Performance of Prognostic Risk Scores in Chronic Heart Failure Patients Enrolled in the European Society of Cardiology Heart Failure Long-Term Registry

Marco Canepa, Candida Fonseca, O. Chioncel, Cécile Laroche, M. Crespo-Leiro, Andrew J.S. Coats, A. Mebazaa, M. F. Piepoli, Luigi Tavazzi, A. P. Maggioni, M. Crespo-Leiro, S. Anker, A. Mebazaa, A. Coats, G. Filippatos, R. Ferrari, A. P. Maggioni, M. F. Piepoli, O. Amir, O. Chioncel & 611 others U. Dahlström, J. F. Delgado Jimenez, J. Drozdz, A. Erglis, E. Fazlibegovic, C. Fonseca, F. Fruhwald, P. Gatzov, E. Goncalvesova, M. Hassanein, J. Hradec, A. Kavoliuniene, M. Lainscak, D. Logeart, B. Merkely, M. Metra, M. Otljanska, P. M. Seferovic, E. Srbinovska Kostovska, A. Temizhan, D. Tousoulis, T. Ferreira, M. Andarala, E. Fiorucci, E. Folkesson Lefrancq, M. Glémot, G. Gracia, M. Konte, C. Laroche, P. A. McNeill, V. Missiamenou, C. Taylor, J. Auer, K. Ablasser, T. Dolze, K. Brandner, S. Gstrein, G. Poelzl, D. Moertl, S. Reiter, A. Podczeck-Schweighofer, A. Muslibegovic, M. Vasilj, M. Cesko, D. Zelenika, B. Palic, D. Pravdic, D. Cuk, K. Vitlianova, T. Katova, T. Velikov, T. Kurteva, D. Kamenova, M. Antova, V. Sirakova, J. Krejci, M. Mikolaskova, J. Spinar, J. Krupicka, F. Malek, M. Hegarova, M. Lazarova, Z. Monhart, M. Sobhy, F. El Messiry, A. H. El Shazly, Y. Elrakshy, A. Youssef, A. A. Moneim, M. Noamany, A. Reda, T. K. Abdel Dayem, N. Farag, S. Ibrahim Halawa, M. Abdel Hamid, K. Said, A. Saleh, H. Ebeid, R. Hanna, R. Aziz, O. Louis, M. A. Enen, B. S. Ibrahim, G. Nasr, A. Elbahry, H. Sobhy, M. Ashmawy, M. Gouda, W. Aboleineen, Y. Bernard, P. Luporsi, N. Meneveau, M. Pillot, M. Morel, M. F. Seronde, F. Schiele, F. Briand, F. Delahaye, T. Damy, J. C. Eicher, P. de Groote, M. Fertin, N. Lamblin, R. Isnard, C. Lefol, S. Thevenin, A. Hagege, G. Jondeau, V. Le Marcis, J. F. Ly, D. Coisne, B. Lequeux, V. Le Moal, S. Mascle, P. Lotton, N. Behar, E. Donal, C. Thebault, C. Ridard, A. Reynaud, A. Basquin, F. Bauer, R. Codjia, M. Galinier, P. Tourikis, M. Stavroula, C. Stefanadis, C. Chrysohoou, I. Kotrogiannis, V. Matzaraki, T. Dimitroula, A. Karavidas, G. Tsitsinakis, C. Kapelios, J. Nanas, H. Kampouri, E. Nana, E. Kaldara, A. Eugenidou, P. Vardas, I. Saloustros, A. Patrianakos, T. Tsaknakis, S. Evangelou, N. Nikoloulis, H. Tziourganou, A. Tsaroucha, A. Papadopoulou, A. Douras, L. Polgar, A. Kosztin, N. Nyolczas, A. Csaba Nagy, R. Halmosi, J. Elber, I. Alony, A. Shotan, A. Vazan Fuhrmann, S. Romano, S. Marcon, M. Penco, M. Di Mauro, E. Lemme, V. Carubelli, R. Rovetta, M. Bulgari, F. Quinzani, C. Lombardi, S. Bosi, G. Schiavina, A. Squeri, A. Barbieri, G. Di Tano, S. Pirelli, A. Fucili, T. Passero, S. Musio, M. Di Biase, M. Correale, G. Salvemini, S. Brognoli, E. Zanelli, A. Giordano, P. Agostoni, G. Italiano, E. Salvioni, S. Copelli, M. G. Modena, L. Reggianini, C. Valenti, A. Olaru, S. Bandino, M. Deidda, G. Mercuro, C. Cadeddu Dessalvi, P. N. Marino, M. V. Di Ruocco, C. Sartori, C. Piccinino, G. Parrinello, G. Licata, D. Torres, S. Giambanco, S. Busalacchi, S. Arrotti, S. Novo, R. M. Inciardi, P. Pieri, P. R. Chirco, M. Ausilia Galifi, G. Teresi, D. Buccheri, A. Minacapelli, M. Veniani, A. Frisinghelli, S. G. Priori, S. Cattaneo, C. Opasich, A. Gualco, M. Pagliaro, M. Mancone, F. Fedele, A. Cinque, M. Vellini, I. Scarfo, F. Romeo, F. Ferraiuolo, D. Sergi, M. Anselmi, F. Melandri, E. Leci, E. Iori, V. Bovolo, S. Pidello, S. Frea, S. Bergerone, M. Botta, F. G. Canavosio, F. Gaita, M. Merlo, M. Cinquetti, G. Sinagra, F. Ramani, E. Fabris, D. Stolfo, J. Artico, D. Miani, C. Fresco, C. Daneluzzi, A. Proclemer, M. Cicoira, L. Zanolla, G. Marchese, F. Torelli, C. Vassanelli, N. Voronina, V. Tamakauskas, V. Smalinskas, R. Karaliute, I. Petraskiene, E. Kazakauskaite, E. Rumbinaite, V. Vysniauskas, R. Brazyte-Ramanauskiene, D. Petraskiene, S. Stankala, P. Switala, Z. Juszczyk, W. Sinkiewicz, W. Gilewski, J. Pietrzak, T. Orzel, P. Kasztelowicz, P. Kardaszewicz, M. Lazorko-Piega, J. Gabryel, K. Mosakowska, J. Bellwon, A. Rynkiewicz, G. Raczak, E. Lewicka, A. Dabrowska-Kugacka, R. Bartkowiak, B. Sosnowska-Pasiarska, B. Wozakowska-Kaplon, A. Krzeminski, M. Zabojszcz, E. Mirek-Bryniarska, A. Grzegorzko, K. Bury, J. Nessler, J. Zalewski, A. Furman, M. Broncel, A. Poliwczak, A. Bala, P. Zycinski, M. Rudzinska, L. Jankowski, J. D. Kasprzak, L. Michalak, K. Wojtczak Soska, I. Huziuk, A. Retwinski, P. Flis, J. Weglarz, A. Bodys, S. Grajek, M. Kaluzna-Oleksy, E. Straburzynska-Migaj, R. Dankowski, K. Szymanowska, J. Grabia, A. Szyszka, A. Nowicka, M. Samcik, L. Wolniewicz, K. Baczynska, K. Komorowska, I. Poprawa, E. Komorowska, D. Sajnaga, A. Zolbach, A. Dudzik-Plocica, A. F. Abdulkarim, A. Lauko-Rachocka, L. Kaminski, A. Kostka, A. Cichy, P. Ruszkowski, M. Splawski, G. Fitas, A. Szymczyk, A. Serwicka, A. Fiega, D. Zysko, W. Krysiak, S. Szabowski, E. Skorek, P. Pruszczyk, P. Bienias, M. Ciurzynski, M. Welnicki, A. Mamcarz, A. Folga, T. Zielinski, T. Rywik, P. Leszek, M. Sobieszczanska-Malek, M. Piotrowska, K. Kozar-Kaminska, K. Komuda, J. Wisniewska, A. Tarnowska, P. Balsam, M. Marchel, G. Opolski, A. Kaplon-Cieslicka, R. J. Gil, O. Mozenska, K. Byczkowska, K. Gil, A. Pawlak, A. Michalek, P. Krzesinski, K. Piotrowicz, B. Uzieblo-Zyczkowska, A. Stanczyk, A. Skrobowski, P. Ponikowski, E. Jankowska, P. Rozentryt, L. Polonski, E. Gadula-Gacek, E. Nowalany-Kozielska, A. Kuczaj, Z. Kalarus, M. Szulik, K. Przybylska, J. Klys, G. Prokop-Lewicka, A. Kleinrok, C. Tavares Aguiar, A. Ventosa, S. Pereira, R. Faria, J. Chin, I. De Jesus, R. Santos, P. Silva, N. Moreno, C. Queirós, C. Lourenço, A. Pereira, A. Castro, A. Andrade, T. Oliveira Guimaraes, S. Martins, R. Placido, G. Lima, D. Brito, A. R. Francisco, R. Cardiga, M. Proenca, I. Araujo, F. Marques, B. Moura, S. Leite, M. Campelo, J. Silva-Cardoso, J. Rodrigues, I. Rangel, E. Martins, A. Sofia Correia, M. Peres, L. Marta, G. Ferreira da Silva, D. Severino, D. Durao, S. Leao, P. Magalhaes, I. Moreira, A. Filipa Cordeiro, C. Ferreira, C. Araujo, A. Ferreira, A. Baptista, M. Radoi, G. Bicescu, D. Vinereanu, C. J. Sinescu, C. Macarie, R. Popescu, I. Daha, G. A. Dan, C. Stanescu, A. Dan, E. Craiu, E. Nechita, V. Aursulesei, R. Christodorescu, P. Otasevic, D. Simeunovic, A. D. Ristic, V. Celic, M. Pavlovic-Kleut, J. Suzic Lazic, B. Stojcevski, B. Pencic, A. Stevanovic, A. Andric, V. Iric-Cupic, M. Jovic, G. Davidovic, S. Milanov, V. Mitic, V. Atanaskovic, S. Antic, M. Pavlovic, D. Stanojevic, V. Stoickov, S. Ilic, M. Deljanin Ilic, D. Petrovic, S. Stojsic, S. Kecojevic, S. Dodic, N. Cemerlic Adic, M. Cankovic, J. Stojiljkovic, B. Mihajlovic, A. Radin, S. Radovanovic, M. Krotin, A. Klabnik, M. Pernicky, J. Murin, F. Kovar, J. Kmec, H. Semjanova, M. Strasek, M. Savnik Iskra, T. Ravnikar, N. Cernic Suligoj, J. Komel, Z. Fras, B. Jug, T. Glavic, R. Losic, M. Bombek, I. Krajnc, B. Krunic, S. Horvat, D. Kovac, D. Rajtman, V. Cencic, M. Letonja, R. Winkler, M. Valentincic, C. Melihen-Bartolic, A. Bartolic, M. Pusnik Vrckovnik, M. Kladnik, C. Slemenik Pusnik, A. Marolt, J. Klen, B. Drnovsek, B. Leskovar, M. J. Fernandez Anguita, J. C. Gallego Page, F. M. Salmeron Martinez, J. Andres, A. B. Genis, S. Mirabet, A. Mendez, L. Garcia-Cosio, E. Roig, V. Leon, J. Gonzalez-Costello, G. Muntane, A. Garay, V. Alcade-Martinez, S. Lopez Fernandez, R. Rivera-Lopez, M. Puga-Martinez, M. Fernandez-Alvarez, J. L. Serrano-Martinez, Z. Grille-Cancela, R. Marzoa-Rivas, P. Blanco-Canosa, M. J. Paniagua-Martin, E. Barge-Caballero, I. Laynez Cerdena, I. Famara Hernandez Baldomero, A. Lara Padron, S. Ofelia Rosillo, R. Dalmau Gonzalez-Gallarza, O. Salvador Montanes, A. M. Iniesta Manjavacas, A. Castro Conde, A. Araujo, T. Soria, P. Garcia-Pavia, M. Gomez-Bueno, M. Cobo-Marcos, L. Alonso-Pulpon, J. Segovia Cubero, I. Sayago, A. Gonzalez-Segovia, A. Briceno, P. Escribano Subias, M. Vicente Hernandez, M. J. Ruiz Cano, M. A. Gomez Sanchez, E. Barrios Garrido-Lestache, J. M. Garcia Pinilla, B. Garcia de la Villa, A. Sahuquillo, R. Bravo Marques, F. Torres Calvo, M. T. Perez-Martinez, M. R. Gracia-Rodenas, I. P. Garrido-Bravo, F. Pastor-Perez, D. A. Pascual-Figal, B. Diaz Molina, J. Orus, F. Epelde Gonzalo, V. Bertomeu, R. Valero, R. Martinez-Abellan, J. Quiles, J. A. Rodrigez-Ortega, I. Mateo, A. ElAmrani, C. Fernandez-Vivancos, D. Bierge Valero, L. Almenar-Bonet, I. J. Sanchez-Lazaro, E. Marques-Sule, L. Facila-Rubio, J. Perez-Silvestre, P. Garcia-Gonzalez, F. Ridocci-Soriano, D. Garcia-Escriva, A. Pellicer-Cabo, L. de la Fuente Galan, J. Lopez Diaz, A. Recio Platero, J. C. Arias, T. Blasco-Peiro, M. Sanz Julve, E. Sanchez-Insa, C. Aured-Guallar, A. Portoles-Ocampo, M. Melin, E. Hägglund, A. Stenberg, I. M. Lindahl, B. Asserlund, L. Olsson, M. Afzelius, P. Karlström, L. Tengvall, P. A. Wiklund, B. Olsson, S. Kalayci, Y. Cavusoglu, E. Gencer, M. B. Yilmaz, H. Gunes

