU - Martins, Marta
AU - Dastidar, Sujata G.
AU - Fanning, Seamus
AU - Kristiansen, Jette E.
AU - Molnar, Joseph
AU - Pages, Jean-Marie
AU - Schelz, Zsuzsanna
AU - Spengler, Gabriella
AU - Viveiros, Miguel
AU - Amaral, Leonard
PY - 2008/3
Y1 - 2008/3
N2 - Multidrug resistance in Gram-negative bacteria is now known to be primarily caused by overexpression of efflux pumps that extrude unrelated antibiotics from the periplasm or cytoplasm of the bacterium prior to their reaching their intended target. This review focuses on a variety of agents that have been shown to be efflux pump inhibitors (EPIs) and which, if used as 'helper compounds' in combination with antibiotics to which the organism is initially resistant, may produce the required cure. Although not all of the EPIs may serve a helper role owing to their toxicity, they may nevertheless serve as lead compounds.
AB - Multidrug resistance in Gram-negative bacteria is now known to be primarily caused by overexpression of efflux pumps that extrude unrelated antibiotics from the periplasm or cytoplasm of the bacterium prior to their reaching their intended target. This review focuses on a variety of agents that have been shown to be efflux pump inhibitors (EPIs) and which, if used as 'helper compounds' in combination with antibiotics to which the organism is initially resistant, may produce the required cure. Although not all of the EPIs may serve a helper role owing to their toxicity, they may nevertheless serve as lead compounds.
KW - Multidrug resistance
KW - Gram-negative bacteria
KW - Efflux pumps
KW - Efflux pump inhibitors
KW - Non-antibiotics
KW - Helper compounds
KW - Staphylococcus-aureus mrsa
KW - CA2+-activated K+ Channel
KW - Escherichia-coli
KW - Mycobacterium-tuberculosis
KW - In-Vitro
KW - Campylobacter-jejuni
KW - Antimicrobial resistance
KW - Antitubercular activity
KW - Outer-membrane
UR - http://www.scopus.com/inward/record.url?scp=39149121434&partnerID=8YFLogxK
UR - https://www.sciencedirect.com/science/article/abs/pii/S0924857907005572?via%3Dihub
U2 - 10.1016/j.ijantimicag.2007.10.025
DO - 10.1016/j.ijantimicag.2007.10.025
M3 - Review article
C2 - 18180147
SN - 0924-8579
VL - Vol. 31
SP - 198
EP - 208
JO - International Journal Of Antimicrobial Agents
JF - International Journal Of Antimicrobial Agents
IS - n.º 3
ER -