Pd-Catalyzed Functionalization of Aryl Amines on a Soluble Polymer Support

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1 Citation (Scopus)


Herein we report the use of a soluble polymer support PEG-2000 on Pd-catalyzed reactions to improve the functionalization of aromatic amines and the synthesis of N-heterocycles. Compatibility of metal-catalyzed reactions for assembling privileged structures such as functionalized anilines were studied. PEG-supported anilines were found to be suitable substrates for Pd-catalyzed N-arylation, Sonogashira and Heck reactions. PEGylated substrates were prepared in yields up to 94%. This work consists on a proof of concept on the use of PEGylated anilines on Pd-catalyzed cross-coupling reactions. Indole core was attained in 82% and 62% yields, via two different routes.

Original languageEnglish
Pages (from-to)2027-2034
Number of pages8
Issue number20
Publication statusPublished - 17 Dec 2020


  • anilines
  • aryl amine
  • functionalization
  • metal-catalyzed
  • PEG


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