TY - JOUR
T1 - Phenothiazines alter resistance of methicillin-resistant strains of Staphylococcus aureus (MRSA) to oxacillin in vitro
AU - Kristiansen, Malthe M.
AU - Leandro, Clara
AU - Ordway, Diane
AU - Martins, Marta
AU - Viveiros, Miguel
AU - Pacheco, Teresa
AU - Kristiansen, Jette E.
AU - Amaral, Leonard
PY - 2003/9
Y1 - 2003/9
N2 - Mechanisms of antibiotic resistance of bacteria include efflux pumps which extrude the antibiotic prior to reaching its target. Phenothiazines inhibit the activity of some efflux pumps thereby altering the susceptibility of bacteria. This study demonstrated that chlorpromazine and thioridazine reduce the susceptibility of methicillin-resistant strains (MRSA) but not that of methicillin-susceptible Staphylococcus aureus (MSSA) strains to oxacillin (MIC of oxacillin reduced from >500 to 10 mg/l). Reserpine, an inhibitor of antibiotic efflux pumps also reduced the resistance of MRSA strains to oxacillin suggesting the presence of an efflux pump that contributes to antibiotic resistance of MRSA strains.
AB - Mechanisms of antibiotic resistance of bacteria include efflux pumps which extrude the antibiotic prior to reaching its target. Phenothiazines inhibit the activity of some efflux pumps thereby altering the susceptibility of bacteria. This study demonstrated that chlorpromazine and thioridazine reduce the susceptibility of methicillin-resistant strains (MRSA) but not that of methicillin-susceptible Staphylococcus aureus (MSSA) strains to oxacillin (MIC of oxacillin reduced from >500 to 10 mg/l). Reserpine, an inhibitor of antibiotic efflux pumps also reduced the resistance of MRSA strains to oxacillin suggesting the presence of an efflux pump that contributes to antibiotic resistance of MRSA strains.
KW - Methicillin and fluoroquinolone resistance
KW - Phenothiazines
KW - Reversal of antibiotic resistance
KW - Staphylococcus aureus
UR - http://www.scopus.com/inward/record.url?scp=0042334473&partnerID=8YFLogxK
UR - https://www.sciencedirect.com/science/article/abs/pii/S0924857903002000?via%3Dihub
U2 - 10.1016/S0924-8579(03)00200-0
DO - 10.1016/S0924-8579(03)00200-0
M3 - Article
C2 - 13678829
AN - SCOPUS:0042334473
VL - 22
SP - 250
EP - 253
JO - International Journal Of Antimicrobial Agents
JF - International Journal Of Antimicrobial Agents
SN - 0924-8579
IS - 3
ER -
