Polyphenols, their metabolites and derivatives as drug leads

A. Filipa Almeida, Cláudia Nunes Dos Santos, Maria Rita Ventura

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

In this non-comprehensive review, the potential of natural polyphenols as lead compounds for the design and synthesis of new molecules with potential application in several diseases was highlighted. Organic synthesis has been essential for the development of new analogues of naturally found polyphenols, providing a wide range of structural modifications for structure-activity relationship studies and improving or modulating the biological activity of the promising compounds.

Original languageEnglish
Pages (from-to)2188-2207
Number of pages20
JournalCurrent Pharmaceutical Design
Volume24
Issue number19
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Anticancer
  • Chemical synthesis
  • Drugs
  • Medicinal chemistry
  • Polyphenol metabolites
  • Polyphenols

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