Polypharmacology of Aconitum and Delphinium sp. Diterpene alka loids

Antiarrhythmic, analgesic and anti-inflammatory effects

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Up to now, the polypharmacology of diterpene alkaloids isolated from Aconitum and Delphinium sp. has been extensively studied. From 1998 to 2014, more than 400 new diterpene alkaloids were isolated from Nature. Pharmacological researches have indicated that many diterpenoid alkaloids are the main bioactive components which have arrhythmogenic, local anesthetic, antiarrhythmic, curariform, analgesic, hypotensive, anti-inflammatory, anti-microbial, anti-tumor, spasmolytic, neurotropic and psychotropic activities. In the present review, the antiarrhythmic, analgesic and anti-inflammatory activities of diterpene alkaloids as well as the pharmacological mechanisms were summarized. Moreover, their Structure-Activity Relationship was also analyzed.

Original languageEnglish
Pages (from-to)304-310
Number of pages7
JournalMini-Reviews in Organic Chemistry
Volume14
Issue number4
DOIs
Publication statusPublished - 1 Aug 2017

Fingerprint

Aconitum
Diterpenes
Non-Steroidal Anti-Inflammatory Agents
Alkaloids
Parasympatholytics
Local Anesthetics
Analgesics
Tumors
Anti-Inflammatory Agents

Keywords

  • Aconitum
  • Analgesic activity
  • Anti-inflammatory activity
  • Antiarrhythmic activity
  • Delphinium sp.
  • Diterpene alkaloids

Cite this

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title = "Polypharmacology of Aconitum and Delphinium sp. Diterpene alka loids: Antiarrhythmic, analgesic and anti-inflammatory effects",
abstract = "Up to now, the polypharmacology of diterpene alkaloids isolated from Aconitum and Delphinium sp. has been extensively studied. From 1998 to 2014, more than 400 new diterpene alkaloids were isolated from Nature. Pharmacological researches have indicated that many diterpenoid alkaloids are the main bioactive components which have arrhythmogenic, local anesthetic, antiarrhythmic, curariform, analgesic, hypotensive, anti-inflammatory, anti-microbial, anti-tumor, spasmolytic, neurotropic and psychotropic activities. In the present review, the antiarrhythmic, analgesic and anti-inflammatory activities of diterpene alkaloids as well as the pharmacological mechanisms were summarized. Moreover, their Structure-Activity Relationship was also analyzed.",
keywords = "Aconitum, Analgesic activity, Anti-inflammatory activity, Antiarrhythmic activity, Delphinium sp., Diterpene alkaloids",
author = "Florbela Pereira",
note = "Sem PDF. Fundacao para a Ciencia e a Tecnologia (FCT/MEC) Portugal SFRH/BPD/108237/2015) Associated Laboratory for Sustainable Chemistry - Clean Processes and Technologies - LAQV - FCT/MEC (UID/QUI/50006/2013) ERDF (POCI-01-0145-FEDER-007265)",
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T1 - Polypharmacology of Aconitum and Delphinium sp. Diterpene alka loids

T2 - Antiarrhythmic, analgesic and anti-inflammatory effects

AU - Pereira, Florbela

N1 - Sem PDF. Fundacao para a Ciencia e a Tecnologia (FCT/MEC) Portugal SFRH/BPD/108237/2015) Associated Laboratory for Sustainable Chemistry - Clean Processes and Technologies - LAQV - FCT/MEC (UID/QUI/50006/2013) ERDF (POCI-01-0145-FEDER-007265)

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N2 - Up to now, the polypharmacology of diterpene alkaloids isolated from Aconitum and Delphinium sp. has been extensively studied. From 1998 to 2014, more than 400 new diterpene alkaloids were isolated from Nature. Pharmacological researches have indicated that many diterpenoid alkaloids are the main bioactive components which have arrhythmogenic, local anesthetic, antiarrhythmic, curariform, analgesic, hypotensive, anti-inflammatory, anti-microbial, anti-tumor, spasmolytic, neurotropic and psychotropic activities. In the present review, the antiarrhythmic, analgesic and anti-inflammatory activities of diterpene alkaloids as well as the pharmacological mechanisms were summarized. Moreover, their Structure-Activity Relationship was also analyzed.

AB - Up to now, the polypharmacology of diterpene alkaloids isolated from Aconitum and Delphinium sp. has been extensively studied. From 1998 to 2014, more than 400 new diterpene alkaloids were isolated from Nature. Pharmacological researches have indicated that many diterpenoid alkaloids are the main bioactive components which have arrhythmogenic, local anesthetic, antiarrhythmic, curariform, analgesic, hypotensive, anti-inflammatory, anti-microbial, anti-tumor, spasmolytic, neurotropic and psychotropic activities. In the present review, the antiarrhythmic, analgesic and anti-inflammatory activities of diterpene alkaloids as well as the pharmacological mechanisms were summarized. Moreover, their Structure-Activity Relationship was also analyzed.

KW - Aconitum

KW - Analgesic activity

KW - Anti-inflammatory activity

KW - Antiarrhythmic activity

KW - Delphinium sp.

KW - Diterpene alkaloids

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SN - 1570-193X

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