PEG-Supported Hypervalent Iodine Reagent for Sulfonamide Synthesis

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2 Citations (Scopus)


A reusable and recoverable PEG-supported hypervalent iodine reagent is reported. This hypervalent iodine reagent, immobilized in a soluble polymer support, was easily prepared in six steps from PEG-OH 2000. This reagent was successfully applied in a mild sulfonamide synthesis using a sulfinate salt and an amine in up to 95% yield. The use of the soluble polymer allowed a facile workup procedure and reaction monitoring, by simple precipitation and filtration of the reagent, with an easy recovery and subsequent re-oxidation and reuse. This approach greatly improves the sustainability of this sulfonamide synthesis method, avoiding frequent preparation of reagents and generation of waste during the purification steps.

Original languageEnglish
Pages (from-to)1730-1734
Number of pages5
Issue number17
Publication statusPublished - 21 Oct 2021


  • hypervalent iodine
  • PEG
  • soluble polymer support
  • sulfonamide synthesis
  • sustainable synthesis


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