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objectives: This study compared the performance of major heart failure (HF) risk models in predicting mortality and examined their utilization using data from a contemporary multinational registry. Background: Several prognostic risk scores have been developed for ambulatory HF patients, but their precision is still inadequate and their use limited. Methods: This registry enrolled patients with HF seen in participating European centers between May 2011 and April 2013. The following scores designed to estimate 1- to 2-year all-cause mortality were calculated in each participant: CHARM (Candesartan in Heart Failure-Assessment of Reduction in Mortality), GISSI-HF (Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico-Heart Failure), MAGGIC (Meta-analysis Global Group in Chronic Heart Failure), and SHFM (Seattle Heart Failure Model). Patients with hospitalized HF (n = 6,920) and ambulatory HF patients missing any variable needed to estimate each score (n = 3,267) were excluded, leaving a final sample of 6,161 patients. Results: At 1-year follow-up, 5,653 of 6,161 patients (91.8%) were alive. The observed-to-predicted survival ratios (CHARM: 1.10, GISSI-HF: 1.08, MAGGIC: 1.03, and SHFM: 0.98) suggested some overestimation of mortality by all scores except the SHFM. Overprediction occurred steadily across levels of risk using both the CHARM and the GISSI-HF, whereas the SHFM underpredicted mortality in all risk groups except the highest. The MAGGIC showed the best overall accuracy (area under the curve [AUC] = 0.743), similar to the GISSI-HF (AUC = 0.739; p = 0.419) but better than the CHARM (AUC = 0.729; p = 0.068) and particularly better than the SHFM (AUC = 0.714; p = 0.018). Less than 1% of patients received a prognostic estimate from their enrolling physician. Conclusions: Performance of prognostic risk scores is still limited and physicians are reluctant to use them in daily practice. The need for contemporary, more precise prognostic tools should be considered.

Original languageEnglish
Pages (from-to)452-462
Number of pages11
JournalJACC: Heart Failure
Volume6
Issue number6
DOIs
Publication statusPublished - 1 Jun 2018

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Registries
Heart Failure
Mortality
Area Under Curve
Meta-Analysis
Physicians

