@article{884af073f12a45509e6f8b8ea79a0eb8,
title = "PEG-Supported Hypervalent Iodine Reagent for Sulfonamide Synthesis",
abstract = "A reusable and recoverable PEG-supported hypervalent iodine reagent is reported. This hypervalent iodine reagent, immobilized in a soluble polymer support, was easily prepared in six steps from PEG-OH 2000. This reagent was successfully applied in a mild sulfonamide synthesis using a sulfinate salt and an amine in up to 95% yield. The use of the soluble polymer allowed a facile workup procedure and reaction monitoring, by simple precipitation and filtration of the reagent, with an easy recovery and subsequent re-oxidation and reuse. This approach greatly improves the sustainability of this sulfonamide synthesis method, avoiding frequent preparation of reagents and generation of waste during the purification steps.",
keywords = "hypervalent iodine, PEG, soluble polymer support, sulfonamide synthesis, sustainable synthesis",
author = "Jo{\~a}o Macara and Poeira, {Diogo L.} and Coelho, {Jaime A.S.} and Marques, {M. Manuel B.}",
note = "Funding Information: info:eu-repo/grantAgreement/FCT/OE/PD%2FBD%2F142864%2F2018/PT# info:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F116322%2F2016/PT# info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT# info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT# info:eu-repo/grantAgreement/FCT/9444 - RNIIIE/PINFRA%2F22161%2F2016/PT# info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FDTP%2F04138%2F2019/PT# JASC thanks the Funda{\c c}{\~a}o para a Ci{\^e}ncia e a Tecnologia (FCT) for Scientific Employment Stimulus 2020/02383/CEECIND. We also thank the Analytic Services of Instituto de Tecnologia Qu{\'i}mica e Biol{\'o}gica Ant{\'o}nio Xavier, ITQB NOVA, for mass spectrometry analysis. Publisher Copyright: {\textcopyright} 2021 BMJ Publishing Group. All rights reserved.",
year = "2021",
month = oct,
day = "21",
doi = "10.1055/s-0040-1719828",
language = "English",
volume = "32",
pages = "1730--1734",
journal = "Synlett",
issn = "0936-5214",
publisher = "Georg Thieme Verlag",
number = "17",
}