Point Prevalence Survey on Antibiotic use in Portuguese Neonatal Intensive Care Units

Neto MT, Alexandra Almeida, Almerinda Pereira, Cristina Resende, Ermelinda Mendes, Ana Lúcia Maia, Margarida Abrantes, Margarida Cabral, Mónica Marçal, Madalena Tuna, Olga Voutsen, Susan Pissarra, Teresa Jacinto, Teresa Cezanne, Teresa Caldeira

Research output: Contribution to conferencePaper


Introduction: A point-prevalence survey (PPS) was performed in Portuguese NICUs to evaluate antibiotic prescription. Methods: Inquiry on antibiotics prescription covering seven days (October 2017, 16th to 22nd) was sent to 18
NICUs. Participation was voluntary and anonymous. Results: Participation rate was 77.8% (14/18 NICUs). Out of the 234 patients enrolled (median of gestational age and birth weight 33weeks and 1825g), 67 were under
antibiotics (28.6%) for a total of individual antibiotic prescriptions of 128 in 53 associations; 4 patients had two cycles of antibiotics during the week; 4 patients had only one antibiotic – acyclovir, meropenem, amoxicillin + clavulanic acid, vancomycin; 43 had association of two antibiotics the most frequent being ampicillin + gentamicin (n=32); 8 had 7 different combinations of three antibiotics among ampicillin, gentamicin, metronidazol, meropenem,
cefotaxime and vancomycin. In 31 out of the 67 patients with antibiotics, prescription intended to treat early-onset infection/infectious risk (47%) . Days free of antibiotics were calculated to be 1104 out of 1471 in-hospital days
(75.1%). Rate of antibiotics use was 25%. Four out of the 53 prescriptions in association may be considered as inadequate. Eleven patients had positive cultures: Coagulase negative Staphylococcus, Enterobacter cloacae, E. coli, S.aureus; Kl pn ESBL. Conclusion: Prevalence of antibiotic prescription was
low and days free of antibiotics was at a good level. As it would be expected according to the main reason to prescribe antibiotics the most common association was ampicillin and gentamicin. Four out of the 53 associations
could be subject of discussion.
Original languageEnglish
Publication statusPublished - Jun 2019
Event27th European Workshop on Neonatology - Rotterdam, Rotterdam, Netherlands
Duration: 1 Sept 20193 Sept 2019
Conference number: 27th


Workshop27th European Workshop on Neonatology


Dive into the research topics of 'Point Prevalence Survey on Antibiotic use in Portuguese Neonatal Intensive Care Units'. Together they form a unique fingerprint.

Cite this