TY - JOUR
T1 - Polyphenol Iongel Patches with Antimicrobial, Antioxidant and Anti-Inflammatory Properties
AU - Luque, Gisela C.
AU - Moya, Melissa
AU - Picchio, Matias L.
AU - Bagnarello, Vanessa
AU - Valerio, Idalia
AU - Bolaños, José
AU - Vethencourt, María
AU - Gamboa, Sue Hellen
AU - Tomé, Liliana C.
AU - Minari, Roque J.
AU - Mecerreyes, David
N1 - info:eu-repo/grantAgreement/EC/H2020/823989/EU#
info:eu-repo/grantAgreement/FCT/CEEC IND 3ed/2020.01555.CEECIND%2FCP1586%2FCT0034/PT#
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT#
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT#
Funding Information:
The Group of Polymer of INTEC acknowledges the financial support from CONICET (PIP 11220200101353CO), ANPCyT (PICT-2020-SERIE A 2020-03156), and the National University of the Litoral (C.A.I. + D 50620190100117LI).
Publisher Copyright:
© 2023 by the authors.
PY - 2023/2/21
Y1 - 2023/2/21
N2 - There is an actual need for developing materials for wound healing applications with anti-inflammatory, antioxidant, or antibacterial properties in order to improve the healing performance. In this work, we report the preparation and characterization of soft and bioactive iongel materials for patches, based on polymeric poly(vinyl alcohol) (PVA) and four ionic liquids containing the cholinium cation and different phenolic acid anions, namely cholinium salicylate ([Ch][Sal]), cholinium gallate ([Ch][Ga]), cholinium vanillate ([Ch][Van]), and cholinium caffeate ([Ch][Caff]). Within the iongels, the phenolic motif in the ionic liquids plays a dual role, acting as a PVA crosslinker and a bioactive compound. The obtained iongels are flexible, elastic, ionic conducting, and thermoreversible materials. Moreover, the iongels demonstrated high biocompatibility, non-hemolytic activity, and non-agglutination in mice blood, which are key-sought material specifications in wound healing applications. All the iongels have shown antibacterial properties, being PVA-[Ch][Sal], the one with higher inhibition halo for Escherichia Coli. The iongels also revealed high values of antioxidant activity due to the presence of the polyphenol, with the PVA-[Ch][Van] iongel having the highest activity. Finally, the iongels show a decrease in NO production in LPS-stimulated macrophages, with the PVA-[Ch][Sal] iongel displaying the best anti-inflammatory activity (>63% at 200 µg/mL).
AB - There is an actual need for developing materials for wound healing applications with anti-inflammatory, antioxidant, or antibacterial properties in order to improve the healing performance. In this work, we report the preparation and characterization of soft and bioactive iongel materials for patches, based on polymeric poly(vinyl alcohol) (PVA) and four ionic liquids containing the cholinium cation and different phenolic acid anions, namely cholinium salicylate ([Ch][Sal]), cholinium gallate ([Ch][Ga]), cholinium vanillate ([Ch][Van]), and cholinium caffeate ([Ch][Caff]). Within the iongels, the phenolic motif in the ionic liquids plays a dual role, acting as a PVA crosslinker and a bioactive compound. The obtained iongels are flexible, elastic, ionic conducting, and thermoreversible materials. Moreover, the iongels demonstrated high biocompatibility, non-hemolytic activity, and non-agglutination in mice blood, which are key-sought material specifications in wound healing applications. All the iongels have shown antibacterial properties, being PVA-[Ch][Sal], the one with higher inhibition halo for Escherichia Coli. The iongels also revealed high values of antioxidant activity due to the presence of the polyphenol, with the PVA-[Ch][Van] iongel having the highest activity. Finally, the iongels show a decrease in NO production in LPS-stimulated macrophages, with the PVA-[Ch][Sal] iongel displaying the best anti-inflammatory activity (>63% at 200 µg/mL).
KW - biocompatible ionic liquids
KW - iongels
KW - wound healing
UR - http://www.scopus.com/inward/record.url?scp=85149731882&partnerID=8YFLogxK
U2 - 10.3390/polym15051076
DO - 10.3390/polym15051076
M3 - Article
C2 - 36904316
AN - SCOPUS:85149731882
SN - 2073-4360
VL - 15
JO - Polymers
JF - Polymers
IS - 5
M1 - 1076
ER -