Keywords

  • heart failure
  • mortality
  • prognosis
  • risk score

Cite this

Canepa, Marco ; Fonseca, Candida ; Chioncel, O. ; Laroche, Cécile ; Crespo-Leiro, M. ; Coats, Andrew J.S. ; Mebazaa, A. ; Piepoli, M. F. ; Tavazzi, Luigi ; Maggioni, A. P. ; Crespo-Leiro, M. ; Anker, S. ; Mebazaa, A. ; Coats, A. ; Filippatos, G. ; Ferrari, R. ; Maggioni, A. P. ; Piepoli, M. F. ; Amir, O. ; Chioncel, O. ; Dahlström, U. ; Delgado Jimenez, J. F. ; Drozdz, J. ; Erglis, A. ; Fazlibegovic, E. ; Fonseca, C. ; Fruhwald, F. ; Gatzov, P. ; Goncalvesova, E. ; Hassanein, M. ; Hradec, J. ; Kavoliuniene, A. ; Lainscak, M. ; Logeart, D. ; Merkely, B. ; Metra, M. ; Otljanska, M. ; Seferovic, P. M. ; Srbinovska Kostovska, E. ; Temizhan, A. ; Tousoulis, D. ; Ferreira, T. ; Andarala, M. ; Fiorucci, E. ; Folkesson Lefrancq, E. ; Glémot, M. ; Gracia, G. ; Konte, M. ; Laroche, C. ; McNeill, P. A. ; Missiamenou, V. ; Taylor, C. ; Auer, J. ; Ablasser, K. ; Dolze, T. ; Brandner, K. ; Gstrein, S. ; Poelzl, G. ; Moertl, D. ; Reiter, S. ; Podczeck-Schweighofer, A. ; Muslibegovic, A. ; Vasilj, M. ; Cesko, M. ; Zelenika, D. ; Palic, B. ; Pravdic, D. ; Cuk, D. ; Vitlianova, K. ; Katova, T. ; Velikov, T. ; Kurteva, T. ; Kamenova, D. ; Antova, M. ; Sirakova, V. ; Krejci, J. ; Mikolaskova, M. ; Spinar, J. ; Krupicka, J. ; Malek, F. ; Hegarova, M. ; Lazarova, M. ; Monhart, Z. ; Sobhy, M. ; El Messiry, F. ; El Shazly, A. H. ; Elrakshy, Y. ; Youssef, A. ; Moneim, A. A. ; Noamany, M. ; Reda, A. ; Abdel Dayem, T. K. ; Farag, N. ; Ibrahim Halawa, S. ; Abdel Hamid, M. ; Said, K. ; Saleh, A. ; Ebeid, H. ; Hanna, R. ; Aziz, R. ; Louis, O. ; Enen, M. A. ; Ibrahim, B. S. ; Nasr, G. ; Elbahry, A. ; Sobhy, H. ; Ashmawy, M. ; Gouda, M. ; Aboleineen, W. ; Bernard, Y. ; Luporsi, P. ; Meneveau, N. ; Pillot, M. ; Morel, M. ; Seronde, M. F. ; Schiele, F. ; Briand, F. ; Delahaye, F. ; Damy, T. ; Eicher, J. C. ; de Groote, P. ; Fertin, M. ; Lamblin, N. ; Isnard, R. ; Lefol, C. ; Thevenin, S. ; Hagege, A. ; Jondeau, G. ; Le Marcis, V. ; Ly, J. F. ; Coisne, D. ; Lequeux, B. ; Le Moal, V. ; Mascle, S. ; Lotton, P. ; Behar, N. ; Donal, E. ; Thebault, C. ; Ridard, C. ; Reynaud, A. ; Basquin, A. ; Bauer, F. ; Codjia, R. ; Galinier, M. ; Tourikis, P. ; Stavroula, M. ; Stefanadis, C. ; Chrysohoou, C. ; Kotrogiannis, I. ; Matzaraki, V. ; Dimitroula, T. ; Karavidas, A. ; Tsitsinakis, G. ; Kapelios, C. ; Nanas, J. ; Kampouri, H. ; Nana, E. ; Kaldara, E. ; Eugenidou, A. ; Vardas, P. ; Saloustros, I. ; Patrianakos, A. ; Tsaknakis, T. ; Evangelou, S. ; Nikoloulis, N. ; Tziourganou, H. ; Tsaroucha, A. ; Papadopoulou, A. ; Douras, A. ; Polgar, L. ; Kosztin, A. ; Nyolczas, N. ; Csaba Nagy, A. ; Halmosi, R. ; Elber, J. ; Alony, I. ; Shotan, A. ; Vazan Fuhrmann, A. ; Romano, S. ; Marcon, S. ; Penco, M. ; Di Mauro, M. ; Lemme, E. ; Carubelli, V. ; Rovetta, R. ; Bulgari, M. ; Quinzani, F. ; Lombardi, C. ; Bosi, S. ; Schiavina, G. ; Squeri, A. ; Barbieri, A. ; Di Tano, G. ; Pirelli, S. ; Fucili, A. ; Passero, T. ; Musio, S. ; Di Biase, M. ; Correale, M. ; Salvemini, G. ; Brognoli, S. ; Zanelli, E. ; Giordano, A. ; Agostoni, P. ; Italiano, G. ; Salvioni, E. ; Copelli, S. ; Modena, M. 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G. ; Gaita, F. ; Merlo, M. ; Cinquetti, M. ; Sinagra, G. ; Ramani, F. ; Fabris, E. ; Stolfo, D. ; Artico, J. ; Miani, D. ; Fresco, C. ; Daneluzzi, C. ; Proclemer, A. ; Cicoira, M. ; Zanolla, L. ; Marchese, G. ; Torelli, F. ; Vassanelli, C. ; Voronina, N. ; Tamakauskas, V. ; Smalinskas, V. ; Karaliute, R. ; Petraskiene, I. ; Kazakauskaite, E. ; Rumbinaite, E. ; Vysniauskas, V. ; Brazyte-Ramanauskiene, R. ; Petraskiene, D. ; Stankala, S. ; Switala, P. ; Juszczyk, Z. ; Sinkiewicz, W. ; Gilewski, W. ; Pietrzak, J. ; Orzel, T. ; Kasztelowicz, P. ; Kardaszewicz, P. ; Lazorko-Piega, M. ; Gabryel, J. ; Mosakowska, K. ; Bellwon, J. ; Rynkiewicz, A. ; Raczak, G. ; Lewicka, E. ; Dabrowska-Kugacka, A. ; Bartkowiak, R. ; Sosnowska-Pasiarska, B. ; Wozakowska-Kaplon, B. ; Krzeminski, A. ; Zabojszcz, M. ; Mirek-Bryniarska, E. ; Grzegorzko, A. ; Bury, K. ; Nessler, J. ; Zalewski, J. ; Furman, A. ; Broncel, M. ; Poliwczak, A. ; Bala, A. ; Zycinski, P. ; Rudzinska, M. ; Jankowski, L. ; Kasprzak, J. D. ; Michalak, L. ; Wojtczak Soska, K. ; Huziuk, I. ; Retwinski, A. ; Flis, P. ; Weglarz, J. ; Bodys, A. ; Grajek, S. ; Kaluzna-Oleksy, M. ; Straburzynska-Migaj, E. ; Dankowski, R. ; Szymanowska, K. ; Grabia, J. ; Szyszka, A. ; Nowicka, A. ; Samcik, M. ; Wolniewicz, L. ; Baczynska, K. ; Komorowska, K. ; Poprawa, I. ; Komorowska, E. ; Sajnaga, D. ; Zolbach, A. ; Dudzik-Plocica, A. ; Abdulkarim, A. F. ; Lauko-Rachocka, A. ; Kaminski, L. ; Kostka, A. ; Cichy, A. ; Ruszkowski, P. ; Splawski, M. ; Fitas, G. ; Szymczyk, A. ; Serwicka, A. ; Fiega, A. ; Zysko, D. ; Krysiak, W. ; Szabowski, S. ; Skorek, E. ; Pruszczyk, P. ; Bienias, P. ; Ciurzynski, M. ; Welnicki, M. ; Mamcarz, A. ; Folga, A. ; Zielinski, T. ; Rywik, T. ; Leszek, P. ; Sobieszczanska-Malek, M. ; Piotrowska, M. ; Kozar-Kaminska, K. ; Komuda, K. ; Wisniewska, J. ; Tarnowska, A. ; Balsam, P. ; Marchel, M. ; Opolski, G. ; Kaplon-Cieslicka, A. ; Gil, R. J. ; Mozenska, O. ; Byczkowska, K. ; Gil, K. ; Pawlak, A. ; Michalek, A. ; Krzesinski, P. ; Piotrowicz, K. ; Uzieblo-Zyczkowska, B. ; Stanczyk, A. ; Skrobowski, A. ; Ponikowski, P. ; Jankowska, E. ; Rozentryt, P. ; Polonski, L. ; Gadula-Gacek, E. ; Nowalany-Kozielska, E. ; Kuczaj, A. ; Kalarus, Z. ; Szulik, M. ; Przybylska, K. ; Klys, J. ; Prokop-Lewicka, G. ; Kleinrok, A. ; Tavares Aguiar, C. ; Ventosa, A. ; Pereira, S. ; Faria, R. ; Chin, J. ; De Jesus, I. ; Santos, R. ; Silva, P. ; Moreno, N. ; Queirós, C. ; Lourenço, C. ; Pereira, A. ; Castro, A. ; Andrade, A. ; Oliveira Guimaraes, T. ; Martins, S. ; Placido, R. ; Lima, G. ; Brito, D. ; Francisco, A. R. ; Cardiga, R. ; Proenca, M. ; Araujo, I. ; Marques, F. ; Moura, B. ; Leite, S. ; Campelo, M. ; Silva-Cardoso, J. ; Rodrigues, J. ; Rangel, I. ; Martins, E. ; Sofia Correia, A. ; Peres, M. ; Marta, L. ; Ferreira da Silva, G. ; Severino, D. ; Durao, D. ; Leao, S. ; Magalhaes, P. ; Moreira, I. ; Filipa Cordeiro, A. ; Ferreira, C. ; Araujo, C. ; Ferreira, A. ; Baptista, A. ; Radoi, M. ; Bicescu, G. ; Vinereanu, D. ; Sinescu, C. J. ; Macarie, C. ; Popescu, R. ; Daha, I. ; Dan, G. A. ; Stanescu, C. ; Dan, A. ; Craiu, E. ; Nechita, E. ; Aursulesei, V. ; Christodorescu, R. ; Otasevic, P. ; Simeunovic, D. ; Ristic, A. D. ; Celic, V. ; Pavlovic-Kleut, M. ; Suzic Lazic, J. ; Stojcevski, B. ; Pencic, B. ; Stevanovic, A. ; Andric, A. ; Iric-Cupic, V. ; Jovic, M. ; Davidovic, G. ; Milanov, S. ; Mitic, V. ; Atanaskovic, V. ; Antic, S. ; Pavlovic, M. ; Stanojevic, D. ; Stoickov, V. ; Ilic, S. ; Deljanin Ilic, M. ; Petrovic, D. ; Stojsic, S. ; Kecojevic, S. ; Dodic, S. ; Cemerlic Adic, N. ; Cankovic, M. ; Stojiljkovic, J. ; Mihajlovic, B. ; Radin, A. ; Radovanovic, S. ; Krotin, M. ; Klabnik, A. ; Pernicky, M. ; Murin, J. ; Kovar, F. ; Kmec, J. ; Semjanova, H. ; Strasek, M. ; Savnik Iskra, M. ; Ravnikar, T. ; Cernic Suligoj, N. ; Komel, J. ; Fras, Z. ; Jug, B. ; Glavic, T. ; Losic, R. ; Bombek, M. ; Krajnc, I. ; Krunic, B. ; Horvat, S. ; Kovac, D. ; Rajtman, D. ; Cencic, V. ; Letonja, M. ; Winkler, R. ; Valentincic, M. ; Melihen-Bartolic, C. ; Bartolic, A. ; Pusnik Vrckovnik, M. ; Kladnik, M. ; Slemenik Pusnik, C. ; Marolt, A. ; Klen, J. ; Drnovsek, B. ; Leskovar, B. ; Fernandez Anguita, M. J. ; Gallego Page, J. C. ; Salmeron Martinez, F. M. ; Andres, J. ; Genis, A. B. ; Mirabet, S. ; Mendez, A. ; Garcia-Cosio, L. ; Roig, E. ; Leon, V. ; Gonzalez-Costello, J. ; Muntane, G. ; Garay, A. ; Alcade-Martinez, V. ; Lopez