Patterns of transmitted HIV drug resistance in Europe vary by risk group

Dineke Frentz; David Van De Vijver; Ana Abecasis; Jan Albert; Osamah Hamouda; Louise Jørgensen; Claudia Kücherer; Daniel Struck; Jean Claude Schmit; Jurgen Vercauteren; Birgitta Åsjö; Claudia Balotta; Colm Bergin; Danail Beshkov; Ricardo Camacho; Bonaventura Clotet; Algirdas Griskevicius; Zehava Grossman; Andrzej Horban; Tatjana Kolupajeva; Klaus Korn; Leondios Kostrikis; Kirsi Liitsola Marek Linka; Claus Nielsen; Dan Otelea; Dimitrios Paraskevis; Roger Paredes; Mario Poljak; Elisabeth Puchhammer-Stöckl; Anders Sönnerborg; Danica Stanekova; Maja Stanojevic; Anne Mieke Vandamme; Charles Boucher; Annemarie Wensing

doi:10.1371/journal.pone.0094495

Patterns of transmitted HIV drug resistance in Europe vary by risk group

Dineke Frentz, David Van De Vijver, Ana Abecasis, Jan Albert, Osamah Hamouda, Louise Jørgensen, Claudia Kücherer, Daniel Struck, Jean Claude Schmit, Jurgen Vercauteren, Birgitta Åsjö, Claudia Balotta, Colm Bergin, Danail Beshkov, Ricardo Camacho, Bonaventura Clotet, Algirdas Griskevicius, Zehava Grossman, Andrzej Horban, Tatjana KolupajevaKlaus Korn, Leondios Kostrikis, Kirsi Liitsola Marek Linka, Claus Nielsen, Dan Otelea, Dimitrios Paraskevis, Roger Paredes, Mario Poljak, Elisabeth Puchhammer-Stöckl, Anders Sönnerborg, Danica Stanekova, Maja Stanojevic, Anne Mieke Vandamme, Charles Boucher, Annemarie Wensing

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30 Citations (Scopus)

Abstract

Background: In Europe, a continuous programme (SPREAD) has been in place for ten years to study transmission of drug resistant HIV. We analysed time trends of transmitted drug resistance mutations (TDRM) in relation to the risk behaviour reported. Methods: HIV-1 patients newly diagnosed in 27 countries from 2002 through 2007 were included. Inclusion was representative for risk group and geographical distribution in the participating countries in Europe. Trends over time were calculated by logistic regression. Results: From the 4317 patients included, the majority was men-having-sex-with-men -MSM (2084, 48%), followed by heterosexuals (1501, 35%) and injection drug users (IDU) (355, 8%). MSM were more often from Western Europe origin, infected with subtype B virus, and recently infected (

Original language	English
Article number	e94495
Journal	PlosOne
Volume	9
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0094495
Publication status	Published - 10 Apr 2014

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Frentz, D., Van De Vijver, D., Abecasis, A., Albert, J., Hamouda, O., Jørgensen, L., Kücherer, C., Struck, D., Schmit, J. C., Vercauteren, J., Åsjö, B., Balotta, C., Bergin, C., Beshkov, D., Camacho, R., Clotet, B., Griskevicius, A., Grossman, Z., Horban, A., ... Wensing, A. (2014). Patterns of transmitted HIV drug resistance in Europe vary by risk group. PlosOne, 9(4), [e94495]. https://doi.org/10.1371/journal.pone.0094495

