POPs’ effect on cardiometabolic and inflammatory profile in a sample of women with obesity and hypertension

Ana Ferro, Diana Teixeira, Diogo Pestana, Rosário Monteiro, Cristina C. Santos, Valentina F. Domingues, Jorge Polónia, Conceição Calhau

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Persistent organic pollutants (POPs) are man-made compounds with metabolic disruption impact. We investigated the effect of POP exposure in the cardiometabolic and inflammatory profile in a population of women with obesity and hypertension. In 43 premenopausal women (22 treated vs. 21 nontreated) undergoing bariatric surgery, blood and adipose tissue samples (visceral (vAT) and abdominal subcutaneous (scAT)) were collected. Median concentrations of ∑HCH and ∑POPs in vAT were significantly higher in treated women. VAT ∑HCH and scAT ∑HCH and ∑POPs concentrations were positively correlated with systolic blood pressure in the non-treated group. Our findings suggest that exposure to POPs and its accumulation in vAT and circulating in plasma may be associated to a higher cardiovascular risk in women with obesity and hypertension, with or without antihypertensive treatment.

Original languageEnglish
Pages (from-to)310-321
JournalArchives of Environmental and Occupational Health
Volume74
Issue number6
DOIs
Publication statusPublished - 2 Nov 2019

Keywords

  • Cardiometabolic risk
  • hypertension
  • inflammation
  • obesity
  • persistent organic pollutants

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