TY - JOUR
T1 - Phenothiazines
T2 - potential alternatives for the management of antibiotic resistant infections of tuberculosis and malaria in developing countries
AU - Amaral, L
AU - Viveiros, M
AU - Kristiansen, Jette E.
PY - 2001/12/21
Y1 - 2001/12/21
N2 - The in vitro and in vivo activity of phenothiazines against antibiotic Susceptible and antibiotic resistant Mycobacterium tuberculosis and malaria-causing Plasmodia is reviewed. Given the facts that Pulmonary tuberculosis and malaria are the major causes of death in developing Countries, that both of these infections continue to escalate in their resistance to antibiotics, that the cost for the management of these infections is beyond that afforded by most developing nations, and lastly, that new and effective agents are not forthcoming from the pharmaceutical industry, the scientific rationale for the potential use of select phenothiazines for the management of these infections is presented.
AB - The in vitro and in vivo activity of phenothiazines against antibiotic Susceptible and antibiotic resistant Mycobacterium tuberculosis and malaria-causing Plasmodia is reviewed. Given the facts that Pulmonary tuberculosis and malaria are the major causes of death in developing Countries, that both of these infections continue to escalate in their resistance to antibiotics, that the cost for the management of these infections is beyond that afforded by most developing nations, and lastly, that new and effective agents are not forthcoming from the pharmaceutical industry, the scientific rationale for the potential use of select phenothiazines for the management of these infections is presented.
KW - Phenothiazines
KW - Antimicrobial activity
KW - Tuberculosis
KW - Malaria
KW - PLASMODIUM-FALCIPARUM
KW - MYCOBACTERIUM-TUBERCULOSIS
KW - METHYLENE-BLUE
KW - IN-VITRO
KW - POLYMORPHONUCLEAR LEUKOCYTES
KW - BIOLOGICAL MACROMOLECULES
KW - CHLOROQUINE RESISTANCE
KW - ANTILEISHMANIAL DRUGS
KW - STAPHYLOCOCCUS-AUREUS
KW - IRREVERSIBLE BINDING
UR - http://www.scopus.com/inward/record.url?scp=0035657318&partnerID=8YFLogxK
UR - https://onlinelibrary.wiley.com/doi/full/10.1046/j.1365-3156.2001.00804.x?sid=nlm%3Apubmed
U2 - 10.1046/j.1365-3156.2001.00804.x
DO - 10.1046/j.1365-3156.2001.00804.x
M3 - Article
C2 - 11737839
SN - 1360-2276
VL - Vol. 6
SP - 1016
EP - 1022
JO - Tropical Medicine & International Health
JF - Tropical Medicine & International Health
IS - n.º 12
ER -