Pd-catalysed amination on a soluble polymer support: arylation of anilines with PEG-supported aryl halides

Luísa da Conceição Costa Raínho de Carvalho; Marina J. Dias Pires; Eduarda Fernandes; Mónica Manuel B. Marques

doi:10.1039/c3ra45177a

Pd-catalysed amination on a soluble polymer support: arylation of anilines with PEG-supported aryl halides

Luísa da Conceição Costa Raínho de Carvalho, Marina J. Dias Pires, Eduarda Fernandes, Mónica Manuel B. Marques

Research output: Contribution to journal › Article

6 Citations (Scopus)

Abstract

PEG supported aryl halides were found to serve as substrates for the Pd-catalysed N-arylation of several substituted anilines and alkyl amines under solventless conditions. Moreover, the Pd2dba3/XPhos catalyst system enabled the coupling reactions to take place smoothly with excellent yields under a low catalyst loading (1 mol% Pd and 3 mol% ligand). © 2013 The Royal Society of Chemistry.

Original language	English
Pages (from-to)	25711-25715
Journal	RSC Advances
Volume	3
Issue number	48
DOIs	https://doi.org/10.1039/c3ra45177a
Publication status	Published - 28 Dec 2013

Keywords

SOLID-PHASE SYNTHESIS
POLY(ETHYLENE GLYCOL)
POLYETHYLENE-GLYCOL
BENZIMIDAZOLES
SOLVENT
SYSTEM
AMINES
MEDIA
RESIN
CROSS

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Carvalho, L. D. C. C. R. D., Dias Pires, M. J., Fernandes, E., & Marques, M. M. B. (2013). Pd-catalysed amination on a soluble polymer support: arylation of anilines with PEG-supported aryl halides. RSC Advances, 3(48), 25711-25715. https://doi.org/10.1039/c3ra45177a

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title = "Pd-catalysed amination on a soluble polymer support: arylation of anilines with PEG-supported aryl halides",

abstract = "PEG supported aryl halides were found to serve as substrates for the Pd-catalysed N-arylation of several substituted anilines and alkyl amines under solventless conditions. Moreover, the Pd2dba3/XPhos catalyst system enabled the coupling reactions to take place smoothly with excellent yields under a low catalyst loading (1 mol{\%} Pd and 3 mol{\%} ligand). {\circledC} 2013 The Royal Society of Chemistry.",

keywords = "SOLID-PHASE SYNTHESIS, POLY(ETHYLENE GLYCOL), POLYETHYLENE-GLYCOL, BENZIMIDAZOLES, SOLVENT, SYSTEM, AMINES, MEDIA, RESIN, CROSS",

author = "Carvalho, {Lu{\'i}sa da Concei{\cc}{\~a}o Costa Ra{\'i}nho de} and {Dias Pires}, {Marina J.} and Eduarda Fernandes and Marques, {M{\'o}nica Manuel B.}",

note = "The authors would like to thank Fundacao para a Ciencia e Tecnologia for PhD fellowships to Luisa C. R. Carvalho (SFRH/BD/63407/2009) and to Marina J. Dias Pires (SFRH/BD/89518/2012).",

year = "2013",

month = "12",

day = "28",

doi = "10.1039/c3ra45177a",

language = "English",

volume = "3",

pages = "25711--25715",

journal = "Rsc Advances",

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publisher = "Royal Society of Chemistry",

number = "48",

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TY - JOUR

T1 - Pd-catalysed amination on a soluble polymer support: arylation of anilines with PEG-supported aryl halides

AU - Carvalho, Luísa da Conceição Costa Raínho de

AU - Dias Pires, Marina J.

AU - Fernandes, Eduarda

AU - Marques, Mónica Manuel B.

N1 - The authors would like to thank Fundacao para a Ciencia e Tecnologia for PhD fellowships to Luisa C. R. Carvalho (SFRH/BD/63407/2009) and to Marina J. Dias Pires (SFRH/BD/89518/2012).

PY - 2013/12/28

Y1 - 2013/12/28

N2 - PEG supported aryl halides were found to serve as substrates for the Pd-catalysed N-arylation of several substituted anilines and alkyl amines under solventless conditions. Moreover, the Pd2dba3/XPhos catalyst system enabled the coupling reactions to take place smoothly with excellent yields under a low catalyst loading (1 mol% Pd and 3 mol% ligand). © 2013 The Royal Society of Chemistry.

AB - PEG supported aryl halides were found to serve as substrates for the Pd-catalysed N-arylation of several substituted anilines and alkyl amines under solventless conditions. Moreover, the Pd2dba3/XPhos catalyst system enabled the coupling reactions to take place smoothly with excellent yields under a low catalyst loading (1 mol% Pd and 3 mol% ligand). © 2013 The Royal Society of Chemistry.

KW - SOLID-PHASE SYNTHESIS

KW - POLY(ETHYLENE GLYCOL)

KW - POLYETHYLENE-GLYCOL

KW - BENZIMIDAZOLES

KW - SOLVENT

KW - SYSTEM

KW - AMINES

KW - MEDIA

KW - RESIN

KW - CROSS

U2 - 10.1039/c3ra45177a

DO - 10.1039/c3ra45177a

M3 - Article

VL - 3

SP - 25711

EP - 25715

JO - Rsc Advances

JF - Rsc Advances

SN - 2046-2069

IS - 48

ER -