TY - JOUR
T1 - Pericardium, epicardial adipose tissue, and heart failure with preserved ejection fraction
T2 - Pathophysiology, quantification and treatment target
AU - Timóteo, Ana Teresa
AU - Barbas Albuquerque, Francisco
AU - Lacerda Teixeira, Bárbara
PY - 2024/10/1
Y1 - 2024/10/1
N2 - Heart failure is an important cause of mortality and morbidity worldwide. Heart failure with preserved ejection fraction (HFpEF) incidence and prevalence is increasing, and the phenotype associated with obesity is the most frequent. Epicardial adipose tissue (EAT) is directly associated with systemic obesity and several previous studies have shown a clear link between EAT and HFpEF. Moreover, the restriction induced by the pericardium is also linked to HFpEF. In this review we will describe the epidemiological association between the pericardium, EAT and HFpEF, how to quantify EAT, what are the pathophysiological mechanism to explain theses association and how can the pericardium and EAT be a treatment target in patients with HFpEF.
AB - Heart failure is an important cause of mortality and morbidity worldwide. Heart failure with preserved ejection fraction (HFpEF) incidence and prevalence is increasing, and the phenotype associated with obesity is the most frequent. Epicardial adipose tissue (EAT) is directly associated with systemic obesity and several previous studies have shown a clear link between EAT and HFpEF. Moreover, the restriction induced by the pericardium is also linked to HFpEF. In this review we will describe the epidemiological association between the pericardium, EAT and HFpEF, how to quantify EAT, what are the pathophysiological mechanism to explain theses association and how can the pericardium and EAT be a treatment target in patients with HFpEF.
KW - Epicardial adipose tissue
KW - Heart failure with preserved ejection fraction
KW - Pericardium
UR - http://www.scopus.com/inward/record.url?scp=85197024617&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2024.132303
DO - 10.1016/j.ijcard.2024.132303
M3 - Review article
AN - SCOPUS:85197024617
SN - 0167-5273
VL - 412
JO - International Journal of Cardiology
JF - International Journal of Cardiology
M1 - 132303
ER -