Phenothiazines alter resistance of methicillin-resistant strains of Staphylococcus aureus (MRSA) to oxacillin in vitro

Malthe M. Kristiansen; Clara Leandro; Diane Ordway; Marta Martins; Miguel Viveiros; Teresa Pacheco; Jette E. Kristiansen; Leonard Amaral

doi:10.1016/S0924-8579(03)00200-0

Phenothiazines alter resistance of methicillin-resistant strains of Staphylococcus aureus (MRSA) to oxacillin in vitro

Malthe M. Kristiansen, Clara Leandro, Diane Ordway, Marta Martins, Miguel Viveiros, Teresa Pacheco, Jette E. Kristiansen, Leonard Amaral

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65 Citations (Scopus)

Abstract

Mechanisms of antibiotic resistance of bacteria include efflux pumps which extrude the antibiotic prior to reaching its target. Phenothiazines inhibit the activity of some efflux pumps thereby altering the susceptibility of bacteria. This study demonstrated that chlorpromazine and thioridazine reduce the susceptibility of methicillin-resistant strains (MRSA) but not that of methicillin-susceptible Staphylococcus aureus (MSSA) strains to oxacillin (MIC of oxacillin reduced from >500 to 10 mg/l). Reserpine, an inhibitor of antibiotic efflux pumps also reduced the resistance of MRSA strains to oxacillin suggesting the presence of an efflux pump that contributes to antibiotic resistance of MRSA strains.

Original language	English
Pages (from-to)	250-253
Number of pages	4
Journal	International Journal Of Antimicrobial Agents
Volume	22
Issue number	3
DOIs	https://doi.org/10.1016/S0924-8579(03)00200-0
Publication status	Published - Sept 2003

Keywords

Methicillin and fluoroquinolone resistance
Phenothiazines
Reversal of antibiotic resistance
Staphylococcus aureus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0924-8579(03)00200-0

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abstract = "Mechanisms of antibiotic resistance of bacteria include efflux pumps which extrude the antibiotic prior to reaching its target. Phenothiazines inhibit the activity of some efflux pumps thereby altering the susceptibility of bacteria. This study demonstrated that chlorpromazine and thioridazine reduce the susceptibility of methicillin-resistant strains (MRSA) but not that of methicillin-susceptible Staphylococcus aureus (MSSA) strains to oxacillin (MIC of oxacillin reduced from >500 to 10 mg/l). Reserpine, an inhibitor of antibiotic efflux pumps also reduced the resistance of MRSA strains to oxacillin suggesting the presence of an efflux pump that contributes to antibiotic resistance of MRSA strains.",

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AU - Kristiansen, Malthe M.

AU - Leandro, Clara

AU - Ordway, Diane

AU - Martins, Marta

AU - Viveiros, Miguel

AU - Pacheco, Teresa

AU - Kristiansen, Jette E.

AU - Amaral, Leonard

PY - 2003/9

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AB - Mechanisms of antibiotic resistance of bacteria include efflux pumps which extrude the antibiotic prior to reaching its target. Phenothiazines inhibit the activity of some efflux pumps thereby altering the susceptibility of bacteria. This study demonstrated that chlorpromazine and thioridazine reduce the susceptibility of methicillin-resistant strains (MRSA) but not that of methicillin-susceptible Staphylococcus aureus (MSSA) strains to oxacillin (MIC of oxacillin reduced from >500 to 10 mg/l). Reserpine, an inhibitor of antibiotic efflux pumps also reduced the resistance of MRSA strains to oxacillin suggesting the presence of an efflux pump that contributes to antibiotic resistance of MRSA strains.

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KW - Phenothiazines

KW - Reversal of antibiotic resistance

KW - Staphylococcus aureus

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Phenothiazines alter resistance of methicillin-resistant strains of Staphylococcus aureus (MRSA) to oxacillin in vitro

Abstract

Keywords

UN SDGs

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