Fernandez, S. ; Rivera-Lopez, R. ; Puga-Martinez, M. ; Fernandez-Alvarez, M. ; Serrano-Martinez, J. L. ; Grille-Cancela, Z. ; Marzoa-Rivas, R. ; Blanco-Canosa, P. ; Paniagua-Martin, M. J. ; Barge-Caballero, E. ; Laynez Cerdena, I. ; Famara Hernandez Baldomero, I. ; Lara Padron, A. ; Ofelia Rosillo, S. ; Dalmau Gonzalez-Gallarza, R. ; Salvador Montanes, O. ; Iniesta Manjavacas, A. M. ; Castro Conde, A. ; Araujo, A. ; Soria, T. ; Garcia-Pavia, P. ; Gomez-Bueno, M. ; Cobo-Marcos, M. ; Alonso-Pulpon, L. ; Segovia Cubero, J. ; Sayago, I. ; Gonzalez-Segovia, A. ; Briceno, A. ; Escribano Subias, P. ; Vicente Hernandez, M. ; Ruiz Cano, M. J. ; Gomez Sanchez, M. A. ; Barrios Garrido-Lestache, E. ; Garcia Pinilla, J. M. ; Garcia de la Villa, B. ; Sahuquillo, A. ; Bravo Marques, R. ; Torres Calvo, F. ; Perez-Martinez, M. T. ; Gracia-Rodenas, M. R. ; Garrido-Bravo, I. P. ; Pastor-Perez, F. ; Pascual-Figal, D. A. ; Diaz Molina, B. ; Orus, J. ; Epelde Gonzalo, F. ; Bertomeu, V. ; Valero, R. ; Martinez-Abellan, R. ; Quiles, J. ; Rodrigez-Ortega, J. A. ; Mateo, I. ; ElAmrani, A. ; Fernandez-Vivancos, C. ; Bierge Valero, D. ; Almenar-Bonet, L. ; Sanchez-Lazaro, I. J. ; Marques-Sule, E. ; Facila-Rubio, L. ; Perez-Silvestre, J. ; Garcia-Gonzalez, P. ; Ridocci-Soriano, F. ; Garcia-Escriva, D. ; Pellicer-Cabo, A. ; de la Fuente Galan, L. ; Lopez Diaz, J. ; Recio Platero, A. ; Arias, J. C. ; Blasco-Peiro, T. ; Sanz Julve, M. ; Sanchez-Insa, E. ; Aured-Guallar, C. ; Portoles-Ocampo, A. ; Melin, M. ; Hägglund, E. ; Stenberg, A. ; Lindahl, I. M. ; Asserlund, B. ; Olsson, L. ; Afzelius, M. ; Karlström, P. ; Tengvall, L. ; Wiklund, P. A. ; Olsson, B. ; Kalayci, S. ; Cavusoglu, Y. ; Gencer, E. ; Yilmaz, M. B. ; Gunes, H. / Performance of Prognostic Risk Scores in Chronic Heart Failure Patients Enrolled in the European Society of Cardiology Heart Failure Long-Term Registry. In: JACC: Heart Failure. 2018 ; Vol. 6, No. 6. pp. 452-462.
@article{c052e6804b68408db3601615fba2448a,
title = "Performance of Prognostic Risk Scores in Chronic Heart Failure Patients Enrolled in the European Society of Cardiology Heart Failure Long-Term Registry",
abstract = "Objectives: This study compared the performance of major heart failure (HF) risk models in predicting mortality and examined their utilization using data from a contemporary multinational registry. Background: Several prognostic risk scores have been developed for ambulatory HF patients, but their precision is still inadequate and their use limited. Methods: This registry enrolled patients with HF seen in participating European centers between May 2011 and April 2013. The following scores designed to estimate 1- to 2-year all-cause mortality were calculated in each participant: CHARM (Candesartan in Heart Failure-Assessment of Reduction in Mortality), GISSI-HF (Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico-Heart Failure), MAGGIC (Meta-analysis Global Group in Chronic Heart Failure), and SHFM (Seattle Heart Failure Model). Patients with hospitalized HF (n = 6,920) and ambulatory HF patients missing any variable needed to estimate each score (n = 3,267) were excluded, leaving a final sample of 6,161 patients. Results: At 1-year follow-up, 5,653 of 6,161 patients (91.8{\%}) were alive. The observed-to-predicted survival ratios (CHARM: 1.10, GISSI-HF: 1.08, MAGGIC: 1.03, and SHFM: 0.98) suggested some overestimation of mortality by all scores except the SHFM. Overprediction occurred steadily across levels of risk using both the CHARM and the GISSI-HF, whereas the SHFM underpredicted mortality in all risk groups except the highest. The MAGGIC showed the best overall accuracy (area under the curve [AUC] = 0.743), similar to the GISSI-HF (AUC = 0.739; p = 0.419) but better than the CHARM (AUC = 0.729; p = 0.068) and particularly better than the SHFM (AUC = 0.714; p = 0.018). Less than 1{\%} of patients received a prognostic estimate from their enrolling physician. Conclusions: Performance of prognostic risk scores is still limited and physicians are reluctant to use them in daily practice. The need for contemporary, more precise prognostic tools should be considered.",
keywords = "heart failure, mortality, prognosis, risk score",
author = "Marco Canepa and Candida Fonseca and O. Chioncel and C{\'e}cile Laroche and M. Crespo-Leiro and Coats, {Andrew J.S.} and A. Mebazaa and Piepoli, {M. F.} and Luigi Tavazzi and Maggioni, {A. P.} and M. Crespo-Leiro and S. Anker and A. Mebazaa and A. Coats and G. Filippatos and R. Ferrari and Maggioni, {A. P.} and Piepoli, {M. F.} and O. Amir and O. Chioncel and U. Dahlstr{\"o}m and {Delgado Jimenez}, {J. F.} and J. Drozdz and A. Erglis and E. Fazlibegovic and C. Fonseca and F. Fruhwald and P. Gatzov and E. Goncalvesova and M. Hassanein and J. Hradec and A. Kavoliuniene and M. Lainscak and D. Logeart and B. Merkely and M. Metra and M. Otljanska and Seferovic, {P. M.} and {Srbinovska Kostovska}, E. and A. Temizhan and D. Tousoulis and T. Ferreira and M. Andarala and E. Fiorucci and {Folkesson Lefrancq}, E. and M. Gl{\'e}mot and G. Gracia and M. Konte and C. Laroche and McNeill, {P. A.} and V. Missiamenou and C. Taylor and J. Auer and K. Ablasser and T. Dolze and K. Brandner and S. Gstrein and G. Poelzl and D. Moertl and S. Reiter and A. Podczeck-Schweighofer and A. Muslibegovic and M. Vasilj and M. Cesko and D. Zelenika and B. Palic and D. Pravdic and D. Cuk and K. Vitlianova and T. Katova and T. Velikov and T. Kurteva and D. Kamenova and M. Antova and V. Sirakova and J. Krejci and M. Mikolaskova and J. Spinar and J. Krupicka and F. Malek and M. Hegarova and M. Lazarova and Z. Monhart and M. Sobhy and {El Messiry}, F. and {El Shazly}, {A. H.} and Y. Elrakshy and A. Youssef and Moneim, {A. A.} and M. Noamany and A. Reda and {Abdel Dayem}, {T. K.} and N. Farag and {Ibrahim Halawa}, S. and {Abdel Hamid}, M. and K. Said and A. Saleh and H. Ebeid and R. Hanna and R. Aziz and O. Louis and Enen, {M. A.} and Ibrahim, {B. S.} and G. Nasr and A. Elbahry and H. Sobhy and M. Ashmawy and M. Gouda and W. Aboleineen and Y. Bernard and P. Luporsi and N. Meneveau and M. Pillot and M. Morel and Seronde, {M. F.} and F. Schiele and F. Briand and F. Delahaye and T. Damy and Eicher, {J. C.} and {de Groote}, P. and M. Fertin and N. Lamblin and R. Isnard and C. Lefol and S. Thevenin and A. Hagege and G. Jondeau and {Le Marcis}, V. and Ly, {J. F.} and D. Coisne and B. Lequeux and {Le Moal}, V. and S. Mascle and P. Lotton and N. Behar and E. Donal and C. Thebault and C. Ridard and A. Reynaud and A. Basquin and F. Bauer and R. Codjia and M. Galinier and P. Tourikis and M. Stavroula and C. Stefanadis and C. Chrysohoou and I. Kotrogiannis and V. Matzaraki and T. Dimitroula and A. Karavidas and G. Tsitsinakis and C. Kapelios and J. Nanas and H. Kampouri and E. Nana and E. Kaldara and A. Eugenidou and P. Vardas and I. Saloustros and A. Patrianakos and T. Tsaknakis and S. Evangelou and N. Nikoloulis and H. Tziourganou and A. Tsaroucha and A. Papadopoulou and A. Douras and L. Polgar and A. Kosztin and N. Nyolczas and {Csaba Nagy}, A. and R. Halmosi and J. Elber and I. Alony and A. Shotan and {Vazan Fuhrmann}, A. and S. Romano and S. Marcon and M. Penco and {Di Mauro}, M. and E. Lemme and V. Carubelli and R. Rovetta and M. Bulgari and F. Quinzani and C. Lombardi and S. Bosi and G. Schiavina and A. Squeri and A. Barbieri and {Di Tano}, G. and S. Pirelli and A. Fucili and T. Passero and S. Musio and {Di Biase}, M. and M. Correale and G. Salvemini and S. Brognoli and E. Zanelli and A. Giordano and P. Agostoni and G. Italiano and E. Salvioni and S. Copelli and Modena, {M. G.} and L. Reggianini and C. Valenti and A. Olaru and S. Bandino and M. Deidda and G. Mercuro and {Cadeddu Dessalvi}, C. and Marino, {P. N.