Polymer micro and nanoparticles containing B(III) compounds as emissive soft materials for cargo encapsulation and temperature-dependent applications

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Polymer nanoparticles doped with fluorescent molecules are widely applied for biological assays, local temperature measurements, and other bioimaging applications, overcoming several critical drawbacks, such as dye toxicity, increased water solubility, and allowing imaging of dyes/drug delivery in water. In this work, some polymethylmethacrylate (PMMA), polyvinylpyrrolidone (PVP) and poly(styrene-butadiene-styrene) (SBS) based micro and nanoparticles with an average size of about 200 nm and encapsulating B(III) compounds have been prepared via the reprecipitation method by using tetrahydrofuran as the oil phase and water. The compounds are highly hydrophobic, but their encapsulation into a polymer matrix allows obtaining stable colloidal dispersions in water (3.39 µM) that maintain the photophysical behavior of these dyes. Although thermally activated non-radiative processes occur by increasing temperature from 25 to 80C, the colloidal suspension of the B(III) particles continues to emit greenish light (λ = 509 nm) at high temperatures. When samples are cooling back to room temperature, the emission is restored, being reversible. A probe of concept drug delivery study was conducted using coumarin 6 as a prototype of a hydrophobic drug.

Original languageEnglish
Article number3437
JournalNanomaterials
Volume11
Issue number12
DOIs
Publication statusPublished - 18 Dec 2021

Keywords

  • Drug delivery
  • Organoboranes
  • Polymer nanoparticles
  • Temperature sensors

Fingerprint

Dive into the research topics of 'Polymer micro and nanoparticles containing B(III) compounds as emissive soft materials for cargo encapsulation and temperature-dependent applications'. Together they form a unique fingerprint.

Cite this