Plaque vulnerability phenotype in patients with coronary artery disease: An intravascular ultrasound radiofrequency analysis

1st International Congress on Cardiovascular Technologies, CARDIOTECHNIX 2013

T. Pinheiro, C. Ramos, P. Napoleão, C. Mendonça, C. Fondinho, M. Selas, M. Mota Carmo, R. Cruz Ferreira, Control and Communication (INSTICC); MedinRes - Medical Information and Research Institute for Systems and Technologies of; Information

Research output: Contribution to conferenceOther

Abstract

The relationship between plaque morphology and clinical presentation was examined. Lumen dimensions, atheroma morphology and composition were assessed by virtual histology intravascular ultrasound (VH-IVUS) in 1757 frames of coronary segments of interest of 17 patients with acute and chronic coronary artery disease, i.e., ST-elevation (STEMI) and non-ST-elevation (NSTEMI) myocardial infarction, unstable angina (UA) and stable angina (SA). Large plaque areas with distended elastic lamina (EEL), rich in fibrotic (FB) and fibro-fatty (FF) tissues associated with STEMI and UA. Variants of this phenotype consisting of large calcium deposits and reduced lumen area were prevalent in NSTEMI patients. SA patients consistently showed plaques with small areas, marked constrictive growth and low FF content. IVUS-derived plaque measures provided phenotypes of vulnerability and rupture that may help improving risk stratification of both symptomatic and asymptomatic patients.
Original languageEnglish
Pages84-89
Number of pages6
Publication statusPublished - 2013

Fingerprint

Coronary Artery Disease
Technology
Phenotype
Stable Angina
Unstable Angina
Atherosclerotic Plaques
Adipose Tissue
Rupture
Histology
Calcium
Growth
Non-ST Elevated Myocardial Infarction
ST Elevation Myocardial Infarction

Keywords

  • Atherosclerosis
  • Coronary Artery Disease
  • Vulnerable Plaque Phenotype
  • Asymptomatic patients
  • Clinical presentations
  • Coronary artery disease
  • Intravascular ultrasound
  • Morphology and composition
  • Myocardial Infarction
  • Vulnerable plaques
  • Histology
  • Risk assessment
  • Ultrasonics
  • Diseases

Cite this

Pinheiro, T., Ramos, C., Napoleão, P., Mendonça, C., Fondinho, C., Selas, M., ... Institute for Systems and Technologies of; Information, C. A. C. INSTICC. M. . M. I. A. R. (2013). Plaque vulnerability phenotype in patients with coronary artery disease: An intravascular ultrasound radiofrequency analysis: 1st International Congress on Cardiovascular Technologies, CARDIOTECHNIX 2013. 84-89.
Pinheiro, T. ; Ramos, C. ; Napoleão, P. ; Mendonça, C. ; Fondinho, C. ; Selas, M. ; Mota Carmo, M. ; Cruz Ferreira, R. ; Institute for Systems and Technologies of; Information, Control and Communication (INSTICC); MedinRes - Medical Information and Research. / Plaque vulnerability phenotype in patients with coronary artery disease: An intravascular ultrasound radiofrequency analysis : 1st International Congress on Cardiovascular Technologies, CARDIOTECHNIX 2013. 6 p.
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title = "Plaque vulnerability phenotype in patients with coronary artery disease: An intravascular ultrasound radiofrequency analysis: 1st International Congress on Cardiovascular Technologies, CARDIOTECHNIX 2013",
abstract = "The relationship between plaque morphology and clinical presentation was examined. Lumen dimensions, atheroma morphology and composition were assessed by virtual histology intravascular ultrasound (VH-IVUS) in 1757 frames of coronary segments of interest of 17 patients with acute and chronic coronary artery disease, i.e., ST-elevation (STEMI) and non-ST-elevation (NSTEMI) myocardial infarction, unstable angina (UA) and stable angina (SA). Large plaque areas with distended elastic lamina (EEL), rich in fibrotic (FB) and fibro-fatty (FF) tissues associated with STEMI and UA. Variants of this phenotype consisting of large calcium deposits and reduced lumen area were prevalent in NSTEMI patients. SA patients consistently showed plaques with small areas, marked constrictive growth and low FF content. IVUS-derived plaque measures provided phenotypes of vulnerability and rupture that may help improving risk stratification of both symptomatic and asymptomatic patients.",
keywords = "Atherosclerosis, Coronary Artery Disease, Vulnerable Plaque Phenotype, Asymptomatic patients, Clinical presentations, Coronary artery disease, Intravascular ultrasound, Morphology and composition, Myocardial Infarction, Vulnerable plaques, Histology, Risk assessment, Ultrasonics, Diseases",
author = "T. Pinheiro and C. Ramos and P. Napole{\~a}o and C. Mendon{\cc}a and C. Fondinho and M. Selas and {Mota Carmo}, M. and {Cruz Ferreira}, R. and {Institute for Systems and Technologies of; Information}, {Control and Communication (INSTICC); MedinRes - Medical Information and Research}",
year = "2013",
language = "English",
pages = "84--89",

