Potential dementia biomarkers based on the time-varying micro structure of sleep EEG spindles

P. Y. Ktonas; S. Golemati; P. Xanthopoulos; V. Sakkalis; M. D. Ortigueira; H. Tsekou; M. Zervakis; T. Paparrigopoulos; C. R. Soldates

doi:10.1109/IEMBS.2007.4352827

Potential dementia biomarkers based on the time-varying micro structure of sleep EEG spindles

P. Y. Ktonas, S. Golemati, P. Xanthopoulos, V. Sakkalis, M. D. Ortigueira, H. Tsekou, M. Zervakis, T. Paparrigopoulos, C. R. Soldates

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

20 Citations (Scopus)

Abstract

The time-varying microstructure of sleep EEG spindles may have clinical significance in dementia studies. In this work, the sleep spindle is modeled as an AM-FM signal and parameterized in terms of six parameters, three quantifying the instantaneous envelope (IE) and three quantifying the instantaneous frequency (IF) of the spindle model. The IE and IF waveforms of sleep spindles from patients with dementia and normal controls were estimated using the time-frequency technique of Complex Demodulation (CD). Sinusoidal curve-fitting using a matching pursuit (MP) approach was applied to the IE and IF waveforms for the estimation of the six model parameters. Specific differences were found in sleep spindle instantaneous frequency dynamics between spindles from dementia subjects and spindles from controls.

Original language	English
Title of host publication	29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07
Pages	2464-2467
Number of pages	4
DOIs	https://doi.org/10.1109/IEMBS.2007.4352827
Publication status	Published - 2007
Event	29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07 - Lyon, France Duration: 23 Aug 2007 → 26 Aug 2007

Conference

Conference	29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07
Country/Territory	France
City	Lyon
Period	23/08/07 → 26/08/07

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10.1109/IEMBS.2007.4352827

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Ktonas, P. Y., Golemati, S., Xanthopoulos, P., Sakkalis, V., Ortigueira, M. D., Tsekou, H., Zervakis, M., Paparrigopoulos, T., & Soldates, C. R. (2007). Potential dementia biomarkers based on the time-varying micro structure of sleep EEG spindles. In 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07 (pp. 2464-2467). Article 4352827 https://doi.org/10.1109/IEMBS.2007.4352827

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abstract = "The time-varying microstructure of sleep EEG spindles may have clinical significance in dementia studies. In this work, the sleep spindle is modeled as an AM-FM signal and parameterized in terms of six parameters, three quantifying the instantaneous envelope (IE) and three quantifying the instantaneous frequency (IF) of the spindle model. The IE and IF waveforms of sleep spindles from patients with dementia and normal controls were estimated using the time-frequency technique of Complex Demodulation (CD). Sinusoidal curve-fitting using a matching pursuit (MP) approach was applied to the IE and IF waveforms for the estimation of the six model parameters. Specific differences were found in sleep spindle instantaneous frequency dynamics between spindles from dementia subjects and spindles from controls.",

author = "Ktonas, {P. Y.} and S. Golemati and P. Xanthopoulos and V. Sakkalis and Ortigueira, {M. D.} and H. Tsekou and M. Zervakis and T. Paparrigopoulos and Soldates, {C. R.}",

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doi = "10.1109/IEMBS.2007.4352827",

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booktitle = "29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07",

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Ktonas, PY, Golemati, S, Xanthopoulos, P, Sakkalis, V, Ortigueira, MD, Tsekou, H, Zervakis, M, Paparrigopoulos, T & Soldates, CR 2007, Potential dementia biomarkers based on the time-varying micro structure of sleep EEG spindles. in 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07., 4352827, pp. 2464-2467, 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07, Lyon, France, 23/08/07. https://doi.org/10.1109/IEMBS.2007.4352827

Potential dementia biomarkers based on the time-varying micro structure of sleep EEG spindles. / Ktonas, P. Y.; Golemati, S.; Xanthopoulos, P. et al.
29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07. 2007. p. 2464-2467 4352827.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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Potential dementia biomarkers based on the time-varying micro structure of sleep EEG spindles

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