PEG supported aryl halides were found to serve as substrates for the Pd-catalysed N-arylation of several substituted anilines and alkyl amines under solventless conditions. Moreover, the Pd2dba3/XPhos catalyst system enabled the coupling reactions to take place smoothly with excellent yields under a low catalyst loading (1 mol% Pd and 3 mol% ligand). © 2013 The Royal Society of Chemistry.
- SOLID-PHASE SYNTHESIS
- POLY(ETHYLENE GLYCOL)