Frentz, Dineke ; Van De Vijver, David ; Abecasis, Ana ; Albert, Jan ; Hamouda, Osamah ; Jørgensen, Louise ; Kücherer, Claudia ; Struck, Daniel ; Schmit, Jean Claude ; Vercauteren, Jurgen ; Åsjö, Birgitta ; Balotta, Claudia ; Bergin, Colm ; Beshkov, Danail ; Camacho, Ricardo ; Clotet, Bonaventura ; Griskevicius, Algirdas ; Grossman, Zehava ; Horban, Andrzej ; Kolupajeva, Tatjana ; Korn, Klaus ; Kostrikis, Leondios ; Linka, Kirsi Liitsola Marek ; Nielsen, Claus ; Otelea, Dan ; Paraskevis, Dimitrios ; Paredes, Roger ; Poljak, Mario ; Puchhammer-Stöckl, Elisabeth ; Sönnerborg, Anders ; Stanekova, Danica ; Stanojevic, Maja ; Vandamme, Anne Mieke ; Boucher, Charles ; Wensing, Annemarie. / Patterns of transmitted HIV drug resistance in Europe vary by risk group. In: PlosOne. 2014 ; Vol. 9, No. 4.

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abstract = "Background: In Europe, a continuous programme (SPREAD) has been in place for ten years to study transmission of drug resistant HIV. We analysed time trends of transmitted drug resistance mutations (TDRM) in relation to the risk behaviour reported. Methods: HIV-1 patients newly diagnosed in 27 countries from 2002 through 2007 were included. Inclusion was representative for risk group and geographical distribution in the participating countries in Europe. Trends over time were calculated by logistic regression. Results: From the 4317 patients included, the majority was men-having-sex-with-men -MSM (2084, 48%), followed by heterosexuals (1501, 35%) and injection drug users (IDU) (355, 8%). MSM were more often from Western Europe origin, infected with subtype B virus, and recently infected (",

author = "Dineke Frentz and {Van De Vijver}, David and Ana Abecasis and Jan Albert and Osamah Hamouda and Louise J{\o}rgensen and Claudia K{\"u}cherer and Daniel Struck and Schmit, {Jean Claude} and Jurgen Vercauteren and Birgitta {\AA}sj{\"o} and Claudia Balotta and Colm Bergin and Danail Beshkov and Ricardo Camacho and Bonaventura Clotet and Algirdas Griskevicius and Zehava Grossman and Andrzej Horban and Tatjana Kolupajeva and Klaus Korn and Leondios Kostrikis and Linka, {Kirsi Liitsola Marek} and Claus Nielsen and Dan Otelea and Dimitrios Paraskevis and Roger Paredes and Mario Poljak and Elisabeth Puchhammer-St{\"o}ckl and Anders S{\"o}nnerborg and Danica Stanekova and Maja Stanojevic and Vandamme, {Anne Mieke} and Charles Boucher and Annemarie Wensing",

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Frentz, D, Van De Vijver, D, Abecasis, A, Albert, J, Hamouda, O, Jørgensen, L, Kücherer, C, Struck, D, Schmit, JC, Vercauteren, J, Åsjö, B, Balotta, C, Bergin, C, Beshkov, D, Camacho, R, Clotet, B, Griskevicius, A, Grossman, Z, Horban, A, Kolupajeva, T, Korn, K, Kostrikis, L, Linka, KLM, Nielsen, C, Otelea, D, Paraskevis, D, Paredes, R, Poljak, M, Puchhammer-Stöckl, E, Sönnerborg, A, Stanekova, D, Stanojevic, M, Vandamme, AM, Boucher, C & Wensing, A 2014, 'Patterns of transmitted HIV drug resistance in Europe vary by risk group', PlosOne, vol. 9, no. 4, e94495. https://doi.org/10.1371/journal.pone.0094495

Patterns of transmitted HIV drug resistance in Europe vary by risk group. / Frentz, Dineke; Van De Vijver, David; Abecasis, Ana; Albert, Jan; Hamouda, Osamah; Jørgensen, Louise; Kücherer, Claudia; Struck, Daniel; Schmit, Jean Claude; Vercauteren, Jurgen; Åsjö, Birgitta; Balotta, Claudia; Bergin, Colm; Beshkov, Danail; Camacho, Ricardo; Clotet, Bonaventura; Griskevicius, Algirdas; Grossman, Zehava; Horban, Andrzej; Kolupajeva, Tatjana; Korn, Klaus; Kostrikis, Leondios; Linka, Kirsi Liitsola Marek; Nielsen, Claus; Otelea, Dan; Paraskevis, Dimitrios; Paredes, Roger; Poljak, Mario; Puchhammer-Stöckl, Elisabeth; Sönnerborg, Anders; Stanekova, Danica; Stanojevic, Maja; Vandamme, Anne Mieke; Boucher, Charles; Wensing, Annemarie.

