Phenothiazines: potential alternatives for the management of antibiotic resistant infections of tuberculosis and malaria in developing countries

L Amaral, M Viveiros, Jette E. Kristiansen

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67 Citations (Scopus)

Abstract

The in vitro and in vivo activity of phenothiazines against antibiotic Susceptible and antibiotic resistant Mycobacterium tuberculosis and malaria-causing Plasmodia is reviewed. Given the facts that Pulmonary tuberculosis and malaria are the major causes of death in developing Countries, that both of these infections continue to escalate in their resistance to antibiotics, that the cost for the management of these infections is beyond that afforded by most developing nations, and lastly, that new and effective agents are not forthcoming from the pharmaceutical industry, the scientific rationale for the potential use of select phenothiazines for the management of these infections is presented.

Original languageEnglish
Pages (from-to)1016-1022
Number of pages7
JournalTropical medicine & international health : TM & IH
VolumeVol. 6
Issue numbern.º 12
DOIs
Publication statusPublished - 21 Dec 2001

Keywords

  • Phenothiazines
  • Antimicrobial activity
  • Tuberculosis
  • Malaria
  • PLASMODIUM-FALCIPARUM
  • MYCOBACTERIUM-TUBERCULOSIS
  • METHYLENE-BLUE
  • IN-VITRO
  • POLYMORPHONUCLEAR LEUKOCYTES
  • BIOLOGICAL MACROMOLECULES
  • CHLOROQUINE RESISTANCE
  • ANTILEISHMANIAL DRUGS
  • STAPHYLOCOCCUS-AUREUS
  • IRREVERSIBLE BINDING

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