Pathologic Risk Factors of Adenocarcinoma of the Gastric Cardia and Gastroesophageal Junction

Fátima Carneiro, Paula Chaves

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Available evidence supports the existence of two major pathways of neoplastic development in the gastroesophageal region: the Barrett pathway, related to GER disease, and the gastric pathway, related to H pylori infection. The existence of an independent junctional pathway is questionable, and GEJ adenocarcinomas share features of esophageal and gastric adenocarcinomas. So far it has been impossible to accommodate in a single, coherent classification, all data that are provided by different levels and tools of observation in tumors that develop in the gastroesophageal region. That is why the stratification of pathologic risk factors in such tumors, and their respective precursors, incorporates features from topography, histology, immunohistochemistry, and molecular pathology.

Original languageEnglish
Pages (from-to)697-714
Number of pages18
JournalSurgical Oncology Clinics Of North America
Volume15
Issue number4
DOIs
Publication statusPublished - 1 Oct 2006

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