} and {Di Ruocco}, {M. V.} and C. Sartori and C. Piccinino and G. Parrinello and G. Licata and D. Torres and S. Giambanco and S. Busalacchi and S. Arrotti and S. Novo and Inciardi, {R. M.} and P. Pieri and Chirco, {P. R.} and {Ausilia Galifi}, M. and G. Teresi and D. Buccheri and A. Minacapelli and M. Veniani and A. Frisinghelli and Priori, {S. G.} and S. Cattaneo and C. Opasich and A. Gualco and M. Pagliaro and M. Mancone and F. Fedele and A. Cinque and M. Vellini and I. Scarfo and F. Romeo and F. Ferraiuolo and D. Sergi and M. Anselmi and F. Melandri and E. Leci and E. Iori and V. Bovolo and S. Pidello and S. Frea and S. Bergerone and M. Botta and Canavosio, {F. G.} and F. Gaita and M. Merlo and M. Cinquetti and G. Sinagra and F. Ramani and E. Fabris and D. Stolfo and J. Artico and D. Miani and C. Fresco and C. Daneluzzi and A. Proclemer and M. Cicoira and L. Zanolla and G. Marchese and F. Torelli and C. Vassanelli and N. Voronina and V. Tamakauskas and V. Smalinskas and R. Karaliute and I. Petraskiene and E. Kazakauskaite and E. Rumbinaite and V. Vysniauskas and R. Brazyte-Ramanauskiene and D. Petraskiene and S. Stankala and P. Switala and Z. Juszczyk and W. Sinkiewicz and W. Gilewski and J. Pietrzak and T. Orzel and P. Kasztelowicz and P. Kardaszewicz and M. Lazorko-Piega and J. Gabryel and K. Mosakowska and J. Bellwon and A. Rynkiewicz and G. Raczak and E. Lewicka and A. Dabrowska-Kugacka and R. Bartkowiak and B. Sosnowska-Pasiarska and B. Wozakowska-Kaplon and A. Krzeminski and M. Zabojszcz and E. Mirek-Bryniarska and A. Grzegorzko and K. Bury and J. Nessler and J. Zalewski and A. Furman and M. Broncel and A. Poliwczak and A. Bala and P. Zycinski and M. Rudzinska and L. Jankowski and Kasprzak, {J. D.} and L. Michalak and {Wojtczak Soska}, K. and I. Huziuk and A. Retwinski and P. Flis and J. Weglarz and A. Bodys and S. Grajek and M. Kaluzna-Oleksy and E. Straburzynska-Migaj and R. Dankowski and K. Szymanowska and J. Grabia and A. Szyszka and A. Nowicka and M. Samcik and L. Wolniewicz and K. Baczynska and K. Komorowska and I. Poprawa and E. Komorowska and D. Sajnaga and A. Zolbach and A. Dudzik-Plocica and Abdulkarim, {A. F.} and A. Lauko-Rachocka and L. Kaminski and A. Kostka and A. Cichy and P. Ruszkowski and M. Splawski and G. Fitas and A. Szymczyk and A. Serwicka and A. Fiega and D. Zysko and W. Krysiak and S. Szabowski and E. Skorek and P. Pruszczyk and P. Bienias and M. Ciurzynski and M. Welnicki and A. Mamcarz and A. Folga and T. Zielinski and T. Rywik and P. Leszek and M. Sobieszczanska-Malek and M. Piotrowska and K. Kozar-Kaminska and K. Komuda and J. Wisniewska and A. Tarnowska and P. Balsam and M. Marchel and G. Opolski and A. Kaplon-Cieslicka and Gil, {R. J.} and O. Mozenska and K. Byczkowska and K. Gil and A. Pawlak and A. Michalek and P. Krzesinski and K. Piotrowicz and B. Uzieblo-Zyczkowska and A. Stanczyk and A. Skrobowski and P. Ponikowski and E. Jankowska and P. Rozentryt and L. Polonski and E. Gadula-Gacek and E. Nowalany-Kozielska and A. Kuczaj and Z. Kalarus and M. Szulik and K. Przybylska and J. Klys and G. Prokop-Lewicka and A. Kleinrok and {Tavares Aguiar}, C. and A. Ventosa and S. Pereira and R. Faria and J. Chin and {De Jesus}, I. and R. Santos and P. Silva and N. Moreno and C. Queir{\'o}s and C. Louren{\cc}o and A. Pereira and A. Castro and A. Andrade and {Oliveira Guimaraes}, T. and S. Martins and R. Placido and G. Lima and D. Brito and Francisco, {A. R.} and R. Cardiga and M. Proenca and I. Araujo and F. Marques and B. Moura and S. Leite and M. Campelo and J. Silva-Cardoso and J. Rodrigues and I. Rangel and E. Martins and {Sofia Correia}, A. and M. Peres and L. Marta and {Ferreira da Silva}, G. and D. Severino and D. Durao and S. Leao and P. Magalhaes and I. Moreira and {Filipa Cordeiro}, A. and C. Ferreira and C. Araujo and A. Ferreira and A. Baptista and M. Radoi and G. Bicescu and D. Vinereanu and Sinescu, {C. J.} and C. Macarie and R. Popescu and I. Daha and Dan, {G. A.} and C. Stanescu and A. Dan and E. Craiu and E. Nechita and V. Aursulesei and R. Christodorescu and P. Otasevic and D. Simeunovic and Ristic, {A. D.} and V. Celic and M. Pavlovic-Kleut and {Suzic Lazic}, J. and B. Stojcevski and B. Pencic and A. Stevanovic and A. Andric and V. Iric-Cupic and M. Jovic and G. Davidovic and S. Milanov and V. Mitic and V. Atanaskovic and S. Antic and M. Pavlovic and D. Stanojevic and V. Stoickov and S. Ilic and {Deljanin Ilic}, M. and D. Petrovic and S. Stojsic and S. Kecojevic and S. Dodic and {Cemerlic Adic}, N. and M. Cankovic and J. Stojiljkovic and B. Mihajlovic and A. Radin and S. Radovanovic and M. Krotin and A. Klabnik and M. Pernicky and J. Murin and F. Kovar and J. Kmec and H. Semjanova and M. Strasek and {Savnik Iskra}, M. and T. Ravnikar and {Cernic Suligoj}, N. and J. Komel and Z. Fras and B. Jug and T. Glavic and R. Losic and M. Bombek and I. Krajnc and B. Krunic and S. Horvat and D. Kovac and D. Rajtman and V. Cencic and M. Letonja and R. Winkler and M. Valentincic and C. Melihen-Bartolic and A. Bartolic and {Pusnik Vrckovnik}, M. and M. Kladnik and {Slemenik Pusnik}, C. and A. Marolt and J. Klen and B. Drnovsek and B. Leskovar and {Fernandez Anguita}, {M. J.} and {Gallego Page}, {J. C.} and {Salmeron Martinez}, {F. M.} and J. Andres and Genis, {A. B.} and S. Mirabet and A. Mendez and L. Garcia-Cosio and E. Roig and V. Leon and J. Gonzalez-Costello and G. Muntane and A. Garay and V. Alcade-Martinez and {Lopez Fernandez}, S. and R. Rivera-Lopez and M. Puga-Martinez and M. Fernandez-Alvarez and Serrano-Martinez, {J. L.} and Z. Grille-Cancela and R. Marzoa-Rivas and P. Blanco-Canosa and Paniagua-Martin, {M. J.} and E. Barge-Caballero and {Laynez Cerdena}, I. and {Famara Hernandez Baldomero}, I. and {Lara Padron}, A. and {Ofelia Rosillo}, S. and {Dalmau Gonzalez-Gallarza}, R. and {Salvador Montanes}, O. and {Iniesta Manjavacas}, {A. M.} and {Castro Conde}, A. and A. Araujo and T. Soria and P. Garcia-Pavia and M. Gomez-Bueno and M. Cobo-Marcos and L. Alonso-Pulpon and {Segovia Cubero}, J. and I. Sayago and A. Gonzalez-Segovia and A. Briceno and {Escribano Subias}, P. and {Vicente Hernandez}, M. and {Ruiz Cano}, {M. J.} and {Gomez Sanchez}, {M. A.} and {Barrios Garrido-Lestache}, E. and {Garcia Pinilla}, {J. M.} and {Garcia de la Villa}, B. and A. Sahuquillo and {Bravo Marques}, R. and {Torres Calvo}, F. and Perez-Martinez, {M. T.} and Gracia-Rodenas, {M. R.} and Garrido-Bravo, {I. P.} and F. Pastor-Perez and Pascual-Figal, {D. A.} and {Diaz Molina}, B. and J. Orus and {Epelde Gonzalo}, F. and V. Bertomeu and R. Valero and R. Martinez-Abellan and J. Quiles and Rodrigez-Ortega, {J. A.} and I. Mateo and A. ElAmrani and C. Fernandez-Vivancos and {Bierge Valero}, D. and L. Almenar-Bonet and Sanchez-Lazaro, {I. J.} and E. Marques-Sule and L. Facila-Rubio and J. Perez-Silvestre and P. Garcia-Gonzalez and F. Ridocci-Soriano and D. Garcia-Escriva and A. Pellicer-Cabo and {de la Fuente Galan}, L. and {Lopez Diaz}, J. and {Recio Platero}, A. and Arias, {J. C.} and T. Blasco-Peiro and {Sanz Julve}, M. and E. Sanchez-Insa and C. Aured-Guallar and A. Portoles-Ocampo and M. Melin and E. H{\"a}gglund and A. Stenberg and Lindahl, {I. M.} and B. Asserlund and L. Olsson and M. Afzelius and P. Karlstr{\"o}m and L. Tengvall and Wiklund, {P. A.} and B. Olsson and S. Kalayci and Y. Cavusoglu and E. Gencer and Yilmaz, {M. B.} and H. Gunes",
year = "2018",
month = "6",
day = "1",
doi = "10.1016/j.jchf.2018.02.001",
language = "English",
volume = "6",
pages = "452--462",
journal = "JACC: Heart Failure",
issn = "2213-1779",
publisher = "Elsevier",
number = "6",

