Piperacillin-tazobactam anaphylaxis

a rare cause of occupational disease

Research output: Contribution to journalArticle

Abstract

Summary: Piperacillin is a beta-lactam antibiotic of penicillin family. Some penicillins were report-ed as occupational diseases cause, but piperacillin anaphylaxis with occupational sensi-tization is rare. We describe the case of a female nurse with recurrent anaphylaxis in last few months without apparent cause, only in work environment. Latex allergy was excluded after negative latex glove provocation. Later during diagnostic workup, the patient reported a similar reaction minutes after piperacillin preparation. She denied any previous antibiotic therapeutic exposure. Skin prick tests (SPT) to beta-lactams were positive to piperacillin, penicillin G and major and minor determinants. SPT to cefuroxime was negative but intradermic test was positive. The patient has indication for beta-lactams eviction and for adrenaline auto-injector kit. No further reactions occurred after patient's transfer to another department with minimum possible exposure. Allergic risk prevention is essential and must be rapidly implemented to avoid incapacitating occupational diseases development.

Original languageEnglish
Pages (from-to)89-91
Number of pages3
JournalEuropean annals of allergy and clinical immunology
Volume50
Issue number2
Early online date20 Nov 2017
DOIs
Publication statusPublished - 1 Mar 2018

Fingerprint

Piperacillin
Occupational Diseases
Anaphylaxis
beta-Lactams
Skin Tests
Penicillins
Latex Hypersensitivity
Patient Transfer
Cefuroxime
Penicillin G
Latex
Epinephrine
Nurses
Anti-Bacterial Agents
tazobactam drug combination piperacillin
Therapeutics

Keywords

  • anaphylaxis
  • beta-lactams
  • drug hypersensitivity
  • occupational diseases
  • piperacillin

Cite this

@article{b71da03fd13f4a898c6850200f121a36,
title = "Piperacillin-tazobactam anaphylaxis: a rare cause of occupational disease",
abstract = "Summary: Piperacillin is a beta-lactam antibiotic of penicillin family. Some penicillins were report-ed as occupational diseases cause, but piperacillin anaphylaxis with occupational sensi-tization is rare. We describe the case of a female nurse with recurrent anaphylaxis in last few months without apparent cause, only in work environment. Latex allergy was excluded after negative latex glove provocation. Later during diagnostic workup, the patient reported a similar reaction minutes after piperacillin preparation. She denied any previous antibiotic therapeutic exposure. Skin prick tests (SPT) to beta-lactams were positive to piperacillin, penicillin G and major and minor determinants. SPT to cefuroxime was negative but intradermic test was positive. The patient has indication for beta-lactams eviction and for adrenaline auto-injector kit. No further reactions occurred after patient's transfer to another department with minimum possible exposure. Allergic risk prevention is essential and must be rapidly implemented to avoid incapacitating occupational diseases development.",
keywords = "anaphylaxis, beta-lactams, drug hypersensitivity, occupational diseases, piperacillin",
author = "J Gaspar-Marques and E Finelli and Martins, {P C} and S Prates and P Leiria-Pinto",
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Piperacillin-tazobactam anaphylaxis : a rare cause of occupational disease. / Gaspar-Marques, J; Finelli, E; Martins, P C; Prates, S; Leiria-Pinto, P.

In: European annals of allergy and clinical immunology, Vol. 50, No. 2, 01.03.2018, p. 89-91.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Piperacillin-tazobactam anaphylaxis

T2 - a rare cause of occupational disease

AU - Gaspar-Marques, J

AU - Finelli, E

AU - Martins, P C

AU - Prates, S

AU - Leiria-Pinto, P

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Summary: Piperacillin is a beta-lactam antibiotic of penicillin family. Some penicillins were report-ed as occupational diseases cause, but piperacillin anaphylaxis with occupational sensi-tization is rare. We describe the case of a female nurse with recurrent anaphylaxis in last few months without apparent cause, only in work environment. Latex allergy was excluded after negative latex glove provocation. Later during diagnostic workup, the patient reported a similar reaction minutes after piperacillin preparation. She denied any previous antibiotic therapeutic exposure. Skin prick tests (SPT) to beta-lactams were positive to piperacillin, penicillin G and major and minor determinants. SPT to cefuroxime was negative but intradermic test was positive. The patient has indication for beta-lactams eviction and for adrenaline auto-injector kit. No further reactions occurred after patient's transfer to another department with minimum possible exposure. Allergic risk prevention is essential and must be rapidly implemented to avoid incapacitating occupational diseases development.

AB - Summary: Piperacillin is a beta-lactam antibiotic of penicillin family. Some penicillins were report-ed as occupational diseases cause, but piperacillin anaphylaxis with occupational sensi-tization is rare. We describe the case of a female nurse with recurrent anaphylaxis in last few months without apparent cause, only in work environment. Latex allergy was excluded after negative latex glove provocation. Later during diagnostic workup, the patient reported a similar reaction minutes after piperacillin preparation. She denied any previous antibiotic therapeutic exposure. Skin prick tests (SPT) to beta-lactams were positive to piperacillin, penicillin G and major and minor determinants. SPT to cefuroxime was negative but intradermic test was positive. The patient has indication for beta-lactams eviction and for adrenaline auto-injector kit. No further reactions occurred after patient's transfer to another department with minimum possible exposure. Allergic risk prevention is essential and must be rapidly implemented to avoid incapacitating occupational diseases development.

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