Pigmented Full-Thickness Human Skin Model Based on a Fibroblast-Derived Matrix for Long-Term Studies

Patrícia Zoio, Sara Ventura, Mafalda Leite, Abel Oliva

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

The developed fully human full-thickness skin model has the potential to reduce the dependence on animal models for long-term studies of skin diseases and safety and efficacy assessment of novel drugs. Its longevity and robustness allow the experimental testing phase to be lengthened. The presence of active melanocytes at the dermal-epidermal junction makes this model the ideal platform to study skin pigmentation disorders.

Original languageEnglish
Pages (from-to)433-443
Number of pages11
JournalTissue Engineering - Part C: Methods
Volume27
Issue number7
DOIs
Publication statusPublished - Jul 2021

Keywords

  • fibroblast-derived matrix
  • full thickness
  • fully human
  • skin
  • tissue engineering
  • transepithelial electrical resistance

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