PEG supported aryl halides were found to serve as substrates for the Pd-catalysed N-arylation of several substituted anilines and alkyl amines under solventless conditions. Moreover, the Pd2dba3/XPhos catalyst system enabled the coupling reactions to take place smoothly with excellent yields under a low catalyst loading (1 mol% Pd and 3 mol% ligand). © 2013 The Royal Society of Chemistry.
- SOLID-PHASE SYNTHESIS
- POLY(ETHYLENE GLYCOL)
Carvalho, L. D. C. C. R. D., Dias Pires, M. J., Fernandes, E., & Marques, M. M. B. (2013). Pd-catalysed amination on a soluble polymer support: arylation of anilines with PEG-supported aryl halides. RSC Advances, 3(48), 25711-25715. https://doi.org/10.1039/c3ra45177a