TY - CONF
T1 - Plaque vulnerability phenotype in patients with coronary artery disease: An intravascular ultrasound radiofrequency analysis
T2 - 1st International Congress on Cardiovascular Technologies, CARDIOTECHNIX 2013
AU - Pinheiro, T.
AU - Ramos, C.
AU - Napoleão, P.
AU - Mendonça, C.
AU - Fondinho, C.
AU - Selas, M.
AU - Mota Carmo, M.
AU - Cruz Ferreira, R.
AU - Institute for Systems and Technologies of; Information, Control and Communication (INSTICC); MedinRes - Medical Information and Research
PY - 2013
Y1 - 2013
N2 - The relationship between plaque morphology and clinical presentation was examined. Lumen dimensions, atheroma morphology and composition were assessed by virtual histology intravascular ultrasound (VH-IVUS) in 1757 frames of coronary segments of interest of 17 patients with acute and chronic coronary artery disease, i.e., ST-elevation (STEMI) and non-ST-elevation (NSTEMI) myocardial infarction, unstable angina (UA) and stable angina (SA). Large plaque areas with distended elastic lamina (EEL), rich in fibrotic (FB) and fibro-fatty (FF) tissues associated with STEMI and UA. Variants of this phenotype consisting of large calcium deposits and reduced lumen area were prevalent in NSTEMI patients. SA patients consistently showed plaques with small areas, marked constrictive growth and low FF content. IVUS-derived plaque measures provided phenotypes of vulnerability and rupture that may help improving risk stratification of both symptomatic and asymptomatic patients.
AB - The relationship between plaque morphology and clinical presentation was examined. Lumen dimensions, atheroma morphology and composition were assessed by virtual histology intravascular ultrasound (VH-IVUS) in 1757 frames of coronary segments of interest of 17 patients with acute and chronic coronary artery disease, i.e., ST-elevation (STEMI) and non-ST-elevation (NSTEMI) myocardial infarction, unstable angina (UA) and stable angina (SA). Large plaque areas with distended elastic lamina (EEL), rich in fibrotic (FB) and fibro-fatty (FF) tissues associated with STEMI and UA. Variants of this phenotype consisting of large calcium deposits and reduced lumen area were prevalent in NSTEMI patients. SA patients consistently showed plaques with small areas, marked constrictive growth and low FF content. IVUS-derived plaque measures provided phenotypes of vulnerability and rupture that may help improving risk stratification of both symptomatic and asymptomatic patients.
KW - Atherosclerosis
KW - Coronary Artery Disease
KW - Vulnerable Plaque Phenotype
KW - Asymptomatic patients
KW - Clinical presentations
KW - Coronary artery disease
KW - Intravascular ultrasound
KW - Morphology and composition
KW - Myocardial Infarction
KW - Vulnerable plaques
KW - Histology
KW - Risk assessment
KW - Ultrasonics
KW - Diseases
M3 - Other
SP - 84
EP - 89
ER -