Pathologic fracture and healthcare resource utilisation: A retrospective study in eight European countries

Jean Jacques Body, Yves Pascal Acklin, Oliver Gunther, Guy Hechmati, João Pereira, Nikos Maniadakis, Evangelos Terpos, Jindrich Finek, Roger von Moos, Susan Talbot, Harm Sleeboom

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Abstract

Background Skeletal-related events (SREs; pathologic fracture [PF], spinal cord compression and radiation or surgery to bone) are common complications of bone metastases or bone lesions and can impose a considerable burden on patients and healthcare systems. In this study, the healthcare resource utilisation (HRU) associated with PFs in patients with bone metastases or lesions secondary to solid tumours or multiple myeloma was estimated in eight European countries. Methods Eligible patients were identified in Austria, the Czech Republic, Finland, Greece, Poland, Portugal, Sweden and Switzerland. HRU data were extracted from hospital charts from 3.5 months before the index PF (defined as a PF preceded by a 6.5-month period without a SRE) until 3 months after the last SRE during the study period. Changes from baseline in the number and duration of inpatient stays, number of outpatient visits and number of procedures provided were recorded. Results Overall, 118 patients with PFs of long bones (those longer than they are wide, e.g. the femur) and 241 patients with PFs of other bones were included. Overall, HRU was greater in patients with long bone PFs than in those with PFs of other bones. A higher proportion of patients with long bone PFs had multiple SREs (79.7%), and more of their SREs were considered to be linked (73.4%) compared with patients with PFs of other bones (51.0% and 47.2%, respectively). Conclusion The increased number and duration of inpatient stays for PFs of long bones compared with those for PFs of other bones may be due in part to the requirement for complicated and lengthy rehabilitation in patients with long bone PFs. Implementing strategies to delay or reduce the number of PFs experienced by patients with bone metastases or lesions may therefore reduce the associated HRU and patient burden.

Original languageEnglish
Pages (from-to)185-193
Number of pages9
JournalJournal of Bone Oncology
Volume5
Issue number4
Publication statusPublished - 1 Nov 2016

Keywords

  • Bone metastases
  • Healthcare resource utilisation
  • Pathologic fracture
  • Skeletal-related event
  • Solid tumour

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    Body, J. J., Acklin, Y. P., Gunther, O., Hechmati, G., Pereira, J., Maniadakis, N., ... Sleeboom, H. (2016). Pathologic fracture and healthcare resource utilisation: A retrospective study in eight European countries. Journal of Bone Oncology, 5(4), 185-193.