Phase equilibrium for capsaicin + water + ethanol + supercritical carbon dioxide

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29 Citations (Scopus)


The possibility of extracting capsaicin with supercritical carbon dioxide from a hydroalcholic mixture containing the alkaloid was investigated. High-pressure phase equilibrium on the quaternary system CO2 + ethanol + water + capsaicin was measured in order to obtain the separation factor of the natural product from hydro-alcoholic model mixtures. Experiments on phase equilibrium behavior were performed at several pressures (12, 15 and 18 MPa) and temperatures of 40 and 50°C. The separation factors for three mixtures of different composition - 0.40 water + 0.60 ethanol mass fraction and 0.9 water + 0.10 ethanol mass fraction, containing 0.02% of capsaicin and 0.40 water mass fraction containing 0.04% of capsaicin - are compared. The effect of the water content in the selectivity of the extraction process is discussed.

Original languageEnglish
Pages (from-to)87-92
Number of pages6
JournalJournal of Supercritical Fluids
Issue number2
Publication statusPublished - 2002


  • Alkaloids
  • Capsaicin
  • Hydroalcoholic mixtures
  • Supercritical fluid extraction
  • Vapor-liquid equilibrium


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