Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities

Marta Martins; Sujata G. Dastidar; Seamus Fanning; Jette E. Kristiansen; Joseph Molnar; Jean-Marie Pages; Zsuzsanna Schelz; Gabriella Spengler; Miguel Viveiros; Leonard Amaral

doi:10.1016/j.ijantimicag.2007.10.025

Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities

Marta Martins, Sujata G. Dastidar, Seamus Fanning, Jette E. Kristiansen, Joseph Molnar, Jean-Marie Pages, Zsuzsanna Schelz, Gabriella Spengler, Miguel Viveiros, Leonard Amaral

Research output: Contribution to journal › Review article › peer-review

Abstract

Multidrug resistance in Gram-negative bacteria is now known to be primarily caused by overexpression of efflux pumps that extrude unrelated antibiotics from the periplasm or cytoplasm of the bacterium prior to their reaching their intended target. This review focuses on a variety of agents that have been shown to be efflux pump inhibitors (EPIs) and which, if used as 'helper compounds' in combination with antibiotics to which the organism is initially resistant, may produce the required cure. Although not all of the EPIs may serve a helper role owing to their toxicity, they may nevertheless serve as lead compounds.

Original language	English
Pages (from-to)	198-208
Number of pages	11
Journal	International Journal Of Antimicrobial Agents
Volume	Vol. 31
Issue number	n.º 3
DOIs	https://doi.org/10.1016/j.ijantimicag.2007.10.025
Publication status	Published - Mar 2008

Keywords

Multidrug resistance
Gram-negative bacteria
Efflux pumps
Efflux pump inhibitors
Non-antibiotics
Helper compounds
Staphylococcus-aureus mrsa
CA2+-activated K+ Channel
Escherichia-coli
Mycobacterium-tuberculosis
In-Vitro
Campylobacter-jejuni
Antimicrobial resistance
Antitubercular activity
Outer-membrane

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ijantimicag.2007.10.025

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Martins, M., Dastidar, S. G., Fanning, S., Kristiansen, J. E., Molnar, J., Pages, J-M., Schelz, Z., Spengler, G., Viveiros, M., & Amaral, L. (2008). Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities. International Journal Of Antimicrobial Agents, Vol. 31(n.º 3), 198-208. https://doi.org/10.1016/j.ijantimicag.2007.10.025

Martins, Marta ; Dastidar, Sujata G. ; Fanning, Seamus ; Kristiansen, Jette E. ; Molnar, Joseph ; Pages, Jean-Marie ; Schelz, Zsuzsanna ; Spengler, Gabriella ; Viveiros, Miguel ; Amaral, Leonard. / Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities. In: International Journal Of Antimicrobial Agents. 2008 ; Vol. Vol. 31, No. n.º 3. pp. 198-208.

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title = "Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities",

abstract = "Multidrug resistance in Gram-negative bacteria is now known to be primarily caused by overexpression of efflux pumps that extrude unrelated antibiotics from the periplasm or cytoplasm of the bacterium prior to their reaching their intended target. This review focuses on a variety of agents that have been shown to be efflux pump inhibitors (EPIs) and which, if used as 'helper compounds' in combination with antibiotics to which the organism is initially resistant, may produce the required cure. Although not all of the EPIs may serve a helper role owing to their toxicity, they may nevertheless serve as lead compounds. ",

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author = "Marta Martins and Dastidar, {Sujata G.} and Seamus Fanning and Kristiansen, {Jette E.} and Joseph Molnar and Jean-Marie Pages and Zsuzsanna Schelz and Gabriella Spengler and Miguel Viveiros and Leonard Amaral",

year = "2008",

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doi = "10.1016/j.ijantimicag.2007.10.025",

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Martins, M, Dastidar, SG, Fanning, S, Kristiansen, JE, Molnar, J, Pages, J-M, Schelz, Z, Spengler, G, Viveiros, M & Amaral, L 2008, 'Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities', International Journal Of Antimicrobial Agents, vol. Vol. 31, no. n.º 3, pp. 198-208. https://doi.org/10.1016/j.ijantimicag.2007.10.025

Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities. / Martins, Marta; Dastidar, Sujata G.; Fanning, Seamus; Kristiansen, Jette E.; Molnar, Joseph; Pages, Jean-Marie; Schelz, Zsuzsanna; Spengler, Gabriella; Viveiros, Miguel ; Amaral, Leonard.

In: International Journal Of Antimicrobial Agents, Vol. Vol. 31, No. n.º 3, 03.2008, p. 198-208.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities

AU - Martins, Marta

AU - Dastidar, Sujata G.

AU - Fanning, Seamus

AU - Kristiansen, Jette E.

AU - Molnar, Joseph

AU - Pages, Jean-Marie

AU - Schelz, Zsuzsanna

AU - Spengler, Gabriella

AU - Viveiros, Miguel

AU - Amaral, Leonard

PY - 2008/3

Y1 - 2008/3

N2 - Multidrug resistance in Gram-negative bacteria is now known to be primarily caused by overexpression of efflux pumps that extrude unrelated antibiotics from the periplasm or cytoplasm of the bacterium prior to their reaching their intended target. This review focuses on a variety of agents that have been shown to be efflux pump inhibitors (EPIs) and which, if used as 'helper compounds' in combination with antibiotics to which the organism is initially resistant, may produce the required cure. Although not all of the EPIs may serve a helper role owing to their toxicity, they may nevertheless serve as lead compounds.

AB - Multidrug resistance in Gram-negative bacteria is now known to be primarily caused by overexpression of efflux pumps that extrude unrelated antibiotics from the periplasm or cytoplasm of the bacterium prior to their reaching their intended target. This review focuses on a variety of agents that have been shown to be efflux pump inhibitors (EPIs) and which, if used as 'helper compounds' in combination with antibiotics to which the organism is initially resistant, may produce the required cure. Although not all of the EPIs may serve a helper role owing to their toxicity, they may nevertheless serve as lead compounds.

KW - Multidrug resistance

KW - Gram-negative bacteria

KW - Efflux pumps

KW - Efflux pump inhibitors

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KW - Helper compounds

KW - Staphylococcus-aureus mrsa

KW - CA2+-activated K+ Channel

KW - Escherichia-coli

KW - Mycobacterium-tuberculosis

KW - In-Vitro

KW - Campylobacter-jejuni

KW - Antimicrobial resistance

KW - Antitubercular activity

KW - Outer-membrane

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U2 - 10.1016/j.ijantimicag.2007.10.025

DO - 10.1016/j.ijantimicag.2007.10.025

M3 - Review article

C2 - 18180147

VL - Vol. 31

SP - 198

EP - 208

JO - International Journal Of Antimicrobial Agents

JF - International Journal Of Antimicrobial Agents

SN - 0924-8579

IS - n.º 3

ER -

Martins M, Dastidar SG, Fanning S, Kristiansen JE, Molnar J, Pages J-M et al. Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities. International Journal Of Antimicrobial Agents. 2008 Mar;Vol. 31(n.º 3):198-208. https://doi.org/10.1016/j.ijantimicag.2007.10.025

Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities

Abstract

Keywords

UN SDGs

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