Plaque vulnerability phenotype in patients with coronary artery disease: An intravascular ultrasound radiofrequency analysis: 1st International Congress on Cardiovascular Technologies, CARDIOTECHNIX 2013

T. Pinheiro, C. Ramos, P. Napoleão, C. Mendonça, C. Fondinho, M. Selas, M. Mota Carmo, R. Cruz Ferreira, Control and Communication (INSTICC); MedinRes - Medical Information and Research Institute for Systems and Technologies of; Information

Research output: Contribution to conferenceOther

Abstract

The relationship between plaque morphology and clinical presentation was examined. Lumen dimensions, atheroma morphology and composition were assessed by virtual histology intravascular ultrasound (VH-IVUS) in 1757 frames of coronary segments of interest of 17 patients with acute and chronic coronary artery disease, i.e., ST-elevation (STEMI) and non-ST-elevation (NSTEMI) myocardial infarction, unstable angina (UA) and stable angina (SA). Large plaque areas with distended elastic lamina (EEL), rich in fibrotic (FB) and fibro-fatty (FF) tissues associated with STEMI and UA. Variants of this phenotype consisting of large calcium deposits and reduced lumen area were prevalent in NSTEMI patients. SA patients consistently showed plaques with small areas, marked constrictive growth and low FF content. IVUS-derived plaque measures provided phenotypes of vulnerability and rupture that may help improving risk stratification of both symptomatic and asymptomatic patients.
Original languageEnglish
Pages84-89
Number of pages6
Publication statusPublished - 2013

Keywords

  • Atherosclerosis
  • Coronary Artery Disease
  • Vulnerable Plaque Phenotype
  • Asymptomatic patients
  • Clinical presentations
  • Coronary artery disease
  • Intravascular ultrasound
  • Morphology and composition
  • Myocardial Infarction
  • Vulnerable plaques
  • Histology
  • Risk assessment
  • Ultrasonics
  • Diseases

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    Pinheiro, T., Ramos, C., Napoleão, P., Mendonça, C., Fondinho, C., Selas, M., ... Institute for Systems and Technologies of; Information, C. A. C. INSTICC. M. . M. I. A. R. (2013). Plaque vulnerability phenotype in patients with coronary artery disease: An intravascular ultrasound radiofrequency analysis: 1st International Congress on Cardiovascular Technologies, CARDIOTECHNIX 2013. 84-89.