Plasmodium falciparum: diversity studies of isolates from two Colombian regions with different endemicity

Montoya,  L.; A Maestre; José Carmona; D Lopes; Virgilio Estólio do Rosário; Blair, S.

doi:10.1016/s0014-4894(03)00112-7

Plasmodium falciparum: diversity studies of isolates from two Colombian regions with different endemicity

Montoya, L. , A Maestre, José Carmona, D Lopes, Virgilio Estólio do Rosário, Blair, S.

Research output: Contribution to journal › Article › peer-review

Abstract

The population structure of Plasmodium falciparum has been widely studied in diverse epidemiological contexts, but emphasis has been made in regions with high and stable transmission. In order to establish the genetic structure of P. falciparum in areas of Colombia with different degree of endemicity, we studied 100 samples from malaria patients of two different municipalities. The frequency of multiclonal infection in these areas and the correlation with the endemicity were carried out by comparison of the amplified products from polymorphic segments of MSP-1, MSP-2, and GLURP genes. We found low size polymorphism of the studied genes: 1 MSP-1 allele, 3 MSP-2 alleles, and 4 GLURP alleles. We conclude that the P. falciparum population in the regions studied is genetically homogeneous.

Original language	English
Pages (from-to)	14-19
Number of pages	6
Journal	Experimental Parasitology
Volume	Vol. 104
Issue number	n.º 1-2
DOIs	https://doi.org/10.1016/s0014-4894(03)00112-7
Publication status	Published - May 2003

Keywords

Plasmodium falciparum
MSP-1
MSP-2
GLURP
Genotyping
Endemicity
Colombia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/s0014-4894(03)00112-7

Cite this

@article{3d0568dca59d491a8ff36ddb4ad5f7a4,

title = "Plasmodium falciparum: diversity studies of isolates from two Colombian regions with different endemicity",

abstract = "The population structure of Plasmodium falciparum has been widely studied in diverse epidemiological contexts, but emphasis has been made in regions with high and stable transmission. In order to establish the genetic structure of P. falciparum in areas of Colombia with different degree of endemicity, we studied 100 samples from malaria patients of two different municipalities. The frequency of multiclonal infection in these areas and the correlation with the endemicity were carried out by comparison of the amplified products from polymorphic segments of MSP-1, MSP-2, and GLURP genes. We found low size polymorphism of the studied genes: 1 MSP-1 allele, 3 MSP-2 alleles, and 4 GLURP alleles. We conclude that the P. falciparum population in the regions studied is genetically homogeneous.",

keywords = "Plasmodium falciparum, MSP-1, MSP-2, GLURP, Genotyping, Endemicity, Colombia",

author = "Montoya, L. and A Maestre and Jos{\'e} Carmona and D Lopes and Ros{\'a}rio, {Virgilio Est{\'o}lio do} and Blair, S.",

year = "2003",

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doi = "10.1016/s0014-4894(03)00112-7",

language = "English",

volume = "Vol. 104",

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TY - JOUR

T1 - Plasmodium falciparum

T2 - diversity studies of isolates from two Colombian regions with different endemicity

AU - L. , Montoya,

AU - Maestre, A

AU - Carmona, José

AU - Lopes, D

AU - Rosário, Virgilio Estólio do

AU - S., Blair,

PY - 2003/5

Y1 - 2003/5

N2 - The population structure of Plasmodium falciparum has been widely studied in diverse epidemiological contexts, but emphasis has been made in regions with high and stable transmission. In order to establish the genetic structure of P. falciparum in areas of Colombia with different degree of endemicity, we studied 100 samples from malaria patients of two different municipalities. The frequency of multiclonal infection in these areas and the correlation with the endemicity were carried out by comparison of the amplified products from polymorphic segments of MSP-1, MSP-2, and GLURP genes. We found low size polymorphism of the studied genes: 1 MSP-1 allele, 3 MSP-2 alleles, and 4 GLURP alleles. We conclude that the P. falciparum population in the regions studied is genetically homogeneous.

AB - The population structure of Plasmodium falciparum has been widely studied in diverse epidemiological contexts, but emphasis has been made in regions with high and stable transmission. In order to establish the genetic structure of P. falciparum in areas of Colombia with different degree of endemicity, we studied 100 samples from malaria patients of two different municipalities. The frequency of multiclonal infection in these areas and the correlation with the endemicity were carried out by comparison of the amplified products from polymorphic segments of MSP-1, MSP-2, and GLURP genes. We found low size polymorphism of the studied genes: 1 MSP-1 allele, 3 MSP-2 alleles, and 4 GLURP alleles. We conclude that the P. falciparum population in the regions studied is genetically homogeneous.

KW - Plasmodium falciparum

KW - MSP-1

KW - MSP-2

KW - GLURP

KW - Genotyping

KW - Endemicity

KW - Colombia

UR - https://www.sciencedirect.com/science/article/abs/pii/S0014489403001127?via%3Dihub#!

U2 - 10.1016/s0014-4894(03)00112-7

DO - 10.1016/s0014-4894(03)00112-7

M3 - Article

C2 - 12932754

SN - 0014-4894

VL - Vol. 104

SP - 14

EP - 19

JO - Experimental Parasitology

JF - Experimental Parasitology

IS - n.º 1-2

ER -

Plasmodium falciparum: diversity studies of isolates from two Colombian regions with different endemicity

Abstract

Keywords

UN SDGs

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