}

Canepa, M, Fonseca, C, Chioncel, O, Laroche, C, Crespo-Leiro, M, Coats, AJS, Mebazaa, A, Piepoli, MF, Tavazzi, L, Maggioni, AP, Crespo-Leiro, M, Anker, S, Mebazaa, A, Coats, A, Filippatos, G, Ferrari, R, Maggioni, AP, Piepoli, MF, Amir, O, Chioncel, O, Dahlström, U, Delgado Jimenez, JF, Drozdz, J, Erglis, A, Fazlibegovic, E, Fonseca, C, Fruhwald, F, Gatzov, P, Goncalvesova, E, Hassanein, M, Hradec, J, Kavoliuniene, A, Lainscak, M, Logeart, D, Merkely, B, Metra, M, Otljanska, M, Seferovic, PM, Srbinovska Kostovska, E, Temizhan, A, Tousoulis, D, Ferreira, T, Andarala, M, Fiorucci, E, Folkesson Lefrancq, E, Glémot, M, Gracia, G, Konte, M, Laroche, C, McNeill, PA, Missiamenou, V, Taylor, C, Auer, J, Ablasser, K, Dolze, T, Brandner, K, Gstrein, S, Poelzl, G, Moertl, D, Reiter, S, Podczeck-Schweighofer, A, Muslibegovic, A, Vasilj, M, Cesko, M, Zelenika, D, Palic, B, Pravdic, D, Cuk, D, Vitlianova, K, Katova, T, Velikov, T, Kurteva, T, Kamenova, D, Antova, M, Sirakova, V, Krejci, J, Mikolaskova, M, Spinar, J, Krupicka, J, Malek, F, Hegarova, M, Lazarova, M, Monhart, Z, Sobhy, M, El Messiry, F, El Shazly, AH, Elrakshy, Y, Youssef, A, Moneim, AA, Noamany, M, Reda, A, Abdel Dayem, TK, Farag, N, Ibrahim Halawa, S, Abdel Hamid, M, Said, K, Saleh, A, Ebeid, H, Hanna, R, Aziz, R, Louis, O, Enen, MA, Ibrahim, BS, Nasr, G, Elbahry, A, Sobhy, H, Ashmawy, M, Gouda, M, Aboleineen, W, Bernard, Y, Luporsi, P, Meneveau, N, Pillot, M, Morel, M, Seronde, MF, Schiele, F, Briand, F, Delahaye, F, Damy, T, Eicher, JC, de Groote, P, Fertin, M, Lamblin, N, Isnard, R, Lefol, C, Thevenin, S, Hagege, A, Jondeau, G, Le Marcis, V, Ly, JF, Coisne, D, Lequeux, B, Le Moal, V, Mascle, S, Lotton, P, Behar, N, Donal, E, Thebault, C, Ridard, C, Reynaud, A, Basquin, A, Bauer, F, Codjia, R, Galinier, M, Tourikis, P, Stavroula, M, Stefanadis, C, Chrysohoou, C, Kotrogiannis, I, Matzaraki, V, Dimitroula, T, Karavidas, A, Tsitsinakis, G, Kapelios, C, Nanas, J, Kampouri, H, Nana, E, Kaldara, E, Eugenidou, A, Vardas, P, Saloustros, I, Patrianakos, A, Tsaknakis, T, Evangelou, S, Nikoloulis, N, Tziourganou, H, Tsaroucha, A, Papadopoulou, A, Douras, A, Polgar, L, Kosztin, A, Nyolczas, N, Csaba Nagy, A, Halmosi, R, Elber, J, Alony, I, Shotan, A, Vazan Fuhrmann, A, Romano, S, Marcon, S, Penco, M, Di Mauro, M, Lemme, E, Carubelli, V, Rovetta, R, Bulgari, M, Quinzani, F, Lombardi, C, Bosi, S, Schiavina, G, Squeri, A, Barbieri, A, Di Tano, G, Pirelli, S, Fucili, A, Passero, T, Musio, S, Di Biase, M, Correale, M, Salvemini, G, Brognoli, S, Zanelli, E, Giordano, A, Agostoni, P, Italiano, G, Salvioni, E, Copelli, S, Modena, MG, Reggianini, L, Valenti, C, Olaru, A, Bandino, S, Deidda, M, Mercuro, G, Cadeddu Dessalvi, C, Marino, PN, Di Ruocco, MV, Sartori, C, Piccinino, C, Parrinello, G, Licata, G, Torres, D, Giambanco, S, Busalacchi, S, Arrotti, S, Novo, S, Inciardi, RM, Pieri, P, Chirco, PR, Ausilia Galifi, M, Teresi, G, Buccheri, D, Minacapelli, A, Veniani, M, Frisinghelli, A, Priori, SG, Cattaneo, S, Opasich, C, Gualco, A, Pagliaro, M, Mancone, M, Fedele, F, Cinque, A, Vellini, M, Scarfo, I, Romeo, F, Ferraiuolo, F, Sergi, D, Anselmi, M, Melandri, F, Leci, E, Iori, E, Bovolo, V, Pidello, S, Frea, S, Bergerone, S, Botta, M, Canavosio, FG, Gaita, F, Merlo, M, Cinquetti, M, Sinagra, G, Ramani, F, Fabris, E, Stolfo, D, Artico, J, Miani, D, Fresco, C, Daneluzzi, C, Proclemer, A, Cicoira, M, Zanolla, L, Marchese, G, Torelli, F, Vassanelli, C, Voronina, N, Tamakauskas, V, Smalinskas, V, Karaliute, R, Petraskiene, I, Kazakauskaite, E, Rumbinaite, E, Vysniauskas, V, Brazyte-Ramanauskiene, R, Petraskiene, D, Stankala, S, Switala, P, Juszczyk, Z, Sinkiewicz, W, Gilewski, W, Pietrzak, J, Orzel, T, Kasztelowicz, P, Kardaszewicz, P, Lazorko-Piega, M, Gabryel, J, Mosakowska, K, Bellwon, J, Rynkiewicz, A, Raczak, G, Lewicka, E, Dabrowska-Kugacka, A, Bartkowiak, R, Sosnowska-Pasiarska, B, Wozakowska-Kaplon, B, Krzeminski, A, Zabojszcz, M, Mirek-Bryniarska, E, Grzegorzko, A, Bury, K, Nessler, J, Zalewski, J, Furman, A, Broncel, M, Poliwczak, A, Bala, A, Zycinski, P, Rudzinska, M, Jankowski, L, Kasprzak, JD, Michalak, L, Wojtczak Soska, K, Huziuk, I, Retwinski, A, Flis, P, Weglarz, J, Bodys, A, Grajek, S, Kaluzna-Oleksy, M, Straburzynska-Migaj, E, Dankowski, R, Szymanowska, K, Grabia, J, Szyszka, A, Nowicka, A, Samcik, M, Wolniewicz, L, Baczynska, K, Komorowska, K, Poprawa, I, Komorowska, E, Sajnaga, D, Zolbach, A, Dudzik-Plocica, A, Abdulkarim, AF, Lauko-Rachocka, A, Kaminski, L, Kostka, A, Cichy, A, Ruszkowski, P, Splawski, M, Fitas, G, Szymczyk, A, Serwicka, A, Fiega, A, Zysko, D, Krysiak, W, Szabowski, S, Skorek, E, Pruszczyk, P, Bienias, P, Ciurzynski, M, Welnicki, M, Mamcarz, A, Folga, A, Zielinski, T, Rywik, T, Leszek, P, Sobieszczanska-Malek, M, Piotrowska, M, Kozar-Kaminska, K, Komuda, K, Wisniewska, J, Tarnowska, A, Balsam, P, Marchel, M, Opolski, G, Kaplon-Cieslicka, A, Gil, RJ, Mozenska, O, Byczkowska, K, Gil, K, Pawlak, A, Michalek, A, Krzesinski, P, Piotrowicz, K, Uzieblo-Zyczkowska, B, Stanczyk, A, Skrobowski, A, Ponikowski, P, Jankowska, E, Rozentryt, P, Polonski, L, Gadula-Gacek, E, Nowalany-Kozielska, E, Kuczaj, A, Kalarus, Z, Szulik, M, Przybylska, K, Klys, J, Prokop-Lewicka, G, Kleinrok, A, Tavares Aguiar, C, Ventosa, A, Pereira, S, Faria, R, Chin, J, De Jesus, I, Santos, R, Silva, P, Moreno, N, Queirós, C, Lourenço, C, Pereira, A, Castro, A, Andrade, A, Oliveira Guimaraes, T, Martins, S, Placido, R, Lima, G, Brito, D, Francisco, AR, Cardiga, R, Proenca, M, Araujo, I, Marques, F, Moura, B, Leite, S, Campelo, M, Silva-Cardoso, J, Rodrigues, J, Rangel, I, Martins, E, Sofia Correia, A, Peres, M, Marta, L, Ferreira da Silva, G, Severino, D, Durao, D, Leao, S, Magalhaes, P, Moreira, I, Filipa Cordeiro, A, Ferreira, C, Araujo, C, Ferreira, A, Baptista, A, Radoi, M, Bicescu, G, Vinereanu, D, Sinescu, CJ, Macarie, C, Popescu, R, Daha, I, Dan, GA, Stanescu, C, Dan, A, Craiu, E, Nechita, E, Aursulesei, V, Christodorescu, R, Otasevic, P, Simeunovic, D, Ristic, AD, Celic, V, Pavlovic-Kleut, M, Suzic Lazic, J, Stojcevski, B, Pencic, B, Stevanovic, A, Andric, A, Iric-Cupic, V, Jovic, M, Davidovic, G, Milanov, S, Mitic, V, Atanaskovic, V, Antic, S, Pavlovic, M, Stanojevic, D, Stoickov, V, Ilic, S, Deljanin Ilic, M, Petrovic, D, Stojsic, S, Kecojevic, S, Dodic, S, Cemerlic Adic, N, Cankovic, M, Stojiljkovic, J, Mihajlovic, B, Radin, A, Radovanovic, S, Krotin, M, Klabnik, A, Pernicky, M, Murin, J, Kovar, F, Kmec, J, Semjanova, H, Strasek, M, Savnik Iskra, M, Ravnikar, T, Cernic Suligoj, N, Komel, J, Fras, Z, Jug, B, Glavic, T, Losic, R, Bombek, M, Krajnc, I, Krunic, B, Horvat, S, Kovac, D, Rajtman, D, Cencic, V, Letonja, M, Winkler, R, Valentincic, M, Melihen-Bartolic, C, Bartolic, A, Pusnik Vrckovnik, M, Kladnik, M, Slemenik Pusnik, C, Marolt, A, Klen, J, Drnovsek, B, Leskovar, B, Fernandez Anguita, MJ, Gallego Page, JC, Salmeron Martinez, FM, Andres, J, Genis, AB, Mirabet, S, Mendez, A, Garcia-Cosio, L, Roig, E, Leon, V, Gonzalez-Costello, J, Muntane, G, Garay, A, Alcade-Martinez, V, Lopez Fernandez, S, Rivera-Lopez, R, Puga-Martinez, M, Fernandez-Alvarez, M, Serrano-Martinez, JL, Grille-Cancela, Z, Marzoa-Rivas, R, Blanco-Canosa, P, Paniagua-Martin, MJ, Barge-Caballero, E, Laynez Cerdena, I, Famara Hernandez Baldomero, I, Lara Padron, A, Ofelia Rosillo, S, Dalmau Gonzalez-Gallarza, R, Salvador Montanes, O, Iniesta Manjavacas, AM, Castro Conde, A, Araujo, A, Soria, T, Garcia-Pavia, P, Gomez-Bueno, M, Cobo-Marcos, M, Alonso-Pulpon, L, Segovia Cubero, J, Sayago, I, Gonzalez-Segovia, A, Briceno, A, Escribano Subias, P, Vicente Hernandez, M, Ruiz Cano, MJ, Gomez Sanchez, MA, Barrios Garrido-Lestache, E, Garcia Pinilla, JM, Garcia de la Villa, B, Sahuquillo, A, Bravo Marques, R, Torres Calvo, F, Perez-Martinez, MT, Gracia-Rodenas, MR, Garrido-Bravo, IP, Pastor-Perez, F, Pascual-Figal, DA, Diaz Molina, B, Orus, J, Epelde Gonzalo, F, Bertomeu, V, Valero, R, Martinez-Abellan, R, Quiles, J, Rodrigez-Ortega, JA, Mateo, I, ElAmrani, A, Fernandez-Vivancos, C, Bierge Valero, D, Almenar-Bonet, L, Sanchez-Lazaro, IJ, Marques-Sule, E, Facila-Rubio, L, Perez-Silvestre, J, Garcia-Gonzalez, P, Ridocci-Soriano, F, Garcia-Escriva, D, Pellicer-Cabo, A, de la Fuente Galan, L, Lopez Diaz, J, Recio Platero, A, Arias, JC, Blasco-Peiro, T, Sanz Julve, M, Sanchez-Insa, E, Aured-Guallar, C, Portoles-Ocampo, A, Melin, M, Hägglund, E, Stenberg, A, Lindahl, IM, Asserlund, B, Olsson, L, Afzelius, M, Karlström, P, Tengvall, L, Wiklund, PA, Olsson, B, Kalayci, S, Cavusoglu, Y, Gencer, E, Yilmaz, MB & Gunes, H 2018, 'Performance of Prognostic Risk Scores in Chronic Heart Failure Patients Enrolled in the European Society of Cardiology Heart Failure Long-Term Registry', JACC: Heart Failure, vol. 6, no. 6, pp. 452-462. https://doi.org/10.1016/j.jchf.2018.02.001

