TY - JOUR
T1 - Piezoelectric biomaterials with embedded ionic liquids for improved orthopedic interfaces through osseointegration and antibacterial dual characteristics
AU - Carvalho, E. O.
AU - Marques-Almeida, T.
AU - Cruz, B. D. D.
AU - Correia, D. M.
AU - Esperança, J. M. S. S.
AU - Irastorza, I.
AU - Silvan, U.
AU - Fernandes, M. M.
AU - Lanceros-Mendez, S.
AU - Ribeiro, C.
N1 - Funding Information:
info:eu-repo/grantAgreement/FCT/Concurso para Atribuição do Estatuto e Financiamento de Laboratórios Associados (LA)/LA%2FP%2F0008%2F2020/PT#
info:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Programático/UIDP%2F50006%2F2020/PT#
info:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Base/UIDB%2F50006%2F2020/PT#
info:eu-repo/grantAgreement/FCT/3599-PPCDT/2022.02697.PTDC/PT#
info:eu-repo/grantAgreement/FCT/3599-PPCDT/2022.05932.PTDC/PT#
info:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F145455%2F2019/PT#
info:eu-repo/grantAgreement/FCT/POR_NORTE/2022.13287.BD/PT#
info:eu-repo/grantAgreement/FCT/CEEC INST 2ed/CEECINST%2F00018%2F2021%2FCP2806%2FCT0001/PT#
Programa Operacional Competitividade e Internacionalização (POCI):
strategic funding UID/FIS/04650/2020, UID/QUI/00686/2020.
This study forms part of the Advanced Materials program and was supported by MCIN with funding from the European Union NextGenerationEU (PRTR-C17\u00B7I1) and by the Basque Government under the IKUR program. The authors also acknowledge funding by the Department of Education of the Basque Government (PIBA program) Grant number 2022333047 and POS_2023_1_0049 , from the Basque Government Industry Department under the ELKARTEK program, and by the Spanish Ministry of Science and Innovation (Grant number PID2022-138572OB-C42 ).
© 2024 The Authors. Published by Elsevier B.V.
PY - 2024/11
Y1 - 2024/11
N2 - Orthopedic implant failures, primarily attributed to aseptic loosening and implant site infections, pose significant challenges to patient recovery and lead to revision surgeries. Combining piezoelectric materials with ionic liquids as interfaces for orthopedic implants presents an innovative approach to addressing both issues simultaneously. In this study, films of poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) incorporated with 1-ethyl-3-methylimidazolium hydrogen sulfate ([Emim][HSO4]) ionic liquid were developed. These films exhibited strong antibacterial properties, effectively reducing biofilm formation, thereby addressing implant-related infections. Furthermore, stem cell-based differentiation assays exposed the potential of the composite materials to induce osteogenesis. Interestingly, our findings also revealed the upregulation of calcium channel expression as a result of electromechanical stimulation, pointing to a mechanistic basis for the observed biological effects. This work highlights the potential of piezoelectric materials with ionic liquids to improve the longevity and biocompatibility of orthopedic implants. Offering dual-functionality for infection prevention and bone integration, these advancements hold significant potential for advancing orthopedic implant technologies and improving patient outcomes.
AB - Orthopedic implant failures, primarily attributed to aseptic loosening and implant site infections, pose significant challenges to patient recovery and lead to revision surgeries. Combining piezoelectric materials with ionic liquids as interfaces for orthopedic implants presents an innovative approach to addressing both issues simultaneously. In this study, films of poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) incorporated with 1-ethyl-3-methylimidazolium hydrogen sulfate ([Emim][HSO4]) ionic liquid were developed. These films exhibited strong antibacterial properties, effectively reducing biofilm formation, thereby addressing implant-related infections. Furthermore, stem cell-based differentiation assays exposed the potential of the composite materials to induce osteogenesis. Interestingly, our findings also revealed the upregulation of calcium channel expression as a result of electromechanical stimulation, pointing to a mechanistic basis for the observed biological effects. This work highlights the potential of piezoelectric materials with ionic liquids to improve the longevity and biocompatibility of orthopedic implants. Offering dual-functionality for infection prevention and bone integration, these advancements hold significant potential for advancing orthopedic implant technologies and improving patient outcomes.
KW - Antimicrobial
KW - Bone osseointegration
KW - Ionic liquids
KW - Piezoelectric biomaterials
UR - https://www.scopus.com/pages/publications/85200267771
U2 - 10.1016/j.bioadv.2024.213970
DO - 10.1016/j.bioadv.2024.213970
M3 - Article
C2 - 39106539
AN - SCOPUS:85200267771
SN - 2772-9508
VL - 164
JO - Biomaterials advances
JF - Biomaterials advances
M1 - 213970
ER -