Partial excision of the chromosomal cassette containing the methicillin resistance determinant results in methicillin-susceptible Staphylococcus aureus

Duarte Emanuel Soeiro de Carvalho Oliveira; N.A. Faria; Rockefeller University

doi:10.1128/JCM.43.8.4191-4193.2005

Partial excision of the chromosomal cassette containing the methicillin resistance determinant results in methicillin-susceptible Staphylococcus aureus

Duarte Emanuel Soeiro de Carvalho Oliveira, N.A. Faria, Rockefeller University

Instituto de Tecnologia Química e Biológica António Xavier (ITQB)

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

We report a detailed characterization of methicillin-susceptible Staphylococcus aureus isolates from five French hospitals negative for both the mecA and the ccrAB loci but positive for the IS431::pUB110::IS431::dcs structure, present in some Staphylococcus cassette chromosome mec (SCCmec) types. The presence of SCCmec-associated elements suggests that this unusual resistant phenotype is due to a partial excision of SCCmec from epidemic methicillin-resistant S. aureus. The hypothesis of a genetic relatedness is strengthened by common sequence and spa types and similar susceptibility patterns.

Original language	English
Pages (from-to)	4191-4193
Journal	Journal Of Clinical Microbiology
Volume	43
Issue number	8
DOIs	https://doi.org/10.1128/JCM.43.8.4191-4193.2005
Publication status	Published - 1 Jan 2005

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10.1128/JCM.43.8.4191-4193.2005

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title = "Partial excision of the chromosomal cassette containing the methicillin resistance determinant results in methicillin-susceptible Staphylococcus aureus",

abstract = "We report a detailed characterization of methicillin-susceptible Staphylococcus aureus isolates from five French hospitals negative for both the mecA and the ccrAB loci but positive for the IS431::pUB110::IS431::dcs structure, present in some Staphylococcus cassette chromosome mec (SCCmec) types. The presence of SCCmec-associated elements suggests that this unusual resistant phenotype is due to a partial excision of SCCmec from epidemic methicillin-resistant S. aureus. The hypothesis of a genetic relatedness is strengthened by common sequence and spa types and similar susceptibility patterns.",

keywords = "IDENTIFICATION, COMMUNITY, EMERGENCE, MEC, PANDEMIC CLONES, REGION, VARIANTS, ELEMENT, STRAINS, EVOLUTION",

author = "Oliveira, {Duarte Emanuel Soeiro de Carvalho} and N.A. Faria and Rockefeller University",

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Partial excision of the chromosomal cassette containing the methicillin resistance determinant results in methicillin-susceptible Staphylococcus aureus. / Oliveira, Duarte Emanuel Soeiro de Carvalho ; Faria, N.A.; University, Rockefeller.
In: Journal Of Clinical Microbiology, Vol. 43, No. 8, 01.01.2005, p. 4191-4193.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Partial excision of the chromosomal cassette containing the methicillin resistance determinant results in methicillin-susceptible Staphylococcus aureus

AU - Oliveira, Duarte Emanuel Soeiro de Carvalho

AU - Faria, N.A.

AU - University, Rockefeller

N1 - Oliveira, DC; Faria, NA

PY - 2005/1/1

Y1 - 2005/1/1

N2 - We report a detailed characterization of methicillin-susceptible Staphylococcus aureus isolates from five French hospitals negative for both the mecA and the ccrAB loci but positive for the IS431::pUB110::IS431::dcs structure, present in some Staphylococcus cassette chromosome mec (SCCmec) types. The presence of SCCmec-associated elements suggests that this unusual resistant phenotype is due to a partial excision of SCCmec from epidemic methicillin-resistant S. aureus. The hypothesis of a genetic relatedness is strengthened by common sequence and spa types and similar susceptibility patterns.

AB - We report a detailed characterization of methicillin-susceptible Staphylococcus aureus isolates from five French hospitals negative for both the mecA and the ccrAB loci but positive for the IS431::pUB110::IS431::dcs structure, present in some Staphylococcus cassette chromosome mec (SCCmec) types. The presence of SCCmec-associated elements suggests that this unusual resistant phenotype is due to a partial excision of SCCmec from epidemic methicillin-resistant S. aureus. The hypothesis of a genetic relatedness is strengthened by common sequence and spa types and similar susceptibility patterns.

KW - IDENTIFICATION

KW - COMMUNITY

KW - EMERGENCE

KW - MEC

KW - PANDEMIC CLONES

KW - REGION

KW - VARIANTS

KW - ELEMENT

KW - STRAINS

KW - EVOLUTION

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DO - 10.1128/JCM.43.8.4191-4193.2005

M3 - Article

SN - 0095-1137

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SP - 4191

EP - 4193

JO - Journal Of Clinical Microbiology

JF - Journal Of Clinical Microbiology

IS - 8

ER -

Partial excision of the chromosomal cassette containing the methicillin resistance determinant results in methicillin-susceptible Staphylococcus aureus

Abstract

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