Performance of Prognostic Risk Scores in Chronic Heart Failure Patients Enrolled in the European Society of Cardiology Heart Failure Long-Term Registry. / Canepa, Marco; Fonseca, Candida; Chioncel, O.; Laroche, Cécile; Crespo-Leiro, M.; Coats, Andrew J.S.; Mebazaa, A.; Piepoli, M. F.; Tavazzi, Luigi; Maggioni, A. P.; Crespo-Leiro, M.; Anker, S.; Mebazaa, A.; Coats, A.; Filippatos, G.; Ferrari, R.; Maggioni, A. P.; Piepoli, M. F.; Amir, O.; Chioncel, O.; Dahlström, U.; Delgado Jimenez, J. F.; Drozdz, J.; Erglis, A.; Fazlibegovic, E.; Fonseca, C.; Fruhwald, F.; Gatzov, P.; Goncalvesova, E.; Hassanein, M.; Hradec, J.; Kavoliuniene, A.; Lainscak, M.; Logeart, D.; Merkely, B.; Metra, M.; Otljanska, M.; Seferovic, P. M.; Srbinovska Kostovska, E.; Temizhan, A.; Tousoulis, D.; Ferreira, T.; Andarala, M.; Fiorucci, E.; Folkesson Lefrancq, E.; Glémot, M.; Gracia, G.; Konte, M.; Laroche, C.; McNeill, P. A.; Missiamenou, V.; Taylor, C.; Auer, J.; Ablasser, K.; Dolze, T.; Brandner, K.; Gstrein, S.; Poelzl, G.; Moertl, D.; Reiter, S.; Podczeck-Schweighofer, A.; Muslibegovic, A.; Vasilj, M.; Cesko, M.; Zelenika, D.; Palic, B.; Pravdic, D.; Cuk, D.; Vitlianova, K.; Katova, T.; Velikov, T.; Kurteva, T.; Kamenova, D.; Antova, M.; Sirakova, V.; Krejci, J.; Mikolaskova, M.; Spinar, J.; Krupicka, J.; Malek, F.; Hegarova, M.; Lazarova, M.; Monhart, Z.; Sobhy, M.; El Messiry, F.; El Shazly, A. H.; Elrakshy, Y.; Youssef, A.; Moneim, A. A.; Noamany, M.; Reda, A.; Abdel Dayem, T. K.; Farag, N.; Ibrahim Halawa, S.; Abdel Hamid, M.; Said, K.; Saleh, A.; Ebeid, H.; Hanna, R.; Aziz, R.; Louis, O.; Enen, M. A.; Ibrahim, B. S.; Nasr, G.; Elbahry, A.; Sobhy, H.; Ashmawy, M.; Gouda, M.; Aboleineen, W.; Bernard, Y.; Luporsi, P.; Meneveau, N.; Pillot, M.; Morel, M.; Seronde, M. F.; Schiele, F.; Briand, F.; Delahaye, F.; Damy, T.; Eicher, J. C.; de Groote, P.; Fertin, M.; Lamblin, N.; Isnard, R.; Lefol, C.; Thevenin, S.; Hagege, A.; Jondeau, G.; Le Marcis, V.; Ly, J. F.; Coisne, D.; Lequeux, B.; Le Moal, V.; Mascle, S.; Lotton, P.; Behar, N.; Donal, E.; Thebault, C.; Ridard, C.; Reynaud, A.; Basquin, A.; Bauer, F.; Codjia, R.; Galinier, M.; Tourikis, P.; Stavroula, M.; Stefanadis, C.; Chrysohoou, C.; Kotrogiannis, I.; Matzaraki, V.; Dimitroula, T.; Karavidas, A.; Tsitsinakis, G.; Kapelios, C.; Nanas, J.; Kampouri, H.; Nana, E.; Kaldara, E.; Eugenidou, A.; Vardas, P.; Saloustros, I.; Patrianakos, A.; Tsaknakis, T.; Evangelou, S.; Nikoloulis, N.; Tziourganou, H.; Tsaroucha, A.; Papadopoulou, A.; Douras, A.; Polgar, L.; Kosztin, A.; Nyolczas, N.; Csaba Nagy, A.; Halmosi, R.; Elber, J.; Alony, I.; Shotan, A.; Vazan Fuhrmann, A.; Romano, S.; Marcon, S.; Penco, M.; Di Mauro, M.; Lemme, E.; Carubelli, V.; Rovetta, R.; Bulgari, M.; Quinzani, F.; Lombardi, C.; Bosi, S.; Schiavina, G.; Squeri, A.; Barbieri, A.; Di Tano, G.; Pirelli, S.; Fucili, A.; Passero, T.; Musio, S.; Di Biase, M.; Correale, M.; Salvemini, G.; Brognoli, S.; Zanelli, E.; Giordano, A.; Agostoni, P.; Italiano, G.; Salvioni, E.; Copelli, S.; Modena, M. G.; Reggianini, L.; Valenti, C.; Olaru, A.; Bandino, S.; Deidda, M.; Mercuro, G.; Cadeddu Dessalvi, C.; Marino, P. N.; Di Ruocco, M. V.; Sartori, C.; Piccinino, C.; Parrinello, G.; Licata, G.; Torres, D.; Giambanco, S.; Busalacchi, S.; Arrotti, S.; Novo, S.; Inciardi, R. M.; Pieri, P.; Chirco, P. R.; Ausilia Galifi, M.; Teresi, G.; Buccheri, D.; Minacapelli, A.; Veniani, M.; Frisinghelli, A.; Priori, S. G.; Cattaneo, S.; Opasich, C.; Gualco, A.; Pagliaro, M.; Mancone, M.; Fedele, F.; Cinque, A.; Vellini, M.; Scarfo, I.; Romeo, F.; Ferraiuolo, F.; Sergi, D.; Anselmi, M.; Melandri, F.; Leci, E.; Iori, E.; Bovolo, V.; Pidello, S.; Frea, S.; Bergerone, S.; Botta, M.; Canavosio, F. G.; Gaita, F.; Merlo, M.; Cinquetti, M.; Sinagra, G.; Ramani, F.; Fabris, E.; Stolfo, D.; Artico, J.; Miani, D.; Fresco, C.; Daneluzzi, C.; Proclemer, A.; Cicoira, M.; Zanolla, L.; Marchese, G.; Torelli, F.; Vassanelli, C.; Voronina, N.; Tamakauskas, V.; Smalinskas, V.; Karaliute, R.; Petraskiene, I.; Kazakauskaite, E.; Rumbinaite, E.; Vysniauskas, V.; Brazyte-Ramanauskiene, R.; Petraskiene, D.; Stankala, S.; Switala, P.; Juszczyk, Z.; Sinkiewicz, W.; Gilewski, W.; Pietrzak, J.; Orzel, T.; Kasztelowicz, P.; Kardaszewicz, P.; Lazorko-Piega, M.; Gabryel, J.; Mosakowska, K.; Bellwon, J.; Rynkiewicz, A.; Raczak, G.; Lewicka, E.; Dabrowska-Kugacka, A.; Bartkowiak, R.; Sosnowska-Pasiarska, B.; Wozakowska-Kaplon, B.; Krzeminski, A.; Zabojszcz, M.; Mirek-Bryniarska, E.; Grzegorzko, A.; Bury, K.; Nessler, J.; Zalewski, J.; Furman, A.; Broncel, M.; Poliwczak, A.; Bala, A.; Zycinski, P.; Rudzinska, M.; Jankowski, L.; Kasprzak, J. D.; Michalak, L.; Wojtczak Soska, K.; Huziuk, I.; Retwinski, A.; Flis, P.; Weglarz, J.; Bodys, A.; Grajek, S.; Kaluzna-Oleksy, M.; Straburzynska-Migaj, E.; Dankowski, R.; Szymanowska, K.; Grabia, J.; Szyszka, A.; Nowicka, A.; Samcik, M.; Wolniewicz, L.; Baczynska, K.; Komorowska, K.; Poprawa, I.; Komorowska, E.; Sajnaga, D.; Zolbach, A.; Dudzik-Plocica, A.; Abdulkarim, A. F.; Lauko-Rachocka, A.; Kaminski, L.; Kostka, A.; Cichy, A.; Ruszkowski, P.; Splawski, M.; Fitas, G.; Szymczyk, A.; Serwicka, A.; Fiega, A.; Zysko, D.; Krysiak, W.; Szabowski, S.; Skorek, E.; Pruszczyk, P.; Bienias, P.; Ciurzynski, M.; Welnicki, M.; Mamcarz, A.; Folga, A.; Zielinski, T.; Rywik, T.; Leszek, P.; Sobieszczanska-Malek, M.; Piotrowska, M.; Kozar-Kaminska, K.; Komuda, K.; Wisniewska, J.; Tarnowska, A.; Balsam, P.; Marchel, M.; Opolski, G.; Kaplon-Cieslicka, A.; Gil, R. J.; Mozenska, O.; Byczkowska, K.; Gil, K.; Pawlak, A.; Michalek, A.; Krzesinski, P.; Piotrowicz, K.; Uzieblo-Zyczkowska, B.; Stanczyk, A.; Skrobowski, A.; Ponikowski, P.; Jankowska, E.; Rozentryt, P.; Polonski, L.; Gadula-Gacek, E.; Nowalany-Kozielska, E.; Kuczaj, A.; Kalarus, Z.; Szulik, M.; Przybylska, K.; Klys, J.; Prokop-Lewicka, G.; Kleinrok, A.; Tavares Aguiar, C.; Ventosa, A.; Pereira, S.; Faria, R.; Chin, J.; De Jesus, I.; Santos, R.; Silva, P.; Moreno, N.; Queirós, C.; Lourenço, C.; Pereira, A.; Castro, A.; Andrade, A.; Oliveira Guimaraes, T.; Martins, S.; Placido, R.; Lima, G.; Brito, D.; Francisco, A. R.; Cardiga, R.; Proenca, M.; Araujo, I.; Marques, F.; Moura, B.; Leite, S.; Campelo, M.; Silva-Cardoso, J.; Rodrigues, J.; Rangel, I.; Martins, E.; Sofia Correia, A.; Peres, M.; Marta, L.; Ferreira da Silva, G.; Severino, D.; Durao, D.; Leao, S.; Magalhaes, P.; Moreira, I.; Filipa Cordeiro, A.; Ferreira, C.; Araujo, C.; Ferreira, A.; Baptista, A.; Radoi, M.; Bicescu, G.; Vinereanu, D.; Sinescu, C. J.; Macarie, C.; Popescu, R.; Daha, I.; Dan, G. A.; Stanescu, C.; Dan, A.; Craiu, E.; Nechita, E.; Aursulesei, V.; Christodorescu, R.; Otasevic, P.; Simeunovic, D.; Ristic, A. D.; Celic, V.; Pavlovic-Kleut, M.; Suzic Lazic, J.; Stojcevski, B.; Pencic, B.; Stevanovic, A.; Andric, A.; Iric-Cupic, V.; Jovic, M.; Davidovic, G.; Milanov, S.; Mitic, V.; Atanaskovic, V.; Antic, S.; Pavlovic, M.; Stanojevic, D.; Stoickov, V.; Ilic, S.; Deljanin Ilic, M.; Petrovic, D.; Stojsic, S.; Kecojevic, S.; Dodic, S.; Cemerlic Adic, N.; Cankovic, M.; Stojiljkovic, J.; Mihajlovic, B.; Radin, A.; Radovanovic, S.; Krotin, M.; Klabnik, A.; Pernicky, M.; Murin, J.; Kovar, F.; Kmec, J.; Semjanova, H.; Strasek, M.; Savnik Iskra, M.; Ravnikar, T.; Cernic Suligoj, N.; Komel, J.; Fras, Z.; Jug, B.; Glavic, T.; Losic, R.; Bombek, M.; Krajnc, I.; Krunic, B.; Horvat, S.; Kovac, D.; Rajtman, D.; Cencic, V.; Letonja, M.; Winkler, R.; Valentincic, M.; Melihen-Bartolic, C.; Bartolic, A.; Pusnik Vrckovnik, M.; Kladnik, M.; Slemenik Pusnik, C.; Marolt, A.; Klen, J.; Drnovsek, B.; Leskovar, B.; Fernandez Anguita, M. J.; Gallego Page, J. C.; Salmeron Martinez, F. M.; Andres, J.; Genis, A. B.; Mirabet, S.; Mendez, A.; Garcia-Cosio, L.; Roig, E.; Leon, V.; Gonzalez-Costello, J.; Muntane, G.; Garay, A.; Alcade-Martinez, V.; Lopez Fernandez, S.; Rivera-Lopez, R.; Puga-Martinez, M.; Fernandez-Alvarez, M.; Serrano-Martinez, J. L.; Grille-Cancela, Z.; Marzoa-Rivas, R.; Blanco-Canosa, P.; Paniagua-Martin, M. J.; Barge-Caballero, E.; Laynez Cerdena, I.; Famara Hernandez Baldomero, I.; Lara Padron, A.; Ofelia Rosillo, S.; Dalmau Gonzalez-Gallarza, R.; Salvador Montanes, O.; Iniesta Manjavacas, A. M.; Castro Conde, A.; Araujo, A.; Soria, T.; Garcia-Pavia, P.; Gomez-Bueno, M.; Cobo-Marcos, M.; Alonso-Pulpon, L.; Segovia Cubero, J.; Sayago, I.; Gonzalez-Segovia, A.; Briceno, A.; Escribano Subias, P.; Vicente Hernandez, M.; Ruiz Cano, M. J.; Gomez Sanchez, M. A.; Barrios Garrido-Lestache, E.; Garcia Pinilla, J. M.; Garcia de la Villa, B.; Sahuquillo, A.; Bravo Marques, R.; Torres Calvo, F.; Perez-Martinez, M. T.; Gracia-Rodenas, M. R.; Garrido-Bravo, I. P.; Pastor-Perez, F.; Pascual-Figal, D. A.; Diaz Molina, B.; Orus, J.; Epelde Gonzalo, F.; Bertomeu, V.; Valero, R.; Martinez-Abellan, R.; Quiles, J.; Rodrigez-Ortega, J. A.; Mateo, I.; ElAmrani, A.; Fernandez-Vivancos, C.; Bierge Valero, D.; Almenar-Bonet, L.; Sanchez-Lazaro, I. J.; Marques-Sule, E.; Facila-Rubio, L.; Perez-Silvestre, J.; Garcia-Gonzalez, P.; Ridocci-Soriano, F.; Garcia-Escriva, D.; Pellicer-Cabo, A.; de la Fuente Galan, L.; Lopez Diaz, J.; Recio Platero, A.; Arias, J. C.; Blasco-Peiro, T.; Sanz Julve, M.; Sanchez-Insa, E.; Aured-Guallar, C.; Portoles-Ocampo, A.; Melin, M.; Hägglund, E.; Stenberg, A.; Lindahl, I. M.; Asserlund, B.; Olsson, L.; Afzelius, M.; Karlström, P.; Tengvall, L.; Wiklund, P. A.; Olsson, B.; Kalayci, S.; Cavusoglu, Y.; Gencer, E.; Yilmaz, M. B.; Gunes, H.

