@article{f37f170d5b4c4a4ebacfaeed85c95986,
title = "Platelet transfusions in adult thrombocytopenic ICU patients: Protocol for a sub-study of the PLOT-ICU cohort",
abstract = "Introduction: Platelet transfusions are frequently used in intensive care unit (ICU) patients, but contemporary epidemiological data are sparse. We aim to present contemporary international data on the use of platelet transfusions in adult ICU patients with thrombocytopenia. Methods: This is a protocol and statistical analysis plan for a post hoc sub-study of 504 thrombocytopenic patients from the {\textquoteleft}Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU){\textquoteright}. The primary outcome will be the number of patients receiving platelet transfusion in the ICU reported according to the type of product received (apheresis-derived versus pooled whole-blood-derived transfusions). Secondary platelet transfusion outcomes will include platelet transfusion volumes; timing of platelet transfusion; approach to platelet transfusion dosing (fixed dosing versus weight-based dosing) and platelet count increments for prophylactic transfusions. Secondary clinical outcomes will include the number of patients receiving red blood cell- and plasma transfusions during ICU stay; the number of patients who bled in the ICU, the number of patients who had a new thrombosis in the ICU, and the number of patients who died. The duration of follow-up was 90 days. Baseline characteristics and secondary clinical outcomes will be stratified according to platelet transfusion status in the ICU and severity of thrombocytopenia. Data will be presented descriptively. Conclusions: The outlined study will provide detailed epidemiological data on the use of platelet transfusions in adult ICU patients with thrombocytopenia using data from the large international PLOT-ICU cohort study. The findings will inform the design of future randomised trials evaluating platelet transfusions in ICU patients.",
keywords = "critical care, intensive care unit, platelet transfusions, thrombocytopenia",
author = "Anthon, {Carl Thomas} and Fr{\'e}d{\'e}ric P{\`e}ne and Anders Perner and Elie Azoulay and Kathryn Puxty and {Van De Louw}, Andry and Sanjay Chawla and Pedro Castro and Pedro Povoa and Luis Coelho and Victoria Metaxa and Matthias Kochanek and Tobias Liebregts and Thomas Kander and Mirka Sivula and M{\o}ller, {Morten Hylander} and Lene Russell",
note = "Funding Information: This work was supported by the Research Council of Rigshospitalet (CTA, LR), the Ehrenreich's Foundation (CTA) and the Dagmar Marshalls Foundation (LR). The funders had no influence on the design, conduct, analysis or interpretation of this study. Funding Information: The Department of Intensive Care at Rigshospitalet (CTA, AP, MHM, LR) has received funding for other research projects from Sygeforsikringen {\textquoteleft}danmark{\textquoteright} and the Novo Nordisk Foundation. FP has received honoraria for consulting and lectures from Gilead and an institutional grant from Alexion Pharma. AP has received honoraria from Novartis for participation in an advisory board. EA has received research grants from MSD Avenir and Alexion and honoraria for lectures from Alexion, Sanofi and Pfizer. AVDL has received honoraria from Sanofi for participation in an advisory board. PC has received consulting fees from Sanofi, Gilead, Alexion and Janssen and honoraria for lectures from Merck Sharp & Dohme, Gilead, Alexion and Pfizer. PP has received consulting fees from Sanofi and Gilead and honoraria from Merck Sharp & Dohme, Gilead, Mundipharma and Pfizer for academic and educational work. MS has received honoraria for lectures and participating in an advisory board from CSL Behring, Alexion, AstraZeneca Rare Disease and Takeda. None of these have any relation to the current work. Publisher Copyright: {\textcopyright} 2023 Acta Anaesthesiologica Scandinavica Foundation.",
year = "2024",
month = mar,
doi = "10.1111/aas.14365",
language = "English",
journal = "Acta Anaesthesiologica Scandinavica",
issn = "0001-5172",
publisher = "Wiley",
}