TY - JOUR
T1 - Poly(Thionine)-Modified Screen-Printed Electrodes for CA 19-9 Detection and Its Properties in Raman Spectroscopy
AU - Castaño-Guerrero, Yuselis
AU - Romaguera-Barcelay, Yonny
AU - Moreira, Felismina Teixeira Coelho
AU - Brito, Walter Ricardo
AU - Fortunato, Elvira
AU - Sales, Maria Goreti Ferreira
N1 - Funding Information:
Funding: This research was funded by Fundação para a Ciência e Tecnologia grant number SFRH/BD /145590/2019.
Funding Information:
Acknowledgments: Y.C.-G. acknowledges the PhD grant reference SFRH/BD/145590/2019 to Fundação para a Ciência e Tecnologia.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/2/27
Y1 - 2022/2/27
N2 - Polythionine (PTH) is an electroactive compound known for its excellent electron transfer capacity. It has stable and redox centers in its structure, and it can also be generated by electropoly-merization of thionine (TH). Due to its properties, it has been used in a large number of applications, including the construction of electrochemical biosensors. In this work, PTH is explored for its ability to generate electrons, which allows it to act as an electrochemical probe in a biosensor that detects CA 19-9 on two different substrates, carbon and gold, using differential pulse voltammetry (DPV) as a reading technique in phosphate buffer (PhB). The analytical features of the resulting electrodes are given, showing linear ranges from 0.010 to 10 U/mL. The Raman spectra of PTH films on gold (substrates or nanostars) and carbon (substrates) are also presented and discussed as a potential use for SERS readings as complementary information to electrochemical data.
AB - Polythionine (PTH) is an electroactive compound known for its excellent electron transfer capacity. It has stable and redox centers in its structure, and it can also be generated by electropoly-merization of thionine (TH). Due to its properties, it has been used in a large number of applications, including the construction of electrochemical biosensors. In this work, PTH is explored for its ability to generate electrons, which allows it to act as an electrochemical probe in a biosensor that detects CA 19-9 on two different substrates, carbon and gold, using differential pulse voltammetry (DPV) as a reading technique in phosphate buffer (PhB). The analytical features of the resulting electrodes are given, showing linear ranges from 0.010 to 10 U/mL. The Raman spectra of PTH films on gold (substrates or nanostars) and carbon (substrates) are also presented and discussed as a potential use for SERS readings as complementary information to electrochemical data.
KW - CA 19-9
KW - Cancer biomarker
KW - Electrochemistry
KW - Screen-printed electrodes
KW - SERS
KW - Thionine
UR - http://www.scopus.com/inward/record.url?scp=85125797747&partnerID=8YFLogxK
U2 - 10.3390/chemosensors10030092
DO - 10.3390/chemosensors10030092
M3 - Article
AN - SCOPUS:85125797747
SN - 2227-9040
VL - 10
JO - Chemosensors
JF - Chemosensors
IS - 3
M1 - 92
ER -