In: JACC: Heart Failure, Vol. 6, No. 6, 01.06.2018, p. 452-462.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Performance of Prognostic Risk Scores in Chronic Heart Failure Patients Enrolled in the European Society of Cardiology Heart Failure Long-Term Registry

AU - Canepa, Marco

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AU - Klen, J.

AU - Drnovsek, B.

AU - Leskovar, B.

AU - Fernandez Anguita, M. J.

AU - Gallego Page, J. C.

AU - Salmeron Martinez, F. M.

AU - Andres, J.

AU - Genis, A. B.

AU - Mirabet, S.

AU - Mendez, A.

AU - Garcia-Cosio, L.

AU - Roig, E.

AU - Leon, V.

AU - Gonzalez-Costello, J.

AU - Muntane, G.

AU - Garay, A.

AU - Alcade-Martinez, V.

AU - Lopez Fernandez, S.

AU - Rivera-Lopez, R.

AU - Puga-Martinez, M.

AU - Fernandez-Alvarez, M.

AU - Serrano-Martinez, J. L.

AU - Grille-Cancela, Z.

AU - Marzoa-Rivas, R.

AU - Blanco-Canosa, P.

AU - Paniagua-Martin, M. J.

AU - Barge-Caballero, E.

AU - Laynez Cerdena, I.

AU - Famara Hernandez Baldomero, I.

AU - Lara Padron, A.

AU - Ofelia Rosillo, S.

AU - Dalmau Gonzalez-Gallarza, R.

AU - Salvador Montanes, O.

AU - Iniesta Manjavacas, A. M.

AU - Castro Conde, A.

AU - Araujo, A.

AU - Soria, T.

AU - Garcia-Pavia, P.

AU - Gomez-Bueno, M.

AU - Cobo-Marcos, M.

AU - Alonso-Pulpon, L.

AU - Segovia Cubero, J.

AU - Sayago, I.

AU - Gonzalez-Segovia, A.

AU - Briceno, A.

AU - Escribano Subias, P.

AU - Vicente Hernandez, M.

AU - Ruiz Cano, M. J.

AU - Gomez Sanchez, M. A.

AU - Barrios Garrido-Lestache, E.

AU - Garcia Pinilla, J. M.

AU - Garcia de la Villa, B.

AU - Sahuquillo, A.

AU - Bravo Marques, R.

AU - Torres Calvo, F.

AU - Perez-Martinez, M. T.

AU - Gracia-Rodenas, M. R.

AU - Garrido-Bravo, I. P.

AU - Pastor-Perez, F.

AU - Pascual-Figal, D. A.

AU - Diaz Molina, B.

AU - Orus, J.

AU - Epelde Gonzalo, F.

AU - Bertomeu, V.

AU - Valero, R.

AU - Martinez-Abellan, R.

AU - Quiles, J.

AU - Rodrigez-Ortega, J. A.

AU - Mateo, I.

AU - ElAmrani, A.

AU - Fernandez-Vivancos, C.

AU - Bierge Valero, D.

AU - Almenar-Bonet, L.

AU - Sanchez-Lazaro, I. J.

AU - Marques-Sule, E.

AU - Facila-Rubio, L.

AU - Perez-Silvestre, J.

AU - Garcia-Gonzalez, P.

AU - Ridocci-Soriano, F.

AU - Garcia-Escriva, D.

AU - Pellicer-Cabo, A.

AU - de la Fuente Galan, L.

AU - Lopez Diaz, J.

AU - Recio Platero, A.

AU - Arias, J. C.

AU - Blasco-Peiro, T.

AU - Sanz Julve, M.

AU - Sanchez-Insa, E.

AU - Aured-Guallar, C.

AU - Portoles-Ocampo, A.

AU - Melin, M.

AU - Hägglund, E.

AU - Stenberg, A.

AU - Lindahl, I. M.

AU - Asserlund, B.

AU - Olsson, L.

AU - Afzelius, M.

AU - Karlström, P.

AU - Tengvall, L.

AU - Wiklund, P. A.

AU - Olsson, B.

AU - Kalayci, S.

AU - Cavusoglu, Y.

AU - Gencer, E.

AU - Yilmaz, M. B.

AU - Gunes, H.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Objectives: This study compared the performance of major heart failure (HF) risk models in predicting mortality and examined their utilization using data from a contemporary multinational registry. Background: Several prognostic risk scores have been developed for ambulatory HF patients, but their precision is still inadequate and their use limited. Methods: This registry enrolled patients with HF seen in participating European centers between May 2011 and April 2013. The following scores designed to estimate 1- to 2-year all-cause mortality were calculated in each participant: CHARM (Candesartan in Heart Failure-Assessment of Reduction in Mortality), GISSI-HF (Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico-Heart Failure), MAGGIC (Meta-analysis Global Group in Chronic Heart Failure), and SHFM (Seattle Heart Failure Model). Patients with hospitalized HF (n = 6,920) and ambulatory HF patients missing any variable needed to estimate each score (n = 3,267) were excluded, leaving a final sample of 6,161 patients. Results: At 1-year follow-up, 5,653 of 6,161 patients (91.8%) were alive. The observed-to-predicted survival ratios (CHARM: 1.10, GISSI-HF: 1.08, MAGGIC: 1.03, and SHFM: 0.98) suggested some overestimation of mortality by all scores except the SHFM. Overprediction occurred steadily across levels of risk using both the CHARM and the GISSI-HF, whereas the SHFM underpredicted mortality in all risk groups except the highest. The MAGGIC showed the best overall accuracy (area under the curve [AUC] = 0.743), similar to the GISSI-HF (AUC = 0.739; p = 0.419) but better than the CHARM (AUC = 0.729; p = 0.068) and particularly better than the SHFM (AUC = 0.714; p = 0.018). Less than 1% of patients received a prognostic estimate from their enrolling physician. Conclusions: Performance of prognostic risk scores is still limited and physicians are reluctant to use them in daily practice. The need for contemporary, more precise prognostic tools should be considered.

AB - Objectives: This study compared the performance of major heart failure (HF) risk models in predicting mortality and examined their utilization using data from a contemporary multinational registry. Background: Several prognostic risk scores have been developed for ambulatory HF patients, but their precision is still inadequate and their use limited. Methods: This registry enrolled patients with HF seen in participating European centers between May 2011 and April 2013. The following scores designed to estimate 1- to 2-year all-cause mortality were calculated in each participant: CHARM (Candesartan in Heart Failure-Assessment of Reduction in Mortality), GISSI-HF (Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico-Heart Failure), MAGGIC (Meta-analysis Global Group in Chronic Heart Failure), and SHFM (Seattle Heart Failure Model). Patients with hospitalized HF (n = 6,920) and ambulatory HF patients missing any variable needed to estimate each score (n = 3,267) were excluded, leaving a final sample of 6,161 patients. Results: At 1-year follow-up, 5,653 of 6,161 patients (91.8%) were alive. The observed-to-predicted survival ratios (CHARM: 1.10, GISSI-HF: 1.08, MAGGIC: 1.03, and SHFM: 0.98) suggested some overestimation of mortality by all scores except the SHFM. Overprediction occurred steadily across levels of risk using both the CHARM and the GISSI-HF, whereas the SHFM underpredicted mortality in all risk groups except the highest. The MAGGIC showed the best overall accuracy (area under the curve [AUC] = 0.743), similar to the GISSI-HF (AUC = 0.739; p = 0.419) but better than the CHARM (AUC = 0.729; p = 0.068) and particularly better than the SHFM (AUC = 0.714; p = 0.018). Less than 1% of patients received a prognostic estimate from their enrolling physician. Conclusions: Performance of prognostic risk scores is still limited and physicians are reluctant to use them in daily practice. The need for contemporary, more precise prognostic tools should be considered.

KW - heart failure

KW - mortality

KW - prognosis

KW - risk score

UR - http://www.scopus.com/inward/record.url?scp=85047058709&partnerID=8YFLogxK

U2 - 10.1016/j.jchf.2018.02.001

DO - 10.1016/j.jchf.2018.02.001

M3 - Article

VL - 6

SP - 452

EP - 462

JO - JACC: Heart Failure

JF - JACC: Heart Failure

SN - 2213-1779

IS - 6

ER -