}

Pinheiro, T, Ramos, C, Napoleão, P, Mendonça, C, Fondinho, C, Selas, M, Mota Carmo, M, Cruz Ferreira, R & Institute for Systems and Technologies of; Information, CACINSTICCMMIAR 2013, 'Plaque vulnerability phenotype in patients with coronary artery disease: An intravascular ultrasound radiofrequency analysis: 1st International Congress on Cardiovascular Technologies, CARDIOTECHNIX 2013' pp. 84-89.

Plaque vulnerability phenotype in patients with coronary artery disease: An intravascular ultrasound radiofrequency analysis : 1st International Congress on Cardiovascular Technologies, CARDIOTECHNIX 2013. / Pinheiro, T.; Ramos, C.; Napoleão, P.; Mendonça, C.; Fondinho, C.; Selas, M.; Mota Carmo, M.; Cruz Ferreira, R.; Institute for Systems and Technologies of; Information, Control and Communication (INSTICC); MedinRes - Medical Information and Research.

2013. 84-89.

Research output: Contribution to conferenceOther

TY - CONF

T1 - Plaque vulnerability phenotype in patients with coronary artery disease: An intravascular ultrasound radiofrequency analysis

T2 - 1st International Congress on Cardiovascular Technologies, CARDIOTECHNIX 2013

AU - Pinheiro, T.

AU - Ramos, C.

AU - Napoleão, P.

AU - Mendonça, C.

AU - Fondinho, C.

AU - Selas, M.

AU - Mota Carmo, M.

AU - Cruz Ferreira, R.

AU - Institute for Systems and Technologies of; Information, Control and Communication (INSTICC); MedinRes - Medical Information and Research

PY - 2013

Y1 - 2013

N2 - The relationship between plaque morphology and clinical presentation was examined. Lumen dimensions, atheroma morphology and composition were assessed by virtual histology intravascular ultrasound (VH-IVUS) in 1757 frames of coronary segments of interest of 17 patients with acute and chronic coronary artery disease, i.e., ST-elevation (STEMI) and non-ST-elevation (NSTEMI) myocardial infarction, unstable angina (UA) and stable angina (SA). Large plaque areas with distended elastic lamina (EEL), rich in fibrotic (FB) and fibro-fatty (FF) tissues associated with STEMI and UA. Variants of this phenotype consisting of large calcium deposits and reduced lumen area were prevalent in NSTEMI patients. SA patients consistently showed plaques with small areas, marked constrictive growth and low FF content. IVUS-derived plaque measures provided phenotypes of vulnerability and rupture that may help improving risk stratification of both symptomatic and asymptomatic patients.

AB - The relationship between plaque morphology and clinical presentation was examined. Lumen dimensions, atheroma morphology and composition were assessed by virtual histology intravascular ultrasound (VH-IVUS) in 1757 frames of coronary segments of interest of 17 patients with acute and chronic coronary artery disease, i.e., ST-elevation (STEMI) and non-ST-elevation (NSTEMI) myocardial infarction, unstable angina (UA) and stable angina (SA). Large plaque areas with distended elastic lamina (EEL), rich in fibrotic (FB) and fibro-fatty (FF) tissues associated with STEMI and UA. Variants of this phenotype consisting of large calcium deposits and reduced lumen area were prevalent in NSTEMI patients. SA patients consistently showed plaques with small areas, marked constrictive growth and low FF content. IVUS-derived plaque measures provided phenotypes of vulnerability and rupture that may help improving risk stratification of both symptomatic and asymptomatic patients.

KW - Atherosclerosis

KW - Coronary Artery Disease

KW - Vulnerable Plaque Phenotype

KW - Asymptomatic patients

KW - Clinical presentations

KW - Coronary artery disease

KW - Intravascular ultrasound

KW - Morphology and composition

KW - Myocardial Infarction

KW - Vulnerable plaques

KW - Histology

KW - Risk assessment

KW - Ultrasonics

KW - Diseases

M3 - Other

SP - 84

EP - 89

ER -