Polyphenols, their metabolites and derivatives as drug leads

A. Filipa Almeida; Cláudia Nunes Dos Santos; Maria Rita Ventura

doi:10.2174/1381612824666180516103609

Polyphenols, their metabolites and derivatives as drug leads

A. Filipa Almeida, Cláudia Nunes Dos Santos, Maria Rita Ventura

Instituto de Tecnologia Química e Biológica António Xavier (ITQB)

Research output: Contribution to journal › Review article

2 Citations (Scopus)

Abstract

In this non-comprehensive review, the potential of natural polyphenols as lead compounds for the design and synthesis of new molecules with potential application in several diseases was highlighted. Organic synthesis has been essential for the development of new analogues of naturally found polyphenols, providing a wide range of structural modifications for structure-activity relationship studies and improving or modulating the biological activity of the promising compounds.

Original language	English
Pages (from-to)	2188-2207
Number of pages	20
Journal	Current Pharmaceutical Design
Volume	24
Issue number	19
DOIs	https://doi.org/10.2174/1381612824666180516103609
Publication status	Published - 1 Jan 2018

Keywords

Anticancer
Chemical synthesis
Drugs
Medicinal chemistry
Polyphenol metabolites
Polyphenols

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10.2174/1381612824666180516103609Licence: CC BY

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KW - Chemical synthesis

KW - Drugs

KW - Medicinal chemistry

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