Population structure of a vector of human diseases: Aedes aegypti in its ancestral range, Africa

Panayiota Kotsakiozi, Benjamin R. Evans, Andrea Gloria-Soria, Basile Kamgang, Martin Mayanja, Julius Lutwama, Gilbert Le Goff, Diego Ayala, Christophe Paupy, Athanase Badolo, Joao Pinto, Carla A. Sousa, Arlete D. Troco, Jeffrey R. Powell

Research output: Contribution to journalArticle

Abstract

Aedes aegypti, the major vector of dengue, yellow fever, chikungunya, and Zika viruses, remains of great medical and public health concern. There is little doubt thatthe ancestral home of the species is Africa. This mosquito invaded the New World400-500 years ago and later, Asia. However, little is known about the genetic structure and history of Ae. aegypti across Africa, as well as the possible origin(s) of theNew World invasion. Here, we use ∼17,000 genome-wide single nucleotide polymorphisms (SNPs) to characterize a heretofore undocumented complex picture of thismosquito across its ancestral range in Africa. We find signatures of human-assistedmigrations, connectivity across long distances in sylvan populations, and of local admixture between domestic and sylvan populations. Finally, through a phylogeneticanalysis combined with the genetic structure analyses, we suggest West Africa andespecially Angola as the source of the New World's invasion, a scenario that fits wellwith the historic record of 16th-century slave trade between Africa and Americas.

Original languageEnglish
Pages (from-to)7835-7848
Number of pages14
JournalInternational Journal of Business Innovation and Research
Volume17
Issue number3
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Aedes aegypti
  • Africa
  • Genetics
  • Migration
  • Population structure
  • SNP-chip

UN Sustainable Development Goals (SDGs)

  • SDG 3 - Good Health and Well-Being
  • SDG 15 - Life on Land

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