TY - JOUR
T1 - Pneumocystis jirovecii colonization in preterm newborns with respiratory distress syndrome
AU - Szydłowicz, Magdalena
AU - Królak-Olejnik, Barbara
AU - Vargas, Sergio L
AU - Zajączkowska, Żaneta
AU - Paluszyńska, Dorota
AU - Szczygieł, Anna
AU - Matos, Olga
AU - Hendrich, Andrzej B
AU - Kicia, Marta
N1 - © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].
PY - 2022/5/16
Y1 - 2022/5/16
N2 - We describe the prevalence of Pneumocystis jirovecii in mother-infant pairs of very low birth weight newborns <32 weeks gestation. Molecular and microscopic methods were used for detection of P. jirovecii in patients' specimens. Pneumocystis DNA was detected in eight nasopharyngeal aspirates (14%) of 56 newborns and in seven oral washes (21%) of 34 mothers. Pneumocystis detection immediately after birth suggests the possibility of its transplacental transmission. Comparing to non-colonized infants, more frequent occurrence of bronchopulmonary dysplasia was seen in colonized ones (P=0.02), suggesting a potential clinical importance of this pathogen in abnormal lung development.
AB - We describe the prevalence of Pneumocystis jirovecii in mother-infant pairs of very low birth weight newborns <32 weeks gestation. Molecular and microscopic methods were used for detection of P. jirovecii in patients' specimens. Pneumocystis DNA was detected in eight nasopharyngeal aspirates (14%) of 56 newborns and in seven oral washes (21%) of 34 mothers. Pneumocystis detection immediately after birth suggests the possibility of its transplacental transmission. Comparing to non-colonized infants, more frequent occurrence of bronchopulmonary dysplasia was seen in colonized ones (P=0.02), suggesting a potential clinical importance of this pathogen in abnormal lung development.
KW - Pneumocystis jirovecii
KW - preterm infants
KW - Vertical transmission
KW - respiratory distress syndrome
KW - bronchopulmonary dysplasia
UR - http://dx.doi.org/10.1093/infdis/jiab209
U2 - 10.1093/infdis/jiab209
DO - 10.1093/infdis/jiab209
M3 - Article
C2 - 33857302
SN - 0022-1899
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
ER -