Photoresponsive Binding Dynamics in High-Affinity Cucurbit[8]uril-Dithienylethene Host-Guest Complexes

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3 Citations (Scopus)

Abstract

The use of external stimuli to control the binding kinetics in supramolecular systems is of critical importance for the development of advanced molecular machines and devices. In this work, a study focused on the kinetics of a water-soluble host-guest system based on cucurbit[8]uril and two dithienylethene (DTE) photoswitches is reported. It is shown that for the DTE guest comprising two anionic sulfonate side arms appended to pyridinium moieties, the formation/dissociation of the pseudorotaxane structures is slowed down by more than 100000-fold with respect to its bipyridinium analogue. The decrease in ingression rate leads to the emergence of a competitive metastable product with the open DTE isomer that has an important influence in the overall binding kinetics. Moreover, the host-guest dissociation kinetics is demonstrated to be approximately 100-fold slower for the closed DTE isomer (t1/2=107 h vs. t1/2=1.2 h for the open isomer) allowing control over the dissociation rate with light.

Original languageEnglish
Pages (from-to)9550-9555
JournalChemistry - A European Journal
Volume27
Issue number37
DOIs
Publication statusPublished - 2 Jul 2021

Keywords

  • diarylethenes
  • inclusion complexes
  • kinetics
  • photochemistry
  • supramolecular chemistry

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