Popular edible seaweed, Gelidium amansii prevents against diet-induced obesity.

Min-Cheol C Kang, Nalae Kang, Seo-Young Y Kim, Inês S Lima, Seok-Chun C Ko, Young-Tae Young-Bum B T Kim, Young-Tae Young-Bum B T Kim, Hee-Do D Jeung, Kwang-Sik S Choi, You-Jin J Jeon

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

The popular edible seaweed, Gelidium amansii is broadly used as food worldwide. To determine whether G. amansii extract (GAE) has protective effects on obesity, mice fed a high-fat diet (HFD) treated with GAE (1 and 3 %) were studied. After 12 weeks of GAE treatment, body weight was greatly decreased in mice fed a high-fat diet. This effect could be due to decreased adipogenesis, as evidenced by the fact that GAE suppressed adipogenic gene expression in adipocytes. In addition, blood glucose and serum insulin levels were reduced by GAE treatment in mice fed a high-fat diet, suggesting improvement in glucose metabolism. GAE supplementation also led to a significant decrease in total cholesterol and triglyceride levels. These data are further confirmed by HE staining. Our findings indicate that Gelidium amansii prevents against the development of diet-induced obesity, and further implicate that GAE supplementation could be the therapeutical option for treatment of metabolic disorder such as obesity.
Original languageEnglish
Pages (from-to)181-187
Number of pages7
JournalFood and Chemical Toxicology
Volume90
DOIs
Publication statusPublished - Apr 2016

Keywords

  • Adipogenesis
  • Anti-obesity
  • High fat diet
  • Gelidium amansii
  • Edible seaweed

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