Persistency of low levels of anticardiolipin and anti-Beta2 Glycoprotein1 in thrombosis

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Abstract

Background Antiphospholipid antibodies, the hallmark of the antiphospholipid syndrome, are associated with both venous and arterial thrombosis Despite some reports stating that this association may be present in patients with low tares of anticardiolipin antibodies, a clear association has only been established in the presence of a moderate to high concentrations (above 40 GPL or MPL) Methods In order to study whether low antibody titres could be associated with thrombosis, we reviewed the files of 196 patients, 94 with and 102 without thrombotic events, for a penal of 4 4 and 5 1 years respectively Files from patients with persistent low titres of antiphospholipid antibodies recorded in the unit database were selected, independently of the associated clinical history or diagnosis Epidemiology, clinical and treatment information were collected and the serum variability of the antibody titres was analysed in relation to the presence of thiombotic events Results Thrombotic events were classified as venous 81 9% and arterial 18 1% 23/94 (24 5%) patients with thrombosis had miscarriages There were no significant differences between serum concentrations of antiphospholipid antibodies m the thrombotic and non-thrombotic groups However, there was a higher consistency of the antibody concentrations in patients with thrombosis, as seen by the significantly lower variability of IgG aCL and a beta 2GPI titres m patients with thrombosis when compared to non-thrombotic controls (p = 0 0025 and p < 0 0001. respectively) Conclusion Consistency of low titres of antiphospholipid antibody levels may be associated with a higher risk of thrombotic events overall (C) 2009 European Federation of Internal Medicine Published by Elsevier B V All rights reserved
Original languageEnglish
Pages (from-to)101-103
Number of pages3
JournalEuropean Journal Of Internal Medicine
Volume21
Issue number2
DOIs
Publication statusPublished - 2010

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