In: PlosOne, Vol. 9, No. 4, e94495, 10.04.2014.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Patterns of transmitted HIV drug resistance in Europe vary by risk group

AU - Frentz, Dineke

AU - Van De Vijver, David

AU - Abecasis, Ana

AU - Albert, Jan

AU - Hamouda, Osamah

AU - Jørgensen, Louise

AU - Kücherer, Claudia

AU - Struck, Daniel

AU - Schmit, Jean Claude

AU - Vercauteren, Jurgen

AU - Åsjö, Birgitta

AU - Balotta, Claudia

AU - Bergin, Colm

AU - Beshkov, Danail

AU - Camacho, Ricardo

AU - Clotet, Bonaventura

AU - Griskevicius, Algirdas

AU - Grossman, Zehava

AU - Horban, Andrzej

AU - Kolupajeva, Tatjana

AU - Korn, Klaus

AU - Kostrikis, Leondios

AU - Linka, Kirsi Liitsola Marek

AU - Nielsen, Claus

AU - Otelea, Dan

AU - Paraskevis, Dimitrios

AU - Paredes, Roger

AU - Poljak, Mario

AU - Puchhammer-Stöckl, Elisabeth

AU - Sönnerborg, Anders

AU - Stanekova, Danica

AU - Stanojevic, Maja

AU - Vandamme, Anne Mieke

AU - Boucher, Charles

AU - Wensing, Annemarie

N1 - PMID:24721998 WOS:000336909100083

PY - 2014/4/10

Y1 - 2014/4/10

N2 - Background: In Europe, a continuous programme (SPREAD) has been in place for ten years to study transmission of drug resistant HIV. We analysed time trends of transmitted drug resistance mutations (TDRM) in relation to the risk behaviour reported. Methods: HIV-1 patients newly diagnosed in 27 countries from 2002 through 2007 were included. Inclusion was representative for risk group and geographical distribution in the participating countries in Europe. Trends over time were calculated by logistic regression. Results: From the 4317 patients included, the majority was men-having-sex-with-men -MSM (2084, 48%), followed by heterosexuals (1501, 35%) and injection drug users (IDU) (355, 8%). MSM were more often from Western Europe origin, infected with subtype B virus, and recently infected (

AB - Background: In Europe, a continuous programme (SPREAD) has been in place for ten years to study transmission of drug resistant HIV. We analysed time trends of transmitted drug resistance mutations (TDRM) in relation to the risk behaviour reported. Methods: HIV-1 patients newly diagnosed in 27 countries from 2002 through 2007 were included. Inclusion was representative for risk group and geographical distribution in the participating countries in Europe. Trends over time were calculated by logistic regression. Results: From the 4317 patients included, the majority was men-having-sex-with-men -MSM (2084, 48%), followed by heterosexuals (1501, 35%) and injection drug users (IDU) (355, 8%). MSM were more often from Western Europe origin, infected with subtype B virus, and recently infected (

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U2 - 10.1371/journal.pone.0094495

DO - 10.1371/journal.pone.0094495

M3 - Article

C2 - 24721998

AN - SCOPUS:84899537490

VL - 9

JO - PlosOne

JF - PlosOne

SN - 1932-6203

IS - 4

M1 - e94495

ER -

Patterns of transmitted HIV drug resistance in Europe vary by risk group

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