Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells

Cheila Rocha, Joana Duarte, Pedro Borrego, Rita Calado, José Maria Marcelino, Rita Tendeiro, Emília Valadas, Ana Espada Sousa, Nuno Taveira

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Potent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. We found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 infection. Thus, HIV antibody affinity maturation is linked to memory B-cell exhaustion even in reduced viremia settings.

Original languageEnglish
Pages (from-to)2431-2433
Number of pages3
JournalAIDS
Volume31
Issue number17
DOIs
Publication statusPublished - 13 Nov 2017

Fingerprint

HIV-2
Memory Disorders
HIV Antibodies
B-Lymphocytes
Viremia
Neutralizing Antibodies
HIV Infections
Antibodies
Antibody Affinity
Vaccination
HIV

Keywords

  • Human immunodeficiency virus antibody
  • neutralizing antibody
  • antibody affinity
  • antigen binding
  • antiviral therapy
  • Article
  • CD4+ T lymphocyte
  • cell maturation

Cite this

Rocha, C., Duarte, J., Borrego, P., Calado, R., Marcelino, J. M., Tendeiro, R., ... Taveira, N. (2017). Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells. AIDS, 31(17), 2431-2433. https://doi.org/10.1097/QAD.0000000000001661
Rocha, Cheila ; Duarte, Joana ; Borrego, Pedro ; Calado, Rita ; Marcelino, José Maria ; Tendeiro, Rita ; Valadas, Emília ; Sousa, Ana Espada ; Taveira, Nuno. / Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells. In: AIDS. 2017 ; Vol. 31, No. 17. pp. 2431-2433.
@article{a922852368e54bb1a114d06d2035d410,
title = "Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells",
abstract = "Potent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. We found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 infection. Thus, HIV antibody affinity maturation is linked to memory B-cell exhaustion even in reduced viremia settings.",
keywords = "Human immunodeficiency virus antibody, neutralizing antibody, antibody affinity, antigen binding, antiviral therapy, Article, CD4+ T lymphocyte, cell maturation",
author = "Cheila Rocha and Joana Duarte and Pedro Borrego and Rita Calado and Marcelino, {Jos{\'e} Maria} and Rita Tendeiro and Em{\'i}lia Valadas and Sousa, {Ana Espada} and Nuno Taveira",
year = "2017",
month = "11",
day = "13",
doi = "10.1097/QAD.0000000000001661",
language = "English",
volume = "31",
pages = "2431--2433",
journal = "AIDS",
issn = "0269-9370",
publisher = "LIPPINCOTT WILLIAMS & WILKINS",
number = "17",

}

Rocha, C, Duarte, J, Borrego, P, Calado, R, Marcelino, JM, Tendeiro, R, Valadas, E, Sousa, AE & Taveira, N 2017, 'Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells', AIDS, vol. 31, no. 17, pp. 2431-2433. https://doi.org/10.1097/QAD.0000000000001661

Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells. / Rocha, Cheila; Duarte, Joana; Borrego, Pedro; Calado, Rita; Marcelino, José Maria; Tendeiro, Rita; Valadas, Emília; Sousa, Ana Espada; Taveira, Nuno.

In: AIDS, Vol. 31, No. 17, 13.11.2017, p. 2431-2433.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells

AU - Rocha, Cheila

AU - Duarte, Joana

AU - Borrego, Pedro

AU - Calado, Rita

AU - Marcelino, José Maria

AU - Tendeiro, Rita

AU - Valadas, Emília

AU - Sousa, Ana Espada

AU - Taveira, Nuno

PY - 2017/11/13

Y1 - 2017/11/13

N2 - Potent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. We found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 infection. Thus, HIV antibody affinity maturation is linked to memory B-cell exhaustion even in reduced viremia settings.

AB - Potent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. We found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 infection. Thus, HIV antibody affinity maturation is linked to memory B-cell exhaustion even in reduced viremia settings.

KW - Human immunodeficiency virus antibody

KW - neutralizing antibody

KW - antibody affinity

KW - antigen binding

KW - antiviral therapy

KW - Article

KW - CD4+ T lymphocyte

KW - cell maturation

UR - http://www.scopus.com/inward/record.url?scp=85034061405&partnerID=8YFLogxK

U2 - 10.1097/QAD.0000000000001661

DO - 10.1097/QAD.0000000000001661

M3 - Article

VL - 31

SP - 2431

EP - 2433

JO - AIDS

JF - AIDS

SN - 0269-9370

IS - 17

ER -