Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells

Cheila Rocha, Joana Duarte, Pedro Borrego, Rita Calado, José Maria Marcelino, Rita Tendeiro, Emília Valadas, Ana Espada Sousa, Nuno Taveira

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Abstract

Potent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. We found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 infection. Thus, HIV antibody affinity maturation is linked to memory B-cell exhaustion even in reduced viremia settings.

Original languageEnglish
Pages (from-to)2431-2433
Number of pages3
JournalAIDS
Volume31
Issue number17
DOIs
Publication statusPublished - 13 Nov 2017

Keywords

  • Human immunodeficiency virus antibody
  • neutralizing antibody
  • antibody affinity
  • antigen binding
  • antiviral therapy
  • Article
  • CD4+ T lymphocyte
  • cell maturation

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    Rocha, C., Duarte, J., Borrego, P., Calado, R., Marcelino, J. M., Tendeiro, R., ... Taveira, N. (2017). Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells. AIDS, 31(17), 2431-2433. https://doi.org/10.1097/QAD.0000000000001661