TY - JOUR
T1 - Persistence of measles antibodies, following changes in the recommended age for the second dose of MMR-vaccine in Portugal
AU - Gonçalves, Guilherme
AU - Frade, João
AU - Nunes, Carla
AU - Mesquita, João Rodrigo
AU - Nascimento, Maria São José
N1 - PMID: 26319061
Scopus: 84941739145
WOS: 000361862900006
PY - 2015/9/22
Y1 - 2015/9/22
N2 - In populations vaccinated with two doses of combined measles-mumps-rubella vaccine (MMR), the serum levels of antibodies against measles depend on the vaccination schedule, time elapsed from the last dose and the area-specific epidemiological situation. Variables measuring "schedule" are age at first and second doses of MMR and intervals derived from that. Changes in vaccination schedules have been made in Portugal. The specific objectives of this study were to measure the association between those potential determinants and the concentration of measles-specific IgG antibodies, after the second dose of MMR. Convenience samples of three Portuguese birth cohorts were selected for this study (41, 66 and 60 born, respectively, in 2001-2003, 1990-1993 and 1994-1995). Geometric mean concentrations (GMC) for measles IgG were, respectively, 934, 251 and 144. mIU/ml; p
AB - In populations vaccinated with two doses of combined measles-mumps-rubella vaccine (MMR), the serum levels of antibodies against measles depend on the vaccination schedule, time elapsed from the last dose and the area-specific epidemiological situation. Variables measuring "schedule" are age at first and second doses of MMR and intervals derived from that. Changes in vaccination schedules have been made in Portugal. The specific objectives of this study were to measure the association between those potential determinants and the concentration of measles-specific IgG antibodies, after the second dose of MMR. Convenience samples of three Portuguese birth cohorts were selected for this study (41, 66 and 60 born, respectively, in 2001-2003, 1990-1993 and 1994-1995). Geometric mean concentrations (GMC) for measles IgG were, respectively, 934, 251 and 144. mIU/ml; p
KW - Antibodies
KW - Immunisation
KW - Measles
KW - Measles-mumps-rubella (MMR) vaccine
KW - Vaccination schedule
UR - http://www.scopus.com/inward/record.url?scp=84941739145&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2015.08.057
DO - 10.1016/j.vaccine.2015.08.057
M3 - Article
C2 - 26319061
AN - SCOPUS:84941739145
SN - 0264-410X
VL - 33
SP - 5057
EP - 5063
JO - Vaccine
JF - Vaccine
IS - 39
ER -
