Participation of leukotrienes in the immune modulation of oral tolerance

Sandra R P de Oliveira, Auro Nomizo, Fabiani G. Frantz, Lúcia H. Faccioli, Ana Paula Keller de Matos, Emanuel Carrilho, Ana Afonso, Fernanda de Freitas Anibal

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Oral tolerance (OT) is characterized as a peripheral immune tolerance form, in which, mature lymphocytes in lymphoid tissues associated with mucosa, become non-functional or hypo responsive due to prior oral administration of antigen. OT is an important immunological phenomenon due to its therapeutic potential in inflammatory processes and others diseases. Here we evaluated leukotriene role in the induction of OT, as well as, the production of cytokines IL-5 and IFN-γ in leukotriene deficient animals (knock-out). Our results suggested that even in the presence of OT and leukotrienes absence, cytokine IFN-γ remains being secreted, which gives us an indication of immune system specificity and also that IFN-γ participates in various immune processes.

Original languageEnglish
Article number242
Pages (from-to)p. 242-249
Number of pages7
JournalFrontiers in Microbiology
VolumeVol. 8
Issue numbern.º FEB
Publication statusPublished - 21 Feb 2017


  • Cytokines
  • IFN-γ
  • IL-5
  • Immune response
  • Leukotriene
  • Oral tolerance


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