Abstract
Stopping or preventing structural progression is a goal common to all inflammatory rheumatic diseases. Imaging may capture structural progression across diseases, but is susceptible to measurement error. Progression can be analysed as a continuous change score over time (eg, mean change of the van der Heijde-modified Sharp score) or as a binary change score (eg, percentage of progressors according to the modified New York criteria). Here, we argue that the former takes measurement error into account while the latter ignores it, which may lead to spurious conclusions. We will argue that assumptions underlying commonly used binary definitions of progression are false and we propose a method that incorporates (inevitable) measurement error.
| Original language | English |
|---|---|
| Article number | e000848 |
| Journal | RMD Open |
| Volume | 5 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Feb 2019 |
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Keywords
- axial spondyloarthritis
- imaging
- Rheumatoid Arthritis
- statistics
Cite this
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Percentage of progressors in imaging : Can we ignore regressors? / Sepriano, Alexandre; Ramiro, Sofia; Landewé, Robert; Dougados, Maxime; Van Der Heijde, Desirée.
In: RMD Open, Vol. 5, No. 1, e000848, 01.02.2019.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Percentage of progressors in imaging
T2 - Can we ignore regressors?
AU - Sepriano, Alexandre
AU - Ramiro, Sofia
AU - Landewé, Robert
AU - Dougados, Maxime
AU - Van Der Heijde, Desirée
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Stopping or preventing structural progression is a goal common to all inflammatory rheumatic diseases. Imaging may capture structural progression across diseases, but is susceptible to measurement error. Progression can be analysed as a continuous change score over time (eg, mean change of the van der Heijde-modified Sharp score) or as a binary change score (eg, percentage of progressors according to the modified New York criteria). Here, we argue that the former takes measurement error into account while the latter ignores it, which may lead to spurious conclusions. We will argue that assumptions underlying commonly used binary definitions of progression are false and we propose a method that incorporates (inevitable) measurement error.
AB - Stopping or preventing structural progression is a goal common to all inflammatory rheumatic diseases. Imaging may capture structural progression across diseases, but is susceptible to measurement error. Progression can be analysed as a continuous change score over time (eg, mean change of the van der Heijde-modified Sharp score) or as a binary change score (eg, percentage of progressors according to the modified New York criteria). Here, we argue that the former takes measurement error into account while the latter ignores it, which may lead to spurious conclusions. We will argue that assumptions underlying commonly used binary definitions of progression are false and we propose a method that incorporates (inevitable) measurement error.
KW - axial spondyloarthritis
KW - imaging
KW - Rheumatoid Arthritis
KW - statistics
UR - http://www.scopus.com/inward/record.url?scp=85062210833&partnerID=8YFLogxK
U2 - 10.1136/rmdopen-2018-000848
DO - 10.1136/rmdopen-2018-000848
M3 - Review article
VL - 5
JO - RMD Open
JF - RMD Open
SN - 2044-6055
IS - 1
M1 - e000848
ER -