pH-responsive phthalate cashew gum nanoparticles for improving drugs delivery and anti-Trypanosoma cruzi efficacy

Antônia Carla de Jesus Oliveira, Emilliany Bárbara Silva, Thaisa Cardoso de Oliveira, Fábio de Oliveira Silva Ribeiro, Daniella Nadvorny, Johny Wysllas de Freitas Oliveira, Ana Borrego-Sánchez, Klinger Antonio da Franca Rodrigues, Marcelo Sousa Silva, Pedro José Rolim-Neto, César Viseras, Edson C. Silva-Filho, Durcilene Alves da Silva, Luíse Lopes Chaves, Mônica Felts de La Roca Soares, José Lamartine Soares-Sobrinho

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)
14 Downloads (Pure)

Abstract

Nanotechnology is a crucial technology in recent years has resulted in new and creative applications of nanomedicine. Polymeric nanoparticles have increasing demands in pharmaceutical applications and require high reproducibility, homogeneity, and control over their properties. Work explores the use of cashew phthalate gum (PCG) as a particle-forming polymer. PCG exhibited a pH-sensitive behavior due to the of acid groups on its chains, and control drug release. We report the development of nanoparticles carrying benznidazole. Formulations were characterized by DLS, encapsulation efficiency, drug loading, FTIR, pH-responsive behavior, release, and in vitro kinetics. Interaction between polymer and drug was an evaluated by molecular dynamics. Morphology was observed by SEM, and in vitro cytotoxicity by MTT assay. Trypanocidal effect for epimastigote and trypomastigote forms was also evaluated. NPs responded to the slightly basic pH, triggering the release of BNZ. In acidic medium, they presented small size, spherical shape, and good stability. It was indicated NP with enhanced biological activity, reduced cytotoxicity, high anti T. cruzi performance, and pH-sensitive release. This work investigated properties related to the development and enhancement of nanoparticles. PCG has specific physicochemical properties that make it a promising alternative to drug delivery, however, there are still challenges to be overcome.

Original languageEnglish
Article number123272
Number of pages13
JournalInternational Journal of Biological Macromolecules
Volume230
DOIs
Publication statusPublished - 1 Mar 2023

Keywords

  • Anti-Trypanosoma cruzi
  • Benznidazole
  • Cashew gum polysaccharides
  • Chemical modification
  • Plackett-Burman design
  • Polymeric nanoparticles

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