Pheochromocytoma: clinical review based on a rare case in adolescence

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5 Citations (Scopus)

Abstract

Pheochromocytomas are rare tumours originating in chromaffin cells, representing 0.1-1% of all secondary hypertension (HT) cases. The majority are benign and unilateral, characterised by the production of catecholamines and other neuropeptides. Mainly located in the adrenal gland, they are more frequent between the 3rd and 5th decades of life; however, 10-25% can be associated with genetic familial syndromes (multiple endocrine neoplasia type 2 (MEN 2), type 1 neurofibromatosis and Von-Hippel-Landau disease in younger ages. The authors present a rare case of secondary HT due to a pheochromocytoma in a 15-year-old patient, whose metanephrine assay confirmed the diagnosis, and abdominal ultrasound and CT localised the tumour in the adrenal gland. HT was controlled with α and β blockers, with posterior retroperitoneal laparoscopic surgical intervention and subsequent resolution of HT. Age and concomitant hyperparathyroidism compelled genetic testing for the exclusion of MEN 2, which was negative.

Original languageEnglish
JournalBMJ case reports
Volume2015
DOIs
Publication statusPublished - 4 Aug 2015

Keywords

  • Adolescent
  • Adrenal Gland Neoplasms
  • Adrenal Glands
  • Adrenergic Antagonists
  • Blood Pressure
  • Chromaffin Cells
  • Female
  • Humans
  • Hypertension
  • Metanephrine
  • Multiple Endocrine Neoplasia Type 2a
  • Pheochromocytoma
  • Case Reports
  • Journal Article

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