Persistence of measles antibodies, following changes in the recommended age for the second dose of MMR-vaccine in Portugal

Guilherme Gonçalves, João Frade, Carla Nunes, João Rodrigo Mesquita, Maria São José Nascimento

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Abstract

In populations vaccinated with two doses of combined measles-mumps-rubella vaccine (MMR), the serum levels of antibodies against measles depend on the vaccination schedule, time elapsed from the last dose and the area-specific epidemiological situation. Variables measuring "schedule" are age at first and second doses of MMR and intervals derived from that. Changes in vaccination schedules have been made in Portugal. The specific objectives of this study were to measure the association between those potential determinants and the concentration of measles-specific IgG antibodies, after the second dose of MMR. Convenience samples of three Portuguese birth cohorts were selected for this study (41, 66 and 60 born, respectively, in 2001-2003, 1990-1993 and 1994-1995). Geometric mean concentrations (GMC) for measles IgG were, respectively, 934, 251 and 144. mIU/ml; p

Original languageEnglish
Pages (from-to)5057-5063
Number of pages7
JournalVaccine
Volume33
Issue number39
DOIs
Publication statusPublished - 22 Sep 2015

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Keywords

  • Antibodies
  • Immunisation
  • Measles
  • Measles-mumps-rubella (MMR) vaccine
  • Vaccination schedule

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