Plasmodium chabaudi: efficacy of artemisinin + curcumin combination treatment on a clone selected for artemisinin resistance in mice

Axel Martinelli, Louise A Rodrigues, Pedro Cravo

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Recent studies have proposed curcumin as a potential partner for artemisinin in artemisinin combination therapies to treat malaria infections. The efficacy of curcumin alone and in combination with artemisinin was evaluated on a clone of Plasmodium chabaudi selected for artemisinin resistance in vivo. The addition of piperine as an enhancer of curcumin activity was also tested. Results indicated that curcumin, both alone and in combination with piperine had only a modest antimalarial effect and was not able to reverse the artemisinin-resistant phenotype or significantly affect growth of the tested clone when used in combination with artemisinin. This is in contrast with previous in vivo work and calls for further experimental evaluation of the antimalarial potential of curcumin.

Original languageEnglish
Pages (from-to)304-307
Number of pages4
JournalExperimental Parasitology
Volume119
Issue number2
DOIs
Publication statusPublished - Jun 2008

Keywords

  • Administration, Oral
  • Alkaloids
  • Animals
  • Anti-Infective Agents
  • Artemisinins
  • Benzodioxoles
  • Biological Availability
  • Curcumin
  • Drug Resistance
  • Drug Therapy, Combination
  • Malaria
  • Male
  • Mice
  • Parasitemia
  • Piperidines
  • Plasmodium chabaudi
  • Polyunsaturated Alkamides
  • Journal Article
  • Research Support, Non-U.S. Gov't

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