Plants and their extracts have been used traditionally against different pathologies, and in some poor regions they are the only therapeutic source for treatments and the presence of specific active secondary metabolites can be account for amelioration of clinical status of suffering individual. A series of ethnopharmacological surveys conducted in Brazil recorded the traditional use of plants against different pathologies and interestingly, some of them presented antileishmanial activity in vitro and in vivo, possibly due to their immunostimulatory, healing and microbicidal properties. Of note, Leishmania parasites can alter patient's immunological status, leading to the development of extensive skin and/or visceral alterations. Therefore, the extracts or secondary metabolites presented in plants that might be capable of modifying these pathological conditions can be attractive candidates in the development of new chemotherapeuticals against leishmaniosis.
|Journal||Current Clinical Pharmacology|
|Publication status||Published - 2014|
Passero , LFD., Laurenti , MD., Simões, G. M. S. G. O., Soares Campos , BL., Sartorelli, P., & Lago , JH. (2014). Plants Used in Traditional Medicine: Extracts and Secondary Metabolites Exhibiting Antileishmanial Activity. Current Clinical Pharmacology, 9(3), 187-204.