Polymeric nanoparticles: A study on the preparation variables and characterization methods

Carina I.C. Crucho, Maria Teresa Barros

Research output: Contribution to journalReview articlepeer-review

352 Citations (Scopus)


Since the emergence of Nanotechnology in the past decades, the development and design of nanomaterials has become an important field of research. An emerging component in this field is nanomedicine, wherein nanoscale materials are being developed for use as imaging agents or for drug delivery applications. Much work is currently focused in the preparation of well-defined nanomaterials in terms of size and shape. These factors play a significantly role in the nanomaterial behavior in vivo. In this context, this review focuses on the toolbox of available methods for the preparation of polymeric nanoparticles. We highlight some recent examples from the literature that demonstrate the influence of the preparation method on the physicochemical characteristics of the nanoparticles. Additionally, in the second part, the characterization methods for this type of nanoparticles are discussed.

Original languageEnglish
Pages (from-to)771-784
Number of pages14
JournalMaterials Science and Engineering C
Publication statusPublished - 1 Nov 2017


  • Drug delivery
  • Nanomedicine
  • Polymeric nanoparticles


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